Clinical trials: Metabolic Adaptation
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure
The goal of this observational study is to learn about SGLT2 inhibition medications in patients with symptomatic heart failure who are clinically prescribed FDA-approved SGLT2 inhibitors.
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
- Trial name
- EMAS-HF (NCT05885607)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Overweight and Obese Adults, Physical Inactivity
A 12-week Field Trial of the Movámonos Physical Activity Support Program
The objective of this study is to design and refine an activity support program, called Movámonos, for adults with overweight or obesity who speak Spanish.
- Trial name
- Movámonos (NCT07561996)
- Testing
- Movámonos Physical Activity Support Program
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Weight Change, Body
Energy Expenditure and Weight Loss Maintenance
Obesity is reaching epidemic proportions and threatens both health and quality of life of people around the world. While many individuals succeed at short term weight loss, weight loss maintenance is the greatest barrier to…
- Conditions
- Obesity, Weight Change, Body, Weight Loss, Physical Activity
- Trial name
- NCT03422380
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Colorado, Denver
CRC (Colorectal Cancer), Liver Metastases From Colorectal Primary Cancer
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases
This study focuses on patients with colorectal cancer undergoing surgery for the primary tumor and/or liver metastases. Tumor samples collected during surgery will be used to generate patient-derived models (primary cultures…
- Trial name
- AIRC_ IG 34634 (NCT07497789)
- Volunteers
- 156 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Overweight, Adolescent Behavior
Family-Based Mindful Eating Intervention for Overweight Adolescents
With currently 35% of U.S. adolescents being overweight and one in six having metabolic syndrome, adolescent obesity is one of the major global health challenges of the 21st century.
- Conditions
- Overweight, Adolescent Behavior, Family Research, Weight Loss
- Trial name
- NCT02114190
- Testing
- Adolescent Mindful Eating Group, Parent Integrated Group
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Oregon Research Institute
Diabetes Mellitus
Educational Intervention and Social Support in Diabetes Mellitus
The purpose of this study is to evaluate the impact of an educational program for people with diabetes mellitus based on the family social support.
- Trial name
- NCT01387633
- Testing
- Educational intervention for family members/caregivers of people with diabetes mellitus through telephone contact, Educational intervention group for people with diabetes through Diabetes Conversation Maps
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 2, Motivation
Motivational Interviewing in Type 2 Diabetes Patients
This research was planned to examine the effects of diabetes education given by motivational interviews on adherence to the disease, perception of diabetes self-efficacy and metabolic parameters in diabetes patients.
- Trial name
- NCT05844748
- Testing
- diabetes education with motivational interview technique
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Prediabetes, Obesity
Diabetes Prevention Program in Adults of the Yaqui Tribe of Hermosillo, Sonora at Risk of Diabetes
Diabetes is a major non communicable chronic diseases in the world. It occupies the fourth or fifth leading cause of death in most high-income countries and there is strong evidence that has epidemic proportions in many…
- Conditions
- Prediabetes, Obesity, Overweight
- Trial name
- NCT02899390
- Testing
- Lifestyle Intervention
- Where
- 3 sites in Mexico
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Obesity
Effectiveness of Adapted Basketball Programs in Adolescents With Obesity (ABBA)
This study aims to evaluate the effects of different basketball training programs on adolescents with obesity. The objective is to assess how these programs influence body weight, physical fitness, motivation to exercise, and…
- Trial name
- ABBA (NCT07046871)
- Testing
- 1. Intervention Name (Arm 1) Name: Adapted Basketball Program with Video Support Type: Behavioral Description: A 7-week basketball intervention for adolescents with obesity, combining pedagogically a, ADAPT Adapted Basketball Program
- Where
- Tunisia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Obesity
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks…
- Trial name
- NCT01452074
- Testing
- Exercise Training, Weight Loss with continued Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
Cold Acclimation as a Modulator of Brown Adipose Tissue Function in Adults With Obesity
This study will investigate the effects of at least 12 weeks of weekly cold water immersions (water temperature 18ºC) on BAT perfusion in individuals with obesity.
- Trial name
- MOTORBAT (NCT05468151)
- Testing
- Cold acclimation, Intervention Control group - volunteers with obesity, Acute cold exposure
- Where
- Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Neurodegenerative Diseases, Leukodystrophy
Home Exercise for Individuals With Neurodegenerative Disease
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
- Conditions
- Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL
- Trial name
- NCT05443906
- Testing
- Home exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Non-Alcoholic Fatty Liver Disease
Biological Adaptations of Strength Training.
A two-trial repeated measures design will be employed in this investigation. Both the control trial and the exercise trial will last for 3 months.
- Trial name
- NCT04098484
- Testing
- Control Trial, Exercise Trial
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
COVID
Functional and Respiratory Rehabilitation and Nutritional Care of COVID-19 Patients (RECOVER-19)
Following the acute phase of COVID, some patients may have sequelae, such as breathing difficulties or malnutrition. We hypothesize that a functional and respiratory rehabilitation program associated with personalized nutritional…
- Trial name
- RECOVER-19 (NCT04466800)
- Testing
- Intervention group_rehabilitation program
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Obesity
Take HEED (Healthy Eating and Exercise Decisions)
This is a randomized intervention that examines the effect of culturally adapted weight loss program in African American (AA) females age 40-65.
- Trial name
- NCT00306709
- Testing
- culturally adapted behavior change
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- Kaiser Permanente
Obesity
Impact of the Residual Gastric Volume in Laparoscopic Sleeve Gastrectomy's Failure
Obesity is a worldwide health problematic whose incidence is increasing especially in developed countries. The surgical management of this illness consists in different techniques such as Laparoscopic Sleeve Gastrectomy but this…
- Trial name
- GASTROMANCH (NCT01539967)
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Protein Metabolism
Protein Ingestion Before Training Low
A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks.
- Trial name
- NCT03147001
- Testing
- Protein ingestion
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Overweight and Obesity
Chronotype-adapted Diet and Weight Loss
In humans, prolonged alterations in the circadian rhythm have been linked to cognitive impairments, premature ageing, and oncological and metabolic disorders such as diabetes and obesity.
- Trial name
- CHRONODIET (NCT05941871)
- Testing
- Dietary intervention - intervention group, Dietary intervention - control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi