Clinical trials: Metabolic Control
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Iron Deficiency
Intravenous High Dose Iron in Blood Donors
2-3% of the population participates in blood donation programmes. Traditionally, safety issues in transfusion medicine have been concentrating on product and recipient safety.
- Trial name
- IronWoMan (NCT01787526)
- Testing
- ferric carboxymaltose, oral iron
- Where
- Austria
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes Mellitus, Hypertension
Impact of Medication Therapy Management Intervention on Treatment Outcomes and Medication Adherence Among Adult Patients Comorbid With Diabetes Mellitus and Hypertension at Outpatient Clinics
The goal of this interventional study was to assess the impact of medication therapy management on treatment outcomes and medication adherence among adult patients comorbid with diabetes mellitus and hypertension at outpatient…
- Trial name
- NCT06112925
- Testing
- Medication Therapy Management
- Where
- Ethiopia
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Mattu University
Individuals at Risk of Developing Diabetes
Daily vs Intermittent Restriction of Energy: Controlled Trial to Reduce Diabetes Risk (DIRECT)
In this randomized controlled trial, the investigators will compare the long term effectiveness of intermittent fasting (IF) versus an energy matched moderate calorie restriction (CR) over 18 months, and relative to a non-active…
- Trial name
- NCT03689608
- Testing
- Intermittent Fasting (IF), Daily Restriction (DR), standard care (SC)
- Where
- Australia
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Obesity, Obesity, Childhood
A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
The goal of this clinical trial is to test a responsive parenting obesity prevention program with infants and caregivers of color (e.g., non-White; Hispanic/Latinx) and/or who are economically marginalized (i.e., publicly…
- Conditions
- Obesity, Obesity, Childhood, Weight Gain, Weight Gain Trajectory
- Trial name
- THRIVE (NCT06028113)
- Testing
- THRIVE 2.0
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Cancer, Breast, Cancer, Ovarian
Family History App in Personalized Medicine
A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment.
- Conditions
- Cancer, Breast, Cancer, Ovarian, Cancer, Colorectal, Cancer, Prostate
- Trial name
- FHAMe (NCT04726319)
- Testing
- FHAMe Intervention
- Where
- Canada
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Iron Deficiency Anemia
Preconception vs First-Trimester Screening and Treatment for Iron Deficiency Anemia
This cluster randomized trial compares preconception with early-pregnancy anemia screening and iron supplementation, assessing late pregnancy iron deficiency anemia and maternal and infant outcomes.
- Trial name
- NCT07811765
- Testing
- Preconception Anemia Screening and Treatment Strategy, Early-Pregnancy Anemia Screening and Treatment Strategy
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Morbid Obesity, Labor Pain
DPE Technique in Labor Epidural for Morbidly Obese Women
The primary purpose of this study is to determine differences in block quality between the "dural-puncture epidural" (DPE) and standard epidural (EPL) techniques for labor analgesia in the morbidly obese patient.
- Trial name
- NCT03074695
- Testing
- Dural puncture epidural (DPE), Standard Epidural (EPL)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Duke University
Mild Cognitive Impairment
Cognitive Effects of Aerobic Exercise for MCI Adults
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at greater risk for developing Alzheimer's disease, and to evaluate whether change in insulin sensitivity…
- Trial name
- NCT00220467
- Testing
- Aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Diabetes Mellitus, Type 2
Online Program Assisting Lifestyle Changes (Asterix 1.0 & Obelix 2.0)
The purpose of this study is to help Internet users to adopt and maintain a healthy lifestyle, it is imperative to increase self-management competencies to improve healthy eating and regular physical activity.
- Trial name
- OPAL (NCT00986375)
- Testing
- Intervention Group (IG), Active Control Group (ACG)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Obesity, Metabolic Disease
Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Xla1 Christensenella minuta, phase I, randomized, placebo-controlled double-blind protocol, evaluating safety, tolerability and impact on the gut microbiota in healthy volunteers, overweight and obese adults.
- Trial name
- CAUSALITY (NCT04663139)
- Testing
- Xla1
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- YSOPIA Bioscience
Prediabetes, Obesity & Overweight
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects.
- Conditions
- Prediabetes, Obesity & Overweight, Inflamation, Oxidative Stress
- Trial name
- BIOTRANSFORM (NCT07659028)
- Testing
- supplementation, food
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Metabolic Syndrome
Effects of Low Fat Milk Consumption on Metabolic Syndrome
This study aimed to investigate the effects of low-fat milk consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome.
- Trial name
- NCT02028585
- Testing
- Low-fat milk group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ministry of Food and Drug Safety, Korea
Diabetes Mellitus, Gestational Diabetes Mellitus (GDM)
A Proof of Concept (PoC), Randomized, Controlled Study to Validate the Algorithm and Evaluate the Accuracy, Safety and Pain Level of the Smartest-AE in Comparison to Self-measure Blood Glucose Levels
The study is conducted in Israel so plain language for the study is exist in Hebrew only
- Conditions
- Diabetes Mellitus, Gestational Diabetes Mellitus (GDM), Pre Diabetes
- Trial name
- NCT06587087
- Testing
- Smartest-AE: The lancet that will be used will be the Vitrex Soft Lite lll 28G.
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Smartest Technologies
Amyotrophic Lateral Sclerosis (ALS)
A First in Human Study of ORT247 in Healthy Volunteers
This is a single center, double-blinded, randomized, placebo controlled single ascending dose clinical study, with the primary purpose of evaluating the safety, tolerability, pharmacokinetics (PK), and immunohistochemistry of…
- Trial name
- NCT06769620
- Testing
- ORT247
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Orthogonal Neuroscience Inc.
Amyotrophic Lateral Sclerosis
Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy Controls With PET (18F-RoSMALS)
This clinical trial is a phase 1 study in which investigations with the weakly radioactive substance [18F]-RoSMA-18-d6 are being carried out for the first time.
- Trial name
- 18F-RoSMALS (NCT05880563)
- Testing
- [18F]-RoSMA-18-d6
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Markus Weber
Ischemia
Trial of the Effects of Remote Preconditioning on the Tissue Metabolism During Exercise and Ischemia
Previously, the preconditioning signaling pathways have been studied on molecular level or in animal model. By using MR spectroscopy and imaging in a dynamic human model of preconditioning, we will have a better understanding how…
- Trial name
- NCT00791206
- Testing
- Real preconditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Obesity, Weight Loss
Effects of Adding L-BAIBA to Exercising Adult Overweight and Obese Men and Women
Beta-amino isobutyric acid (BAIBA) is a myokine produced in skeletal muscle and has been shown to impact how our body metabolizes fuel.
- Conditions
- Obesity, Weight Loss, Weight, Body, Cardiometabolic Syndrome
- Trial name
- LBC (NCT05775016)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Healthy Participants
A First-in-Human, Single- and Multiple-Ascending Dose Study of YH35995 in Healthy Adult Male Participants
This is a randomized, double-blind, first-in-human study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of YH35995
- Trial name
- NCT06517914
- Testing
- YH35995
- Where
- South Korea
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
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