Clinical trials: Mental Deterioration
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton
Cognitive Decline, Life Style
Dutch Multidomain Lifestyle Intervention in Older Adults at Risk of Cognitive Decline
FINGER-NL is a multi-center, randomized, controlled, multidomain lifestyle intervention trial among 1,206 older adults at risk for cognitive decline with a duration of 24 months.
- Conditions
- Cognitive Decline, Life Style, Risk Reduction
- Trial name
- FINGER-NL (NCT05256199)
- Testing
- Multidomain lifestyle intervention
- Where
- 5 sites in Netherlands
- Volunteers
- 1,210 people, healthy volunteers welcome
- Sponsor
- Alzheimercentrum Amsterdam
Aging
Activities for Cognitive Enhancement of Seniors
Cognitive aging and cognitive decline are important public health concerns in an aging US population. The investigators will conduct a randomized controlled trail among healthy older adults to assess effects of several innovative…
- Trial name
- ACE-Seniors (NCT01094509)
- Testing
- Tai Chi, Guided autobiography, Qigong
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Age-related Cognitive Decline
Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function
The aim of the current study is to investigate whether acute and 12-weeks daily intake of Nordic berries can improve cognitive abilities of adults without cognitive disease, and whether the effect can be linked to changes in…
- Trial name
- SCANBerry (NCT05693441)
- Testing
- Active berry product, Reference berry-like product
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Cognitive Decline, Healthy Aging
Non-invasive Brain Stimulation and Strategic Memory Training
Physiological aging is often associated with memory function decline. Recently, the use of transcranial direct current stimulation (tDCS), a type of non-invasive brain stimulation, has been combined with adaptive working memory…
- Trial name
- StMe-tDCS (NCT05929872)
- Testing
- Non-invasive brain stimulation
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cognitive Decline, Executive Dysfunction
Fitness on White Matter and Cognition in Aging
Cardiorespiratory fitness (CRF) is associated with decreased risk for mild cognitive impairment (MCI) and dementia. CRF is linked with more conserved gray and white matter (WM) volume, improved WM microstructural integrity, and…
- Conditions
- Cognitive Decline, Executive Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03775941
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Suffolk University
Alzheimer Disease, Cognitive Decline Due to Alzheimer Disease
Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia
Two-year double-masked trial of over-the-counter dosage of naproxen sodium vs placebo in 200 cognitively normal participants with a parental or multiplex first-degree family history Alzheimer's disease (AD) dementia.
- Conditions
- Alzheimer Disease, Cognitive Decline Due to Alzheimer Disease, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- NCT02702817
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Age-related Cognitive Decline
A Group Study on the Effects of a Short Multi-Domain Cognitive Training in Healthy Elderly Italian People
Alongside physiological cognitive ageing, nowadays there is an alarming increase in the incidence of dementia that requires communities to invest in its prevention.
- Trial name
- NCT03771131
- Testing
- Multi-domain cognitive training
- Where
- Italy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alzheimer's Disease，Mild Cognitive Impairment
Cohort Study on Cognitive Decline in Elderly
Alzheimer's Disease (AD) prevention and control currently face severe challenges, with limited treatment options and effectiveness available. Once the disease progresses to the AD stage, it is essentially irreversible.
- Trial name
- NCT07093892
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Deep Brain Stimulation, Parkinson Disease
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with…
- Trial name
- NCT06960096
- Testing
- DBS combined with fMRI
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy
Effects of Dietary Interventions on the Aging Brain
The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00996229
- Testing
- Caloric restriction, Omega-3 (fish oil capsules), Resveratrol
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Aging, Sarcopenia
PANGeA - Physical Activity and Nutrition for Quality Ageing
General objectives of the project Defining healthy ageing factors; Setting up content-related bases of the international excellence centre (SLO-ITA) in the field of health of elderly citizens; Raising awareness on the…
- Conditions
- Aging, Sarcopenia, Cognitive Decline
- Trial name
- PANGeA_MM (NCT04899531)
- Testing
- Longitudinal observation
- Where
- Slovenia
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Cognition Disorders
18F-AV-1451 PET Imaging in Participants Enrolled in the LEARN Study
Approximately 50 participants enrolled in the LEARN study (NCT02488720) will be enrolled in the LEARN-Tau study. The study designed to evaluate the imaging characteristics of 18F-AV-1451 in participants enrolled in the LEARN…
- Trial name
- LEARN-Tau (NCT02850146)
- Testing
- 18F-AV-1451
- Where
- 7 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dementia, Cognitive Assessment
Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community
The investigator's objective is to explore the definitive evidence of mushroom on cognitive functions among at-risk middle-aged and young-olds.
- Trial name
- NCT07775833
- Testing
- Golden oyster mushroom powder
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Decline
Preventing Cognitive Decline with Metformin
A randomised control study of metformin in people with mild cognitive impairment and without diabetes mellitus to determine effects on cognitive decline and neuroimaging over 3 years.
- Trial name
- MetMemory (NCT04511416)
- Testing
- Metformin XR, 500-2000mg nocte
- Where
- Australia
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Subjective Cognitive Decline
REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study
Older adults with subjective cognitive decline (SCD) are at high risk of developing dementia and frequently experience subclinical symptoms (e.g., anxiety, depression) which are themselves associated with dementia and cognitive…
- Trial name
- SCD-ReCODED (NCT06429215)
- Testing
- Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Mild Cognitive Impairment (MCI), Oral Health
To Exam the Efficacy of Oral Health and Mediterranean Diet Interventions in Preventing Cognitive Decline Among Older Adults With Mild Cognitive Impairment
At present, many literatures have confirmed that the Mediterranean diet has the effect of delaying cognitive degeneration in patients with mild cognitive impairment, and can also slow down the speed of brain atrophy.
- Conditions
- Mild Cognitive Impairment (MCI), Oral Health, Mediterranean Diet
- Trial name
- NCT05865340
- Testing
- oral health + MED diet, oral health, MED diet
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan