Clinical trials: Mental Distress
Domestic Violence, Psychological Distress
GBV, Primary Trauma & Trauma Resilience & Understanding Self-help Therapy Utilization in Uganda
The goal of this community-based interventional study was to determine the effectiveness of the 'Trauma Resilience \& Understanding Self-help Therapy' (TRUST) in managing domestic violence \& primary trauma among formerly…
- Conditions
- Domestic Violence, Psychological Distress, Post-Traumatic Stress Disorder, Suicidality
- Trial name
- GBV (NCT06073964)
- Testing
- Trauma Resilience & Understanding Self-help Therapy
- Where
- Uganda
- Volunteers
- 284 people
- Sponsor
- Kampala International University
Cancer
The Modulatory Role of Internet MBCT on Extracellular Vesicles and Distress in Cancer Patients - Study Protocol
Mindfulness-based interventions (MBIs), such as mindfulness-based stress reduction (MBSR), mindfulness-based cognitive therapy (MBCT), mindfulness-based cancer recovery (MBCR), have been showing promising results in different…
- Trial name
- MINDGAP (NCT04727593)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Treatment as Usual
- Where
- Portugal
- Volunteers
- 111 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Psychosocial Problem, Psychological Distress
Evaluating Impacts of CSS for Veterans and Their Families in Ukraine
This cluster-randomized controlled trial (c-RCT) evaluates the effectiveness of a brief, single-session psychosocial workshop, "CETA Short Session" (CSS), for reducing symptoms of distress and functional impairment and increasing…
- Conditions
- Psychosocial Problem, Psychological Distress, Engagement, Patient
- Trial name
- NCT04234815
- Testing
- CETA Short Session (CSS), Psychoeducation and Safety
- Where
- Ukraine
- Volunteers
- 1,193 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Rumination, Worry
Readiness and Progress in Emotion Regulation Therapy
This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing…
- Conditions
- Rumination, Worry, Self-Criticism, Anxiety
- Trial name
- NCT07478393
- Testing
- Emotion Regulation Therapy via Telehealth
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Teachers College, Columbia University
Psychological Distress, Pain
Hypnotic Communication in Cardiology: A Randomized Controlled Trial
Undergoing medical procedures, especially surgical ones, is a significant source of emotional stress for patients. Emotions like anxiety, fear, anger, and depression often accompany such experiences and can negatively impact…
- Conditions
- Psychological Distress, Pain, Anxiety
- Trial name
- IPNOCARDIO (NCT07424209)
- Testing
- Hypnotic Communication
- Where
- Italy
- Volunteers
- 306 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Post-Traumatic Stress Disorders, Stress Disorders
Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings
The purpose of this study is to evaluate Cognitive-behavioral therapy (CBT) for deployment-related post-traumatic stress disorder (PTSD) that can be used by behavioral health consultants working with Service Members in the…
- Conditions
- Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
- Trial name
- NCT00974402
- Testing
- Cognitive Behavioral Therapy
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Depression, Anxiety
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
The goal is to improve mental health. The study will evaluate the impact of community-based mental health services. Successful completion of this study will contribute to the National Institute of Mental Health Strategic Plan…
- Conditions
- Depression, Anxiety, Psychological Distress, PTSD
- Trial name
- RECOUP-NY (NCT04913766)
- Testing
- Problem Management Plus, Services as Usual
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- George Washington University
Gastrointestinal Cancer, Depression
Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers
The goal of this open-label clinical trial is to assess the feasibility of Ketamine-assisted psychotherapy (KAP) studies for adults with non-operable GI cancers suffering with existential distress.
- Conditions
- Gastrointestinal Cancer, Depression, Anxiety
- Trial name
- TREK (NCT06001372)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Depression, Psychological Distress
Behavior, Biology and Well-Being Study
The central aim of this pilot study is to compare markers of inflammation and gut microbial diversity with users of the Healthy Minds Program (HMP) app, an intervention designed to promote well-being.
- Trial name
- BeWell (NCT06213701)
- Testing
- Healthy Minds Program, Psychoeducation app
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Wisconsin, Madison
Pregnancy Distress
E-health Intervention in Women With Pregnancy Distress
The study aims to reduce the levels of distress (depression and anxiety) during pregnancy. The study investigates the effectiveness of an eHealth pregnancy distress-reducing mindfulness training in women with pregnancy distress.
- Trial name
- NCT03917745
- Testing
- eHealth mindfulness intervention
- Where
- Netherlands
- Volunteers
- 219 people
- Sponsor
- Tilburg University
Fibromyalgia Syndrome
Effect of Soundscapes on Emotional Distress in Fibromyalgia: a 4×4 Crossover Trial
This study tests whether different types of sounds can help reduce emotional distress in people with fibromyalgia. Fibromyalgia is a condition that causes widespread muscle and joint pain and makes people extra sensitive to…
- Trial name
- FMSounDistress (NCT07231289)
- Testing
- Natural soundscape exposure, Urban soundscape exposure, Broadband sound active control
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Universidad de Granada
Relapse Rates Related to Website Usage
Web-based Support for People With Schizophrenia and Their Families
This study will assess the feasibility of using the internet and in-home computers to provide advice from health care professionals, social support, and health information to people with schizophrenia and their families.
- Trial name
- NCT00177983
- Testing
- (relapse rate)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Moral Injury, Distress, Emotional
Digital Interventions for Detection and Reduction of Moral Distress
Stress, anxiety, distress and depression are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Trial name
- VR (NCT05001542)
- Testing
- Educational moral injury video
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Depression, Anxiety, Engagement, Patient
Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design
The overarching goals of this project are to provide the first rigorous test of a scalable and publicly accessible mobile health intervention (IntelliCare) to address emotional distress in women with breast cancer, and to test…
- Trial name
- NCT04583891
- Testing
- IntelliCare, Psychoeducation, Coaching
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- University of Virginia
Group-based, Self-Help Plus (SH+)
Examining the Effect of a Group-Based Stress Management Course on Empowering the Mental Health of Medical Faculty Students and Resident Physicians: A Randomized Controlled Study
Physicians and medical students have higher rates of depression, anxiety, burnout, and suicide risk than the general population, and this disparity often begins early, even during medical school.
- Conditions
- Group-based, Self-Help Plus (SH+), Psychoeducational Intervention, Stress Management Course
- Trial name
- EMPOWER-MD (NCT07679503)
- Testing
- self help plus
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Eskisehir Osmangazi University
Caregiver Distress, Physical Function
Caring for Caregivers With Mind-body Exercise
This pilot study will lay the foundation for the first large-scale trial evaluating the psychosocial and physical health benefits of a widely available and promising Qigong intervention (Eight Brocades) for distressed cancer…
- Conditions
- Caregiver Distress, Physical Function, Quality of Life
- Trial name
- NCT04019301
- Testing
- Baduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Houston
Pelvic Floor Disorder, Loneliness
Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth.
- Conditions
- Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health
- Trial name
- PEARL (NCT07223736)
- Testing
- Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Sexual Dysfunction, Psychological, Relationship Distress
"Walking Together with Love": a Couples-Based Intervention for Sexual and Relationship Distress in Cancer Patients
Cancer diagnosis and treatment often result in significant changes in body appearance, sexual functioning, and relationship quality, leading to distress for both patients and their partners.
- Conditions
- Sexual Dysfunction, Psychological, Relationship Distress, Cancer
- Trial name
- WTL (NCT06906575)
- Testing
- A Comprehensive Intervention to Improve Sexual and Relationship Well-being for Cancer Patients and Their Partners
- Volunteers
- 100 people
- Sponsor
- Yanfei Jin
Well-Being, Psychological, Dissociation
An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers
The proposed study will collect novel data evaluating the feasibility of the NFB training program delivered in an outpatient mental health setting and its influence on mothers' overall sense of well-being, and further investigate…
- Conditions
- Well-Being, Psychological, Dissociation, Maternal Care Patterns, Maternal Behavior
- Trial name
- NCT06054412
- Testing
- Neuroptimal (Zengar, Inc.) Neurofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Relationship Conflict, Relationship Distress
OurRelationship-S: A Digital Relationship-Strengthening Program for Couples Experiencing Substance Misuse
This study tests the effectiveness of an online relationship program that has been tailored for couples in which one or both members are in recovery from substance misuse.
- Trial name
- NCT07159633
- Testing
- Online Couple Intervention
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- OurRelationship