Clinical trials: Mental Deterioration
Epilepsy, Cognitive Decline
Influence of Non-invasive Neurostimulation (Transcutaneous Vagus Nerve Stimulation) on 1. the Noradrenergic Release in the Brain and 2. a Neuropsychological Memory Task
The goal of this study is to investigate the influence of transcutaneous vagus nerve stimulation 1. on the noradrenergic system in the brain and 2. on memory, in healthy volunteers.
- Trial name
- NCT02409069
- Testing
- Transcutaneous vagus nerve stimulation (Nemos®, Cerbomed GmbH)
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Alzheimer Disease, Dementia
BarcelonaBeta Dementia Prevention Research Clinic: a Study on Risk Factors Disclosure
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03847038
- Testing
- Preventive strategies advice and dementia risk estimate disclosure
- Where
- Spain
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Subjective Cognitive Decline
Cholinergic Mechanisms of Attention in Aging
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by…
- Trial name
- NCT04756232
- Testing
- Mecamylamine Challenge
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Physical Activity, Age-related Cognitive Decline
The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions
The proposed study is intended to examine the connection between two types of inhibition - cognitive and motor and the connection between motor inhibitory functions and a single bout of physical exercise in the context of age and…
- Trial name
- NCT03750812
- Testing
- Aerobic Exercise, Watching television
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Cognitive Decline
Multicomponent Program for Addressing Cognition in Rural Communities
The study is designed to develop and evaluate a multicomponent intervention program among older rural-residing and African American residents with a long-term goal of reducing risk factors for Alzheimer's disease.
- Trial name
- MPAAC-R (NCT07018830)
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cognition, Obesity
Nutrition for Brain and Body Health (BB-Health) Feasibility Trial
The goal of the trial is to determine the feasibility of implementing a specific nutrition regimen used alone or in combination with a behavioral weight loss (WL) intervention on cognition and cerebral blood flow in older adults…
- Trial name
- BB-Health (NCT05542199)
- Testing
- Multicomponent nutrition supplement (MCNS), Behavioral weight loss program
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tufts University
Cognitive Dysfunction
Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation
An observational study to determine outcomes of older adults who are under naturopathic medical care for cognitive complaints at a specific clinic in Southern California.
- Trial name
- ITHNCLR (NCT04284449)
- Testing
- Whole-practice cognitive optimization
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Subjective Cognitive Decline, Alzheimer Dementia
Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
In this study the investigators explore a pragmatic strategy to increase cognitive screening rates in the community. The investigators will compare the monetary value of different combinations of SCD questionnaires, digital…
- Trial name
- NCT06191952
- Testing
- Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Social Isolation in Older Adults, Loneliness
Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health
This study evaluates the effectiveness of a community-based social connection intervention program (SCIP) designed to reduce social isolation and loneliness and improve cardiovascular and brain health among older adults living in…
- Conditions
- Social Isolation in Older Adults, Loneliness, Stroke, Cognitive Decline
- Trial name
- NCT07319663
- Testing
- Social Connection Intervention Program (SCIP): Community activities, peer-support groups, and home-based coaching to reduce social isolation and loneliness.
- Where
- Ecuador
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Mild Cognitive Impairment, Mild Dementia
Assessing Cognitive Decline at Home
Neuropsychiatric symptoms (NPS) refer to a range of mental and emotional issues that can be observed through how patients move, perform daily tasks, and express feelings on their faces.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia
- Trial name
- NCT06704971
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Frail Elderly Syndrome, Cognitive Impairment
Taiwan Health Promotion Intervention Study for Elders
Objectives: 1-year multidomain health promotion on prevention of physical and cognitive decline for community-living older people.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Cognitive Decline
- Trial name
- THISCE (NCT03056768)
- Testing
- Multidomain intervention, Active control
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Aging, Age Problem
Impact of Comprehensive Dietary Counseling on Dietary Quality, Mental Health, and Quality of Life in Older Adults
As a person ages, an incidence of mental distress such as depression and anxiety increases while the quality of life decreases. Singapore's population is aging rapidly and older adults may suffer from mental distress and…
- Conditions
- Aging, Age Problem, Age-related Cognitive Decline, Age-Related Atrophy
- Trial name
- NCT03702335
- Testing
- Dietary Counselling
- Where
- 2 sites in Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Enhancement, Subjective Cognitive Decline (SCD)
The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older…
- Conditions
- Cognitive Enhancement, Subjective Cognitive Decline (SCD), Mild Cognitive Impairmen
- Trial name
- NCT07895979
- Testing
- Daily Life VR Training, Non-Conditional Game VR Training, Traditional Cognitive Training
- Where
- Taiwan
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aging, Memory Impairment
Neurocognitive Study for the Aging-a Longitudinal Study With a Greek Cypriot Cohort
The Neurocognitive Study for the Aging (NEUROAGE) was initially funded by the Cyprus Innovation Foundation and has received subsequent funding by the European Union Regional Development Fund.
- Conditions
- Aging, Memory Impairment, Cognitive Decline, Mild Cognitive Disorder
- Trial name
- NEUROAGE (NCT01481246)
- Testing
- Categorization training, Psychosocial and Psychoeducational Group training
- Where
- Cyprus
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Healthy
Behavioral and Physiological Effects of Visual Training
The primary objective of this study is to evaluate the learnability of a 3 week, 40 minutes per day, 5 day per week, computer-based visual training exercise by healthy mature individuals undergoing normal aging.
- Trial name
- NCT00526942
- Testing
- SAAGE-designed, visual memory-based cognitive training
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Alzheimer Disease
U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk
The purpose of this research study is to see if lifestyle changes can protect memory and thinking (cognition) as we age. A recent study in Finland found that a combination of physical and cognitive exercise, diet, and social…
- Trial name
- POINTER (NCT03688126)
- Testing
- Self-Guided Lifestyle Intervention, Structured Lifestyle Intervention
- Where
- 6 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cognitive Decline
Effects of Multidomain Intervention on Cognitive Function in Community-dwelling Elderly
The aging population has contributed to an increase in cognitive decline. To mitigate the rise in the dementia population, it is crucial to prevent cognitive decline in older adults with normal functioning, subjective cognitive…
- Trial name
- NCT06180161
- Testing
- multidomain intervention
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital