Clinical trials: Mental
Anorexia Nervosa
Study of Psilocybin for Anorexia in Young Adults
This is a single site trial of psilocybin therapy for the treatment of refractory Anorexia Nervosa in young adults. The psilocybin therapy will include three preparatory sessions, psilocybin dosing session one (20mg), two…
- Trial name
- SPANYA (NCT06399263)
- Testing
- Psilocybin, Preparation and Integration Sessions
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Marissa Raymond-Flesch, MD, MPH
Opioid-Induced Bowel Dysfunction, Constipation
The Effect of Naldemedine on Opioid-induced Bowel Dysfunction
Opioid-induced bowel dysfunction is a frequent condition during opioid therapy for chronic pain. Indeed, up to 90% of people on opioid treated patients experience constipation.
- Trial name
- NCT06334198
- Testing
- Naldemedine, Tramadol
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asbjørn Mohr Drewes
Mild Cognitive Impairment
ENHANCING PHYSICAL and COGNITIVE EFFICIENCY in INDIVIDUALS AT RISK of DEMENTIA USING WHOLE-BODY ELECTROMYOSTIMULATION
This study aimed to evaluate the effectiveness of twelve weeks whole-body electrical muscle stimulation combined with aerobic exercises.
- Trial name
- NCT06669598
- Testing
- Whole Body Electromyostimulation, control group
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Molise
Opioid-use Disorder, Overdose of Opiate
Patient Reported Outcomes for Opioid Use Disorder
The goal of the project is to build a clinical data research infrastructure that will begin to enhance capacity to use electronic health record (EHR) data and patient reported outcomes measures (PROs) to conduct opioid related…
- Conditions
- Opioid-use Disorder, Overdose of Opiate, Patient Participation
- Trial name
- NCT03985163
- Testing
- Patient Reported Outcomes Electronic Survey
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder (MDD)
Comparison of Yuxintine With Placebo in Treatment of MDD
The purpose of this study is to determine whether Yuxintine Capsule in different doses are effective in the treatment of Depression.
- Trial name
- NCT02395263
- Testing
- Yuxintine
- Where
- 10 sites in China
- Volunteers
- 160 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Prostate Cancer
Predicting Cognitive Decline From Androgen Deprivation Therapy
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the…
- Trial name
- ABC (NCT05820932)
- Testing
- Blood-based assay, Cognitive assessments, Quality of Life Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Children, Preschool, Pain and Anxiety
Storytelling Caterpillar - Pain, Anxiety, and Satisfaction
This randomized controlled trial aims to evaluate the effect of using the "Storytelling Caterpillar" toy on pain, anxiety, and parental satisfaction during blood draw procedures in children aged 3 to 6 years.
- Trial name
- SC-PAS (NCT07127432)
- Testing
- The Storytelling Caterpillar
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Koç University
General Anxiety Disorder, Social Anxiety Disorder
A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder
This study is being conducted to evaluate the safety and effectiveness of memantine Add-On treatment of patients who are currently taking an SNRI or SSRI and who remain anxious and symptomatic despite treatment.
- Trial name
- NCT00411398
- Testing
- Namenda/Memantine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Multimorbidity, Comorbidity
A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students
Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second…
- Conditions
- Multimorbidity, Comorbidity, Common Diseases in Children and Adolescents, Myopia
- Trial name
- NCT07237698
- Testing
- The intervention group participated in specialized physical education courses.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiaoyan Wu
Panic Disorders
Study Comparing Venlafaxine vs. Paroxetine in Panic Disorder
The purpose of this pilot study is to evaluate the improvement in social function following therapy with venlafaxine extended release (XR) in the treatment of panic disorder (PD) in comparison to paroxetine.
- Trial name
- NCT00195598
- Testing
- VENLAFAXINE, Paroxetine
- Where
- 4 sites in Brazil
- Volunteers
- 70 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Alzheimer Disease, Dementia
Tele-Savvy for Latino Caregivers
Latino caregivers of individuals with Alzheimer's disease and related dementias experience high levels of stress burden and depressive symptoms and are underrepresented in caregiver intervention research.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Stress
- Trial name
- NCT07290387
- Testing
- Tele Savvy for Latino Caregivers
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Rochester
Sleep Disorders, Sciatica
Intravascular Laser and Electroacupuncture for Sciatica With Insomnia: A Pilot Trial
Sciatica is a common condition worldwide, with prevalence rates ranging from 1.2% to 43%. Chronic sciatica is often associated with sleep disturbances, forming a bidirectional loop where persistent nociceptive input disrupts…
- Trial name
- NCT06755593
- Testing
- Electroacupuncture, Intravascular Low-Level Laser Therapy (ILIB)
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Le Hoang Minh Quan
Mental Health Issue, Psychosocial Functioning
MyHEARTSMAP In-Patient Study
Often, mental health (MH) conditions are under-identified in youth with chronic health conditions, which can lead to long-term health consequences and can impact their everyday lives.
- Trial name
- NCT06553521
- Testing
- MyHEARTSMAP Youth Self-assessment Tool (At Admission)
- Where
- Canada
- Volunteers
- 289 people
- Sponsor
- University of British Columbia
Binge-Eating Disorder
Theta Burst Stimulation in Binge Eating Disorder: A Single Session RCT
Binge eating disorder (BED) is a common and disabling eating disorder (ED) which presents a substantial disease burden. Individuals seeking treatment for binge eating difficulties typically receive talking therapy treatment…
- Trial name
- BITE (NCT04130906)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- United Kingdom
- Sponsor
- King's College London
Anxiety Disorders, Depression
Project COPE (Coping Options for Parent Empowerment)
The purpose of this research study is to collect information to better understand caregiver responses to COVID-19 stress and to help caregivers of children with Autism Spectrum Disorder (ASD) cope with these stressors.
- Trial name
- NCT04715906
- Testing
- UP-Caregiver
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Dementia With Lewy Bodies
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies
This study will be conducted to compare Irsenontrine to placebo on the cognitive endpoint of Montreal Cognitive Assessment (MoCA) and the global clinical endpoint of Clinician's Interview Based Impression of Change Plus…
- Trial name
- NCT03467152
- Testing
- Irsenontrine
- Where
- 74 sites in United States, France and 5 more
- Volunteers
- 326 people
- Sponsor
- Eisai Inc.
Schizophrenia, Major Depressive Disorder
DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole
This is a 12 month, pragmatic trial designed to assess the differences in a digital medicine system (DMS)- ABILIFY MYCITE (Aripiprazole tablets with sensor)- measuring adherence versus treatment as usual (TAU) for adult patients…
- Conditions
- Schizophrenia, Major Depressive Disorder, Bi-Polar Disorder, Schizo Affective Disorder
- Trial name
- DIMES (NCT03881449)
- Testing
- ABILIFY MYCITE
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Durham VA Medical Center
Depression, Dementia
Home-delivered Intervention for Depressed, Cognitively Impaired Elders
Among older adults the combination of depression, cognitive impairment (memory problems), and disability contribute to a worsening of physical and mental health and to poor treatment outcomes.
- Conditions
- Depression, Dementia, Geriatrics
- Trial name
- NCT01350349
- Testing
- Problem Adaptation Therapy (PATH), Supportive Therapy
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Weill Medical College of Cornell University
Substance Abuse
Accuracy & Usability Study for Soberlink Cellular Device
This study scope is to validate the accuracy and usability of the Soberlink Cellular Device in comparison to a predicate device, BACtrack S80 Pro.
- Trial name
- NCT02794038
- Testing
- Soberlink Cellular Device, BACtrack S80 Pro
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Soberlink Healthcare LLC
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