Clinical trials: Metabolic Adaptation
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Diabete Type 2, Diabetic Foot
Prevalence of the Appearance of Diabetic Ulcers in Patients With 3D Insole and LSCI.
Diabetes is a serious and chronic disease that affects more than 347 million people in the world. It is the leading cause of death by age and its prevalence is increasing annually throughout the world.
- Conditions
- Diabete Type 2, Diabetic Foot, Neuropathy, Diabetic, Vascular Disease, Peripheral
- Trial name
- MYFOOT-C (NCT05843929)
- Testing
- LSCI
- Volunteers
- 86 people
- Sponsor
- Esther Soler
Systemic Lupus Erythematosus, Interferon Deficiency
Type 1 Interferon Induced Changes to Exercise Adaptations in Systemic Lupus Erythematosus Patients
Investigating the physiological effects of the interferons type 1 and 2 (IFNs), and the cytokines Interleukin 6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with systemic lupus…
- Trial name
- LUPEX (NCT05478018)
- Testing
- High Intensity Interval Training (HIIT)
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vegan Diet, Body Composition
Acute Metabolic Response Versus Long-term Adaptation to a Vegan Diet
At baseline, venous blood samples were collected from all eligible participants. The following biochemical parameters were analysed: serum electrolytes (mineral profile), fasting glucose, creatinine, urea nitrogen, total…
- Conditions
- Vegan Diet, Body Composition, Quality of Life (QOL), Cardiometabolic Health
- Trial name
- VITAL (NCT07731633)
- Testing
- vegan diet
- Where
- Slovakia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Familial Hypercholesterolemia
An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)
The main objective of this randomized clinical trial is to evaluate the effects of the adapted Brazilian Cardioprotective Diet (DICA Br) supplemented or not with phytosterols and/or krill oil in patients with a probable or…
- Trial name
- DICA-FH (NCT06331195)
- Testing
- Phytosterol, Krill oil
- Where
- 24 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital do Coracao
Diabetes Mellitus, Type 2
Translation, Cultural Adaptation and Validation of the Creole Versions of the EQ-5D and the SF-36 Questionnaires in Patients With Type II Diabetes in Reunion Island, Martinique and Guadeloupe
The evaluation of quality of life in health is particularly important for measuring the impact of the chronic diseases. The scales of measure constitute the main measurement tool in clinical trials because of their psychometrics…
- Trial name
- CreoQol (NCT02898493)
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Type 1 Diabetes Mellitus
Behavior Therapy for Families of Diabetic Adolescents
Effective adaptation to type 1 diabetes mellitus requires adolescents and their families to work together effectively to solve problems and resolve disagreements in order to achieve acceptable diabetic control and treatment…
- Trial name
- NCT00358059
- Testing
- Behavioral Family Systems Therapy for Diabetes
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Nemours Children's Clinic
Healthy Volunteers, Muscle Hypertrophy
Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training.
- Conditions
- Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend
- Trial name
- HyperLa (NCT07721766)
- Testing
- Hypertrophy-focused Resistance Training
- Where
- 8 sites in Finland, Germany and 2 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Type 1 Diabetes, Adolescent Development
Emoticare: Serious Game for the Adaptation to the Disease of Adolescents With Type 1 Diabetes Mellitus.
The intervention program targets adolescents with chronic Type 1 Diabetes Mellitus. Given the critical developmental stage and life transitions, necessitating robust personal resources, psychological support becomes imperative.
- Trial name
- NCT06331429
- Testing
- EmoTiCare
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- University of Valencia
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Effects of Descending Stair Walking
The global rise in the prevalence of physical inactivity is major public health concern. Lifestyle-related activities, such as stairs walking, has important public health implications and may represent an alternative approach for…
- Trial name
- DSW (NCT06574854)
- Testing
- DSW, ASW
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Dietary Exposure, Metabolic Disturbance
Chronic Sucrose Intake, Markers of Health and Biomarker Identification
With free sugar intake proving to be of a concern within the general public, discovery and validation of a new biomarker will allow for more consistent measurement of sucrose intake.
- Trial name
- NCT04486105
- Testing
- sucrose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Type 2 Diabetes, Hyperlipidemia
Using Learning Teams for Reflective Adaptation for Diabetes and Depression
The study will randomize 54 primary care practices to two intervention and a comparison groups. Both interventions will involve an on-site Improvement Facilitator who will assist the practice in forming an Improvement Team, using…
- Conditions
- Type 2 Diabetes, Hyperlipidemia, Hypertension, Depression
- Trial name
- ULTRA-DM/MDD (NCT00414986)
- Testing
- Standard CQI intervention, Chronic Care Improvement (CCI) Intervention, Self-directed practice comparison
- Where
- United States
- Volunteers
- 1,565 people
- Sponsor
- University of Colorado, Denver
NIDDM
APAD2: Effects of Rehabilitation Programme in Adapted Physical Activity (APA) Among Type 2 Diabetics
The principal objective is to assess and analyze the effects of a six month programme in Adapted Physical Activity (APA) on physical activity, compliance, and insulin resistance among type 2 diabetics.
- Trial name
- NCT00234273
- Testing
- Rehabilitation programme in Adapted Physical Activity (APA), Therapeutic education primarily focused on dietary
- Where
- 4 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obesity and Overweight
Adaptation of Human Brown Adipose Tissue to Calorie Restriction
The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity.
- Trial name
- BATON (NCT06878989)
- Testing
- Caloric restriction diet, Weight maintenance diet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Resting Metabolic Rate, Appetite
Effects of Overnight Low Oxygen Exposure on Energy Balance
This research study will evaluate changes in resting metabolic rate, appetite, and heart rate variability following overnight exposure (8 h/night) to normobaric hypoxia (NH) or normobaric normoxic (NN).
- Conditions
- Resting Metabolic Rate, Appetite, Heart Rate Variability
- Trial name
- NCT04151927
- Testing
- Normobaric Hypoxia, Normobaric Normoxia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida State University
Hypoxia, Cryostimulation
Evaluation of the Response to Hypoxia at Rest and During Exercise in a Healthy Subject After a Cryostimulation Exposure
Many information is available regarding human adaptations to cold or hypoxia. Adaptations to these environments and physical exercise constitute responses to physiological stress aimed at amplifying the organism's reactions and…
- Conditions
- Hypoxia, Cryostimulation, Metabolism, Autonomic Nervous System
- Trial name
- CRYOX (NCT06174480)
- Testing
- Cryostimulation
- Where
- 2 sites in France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Exercise
The Munich Cardiovascular Adaptation in Young Athletes Plus Study
The aim of the 3-year longitudinal study is to investigate the cardiovascular system's response to training loads in young athletes.
- Trial name
- MuCAYAplus (NCT06259617)
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Prediabetic State, Metabolic Syndrome X
Culturally-adapted Diabetes Prevention Lifestyle Intervention for Latinos (E-LITE Latinos)
The purpose of the study is to develop a culturally adapted intervention (CAI) program to improve weight and physical activity in overweight or obese adult Latinos at high risk for developing type 2 diabetes and/or cardiovascular…
- Conditions
- Prediabetic State, Metabolic Syndrome X, Insulin Resistance
- Trial name
- NCT02459691
- Testing
- Vida Sana, Usual Care Only
- Volunteers
- 191 people
- Sponsor
- Palo Alto Medical Foundation