Clinical trials: Metabolic Control
Cryotherapy, Training
Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight
Therapeutic effectiveness of coldness in relieving pain and reducing inflammation has been known for many years now. Over that time, various coldness therapies have gained in popularity, including winter swimming, snow baths or…
- Conditions
- Cryotherapy, Training, Overweight, Insulin
- Trial name
- NCT04375969
- Testing
- whole body cryostimulation treatment, Connection WBC treatment and HIIT training, Control Group
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Abdominal Obesity
Eon™ FR 1064 Full Abdomen Clinical Study Protocol
This is a marketing study intended to provide additional data for marketing purposes for the eon™ FR is FDA 510(k) which has been cleared for non-invasive lipolysis of the abdomen to achieve disruption of adipocyte cells intended…
- Trial name
- NCT04842110
- Testing
- Experimental: eonTM FR 1064 nm device
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Dominion Aesthetic Technologies, Inc.
Healthy Adults
Safety and Tolerance of a Novel Three-Strain Probiotic in Healthy Adults
This Phase I \& II study evaluates the safety and tolerability of 8 weeks of daily supplementation with high-dose versus standard-dose of a novel three-strain probiotic.
- Trial name
- NCT07566884
- Testing
- Three-Strain Probiotic
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pendulum Therapeutics
Metabolic Syndrome
Effects of Moderate Altitude Training on Metabolic Parameters in Voluntary Study Participants With Metabolic Syndrome
The metabolic syndrome is a cluster of metabolic disorders (obesity, hyperglycemia, dyslipidemia and hypertension) and it is a risk factor for the development of type 2 diabetes and atherosclerotic cardiovascular disease.
- Trial name
- NCT02013947
- Testing
- 2 weeks of exercise in low and moderate altitude
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pure Mountain Solda
Diabetes Mellitus, Type 2
Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects
Single ascending dose first time in human study for GZR18 in healthy subjects
- Trial name
- NCT05328726
- Testing
- GZR-18
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Non-Alcoholic Fatty Liver Disease, Childhood Obesity
Clinical Epidemiology of NAFLD in Children and Adolescents
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly increasing alongside overweight and obesity, not only in adults but also in children and adolescents.
- Trial name
- LiverKids (NCT05526274)
- Testing
- Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP)
- Where
- Spain
- Volunteers
- 2,866 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Obesity
Enhanced Internet Behavior Therapy for Treating Obesity
The purpose of this study is to compare two Internet-based behavioral weight loss programs.
- Trial name
- NCT00212238
- Testing
- internet behavioral weight loss program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metabolic Disease, Immune Function
Omega 3 and Fibre Intervention Study to Improve Metabolic Health
Metabolic syndrome represents a major health burden worldwide affecting 20-30% of the population. This clustering of abnormalities that confers an increased risk of cardiovascular disease and type 2 diabetes mellitus, is the…
- Conditions
- Metabolic Disease, Immune Function, Cardiovascular Diseases, Systemic Inflammation
- Trial name
- NCT03442348
- Testing
- Omega 3 fatty acid, Inulin fibre
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
PreDiabetes, Obesity
The Time-Restricted Intake of Meals Study
TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.
- Trial name
- TRIM (NCT03527368)
- Testing
- Time-restricted feeding, Usual feeding pattern
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Maternal Cardiometabolic Health, Molecular Impact of Psychological Stress and Socioeconomic Adversity
Conscious Pregnancy: Supporting Maternal Cardiometabolic Health With Mindfulness
A pilot randomized control trial (RCT) to examine the efficacy of a culturally tailored mindfulness intervention upon fasting cardiometabolic factors (including markers of glycemic control) and inflammatory gene expression in…
- Conditions
- Maternal Cardiometabolic Health, Molecular Impact of Psychological Stress and Socioeconomic Adversity, Maternal Inflammatory Markers, Maternal Diabetes
- Trial name
- NCT06898658
- Testing
- Mindfulness Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Diabetes Mellitus, Noninsulin-Dependent, Diabetes, Type 2
A Lifestyle Intervention for Type 2 Diabetes Patients in Kuwait and Its Impact on Glycaemic Control
This was an unblinded, randomised controlled study, the purpose of which was to investigate the impact of a structured health education intervention on the glycaemic control of Type 2 diabetes patients within a Kuwaiti cultural…
- Trial name
- NCT03397225
- Testing
- Lifestyle intervention
- Where
- 2 sites in Kuwait, United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Overweight and Obesity
Neuromodulation With Transcranial Direct Current Stimulation (tDCS) to Control Excess Weight
The purpose of this study is to examine the effects of noninvasive neuromodulation with transcranial direct current stimulation (tDCS) aimed at enhancing the excitability of the left prefrontal cortex in middle-aged women with…
- Trial name
- NCT03351426
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Obesity Prevention, Obesity and Overweight
Pilates Effect on Women With and Without Obesity
Obesity, a health problem, is caused by insufficient physical activity and unhealthy nutrition. For individuals with obesity, non-weight-bearing and enjoyable exercises, such as Pilates, should be implemented as physical activity…
- Conditions
- Obesity Prevention, Obesity and Overweight, Exercise, Pilates Exercise
- Trial name
- NCT06851026
- Testing
- Pilates Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Diabetes
Comparison of Premixed Insulin With Basal-plus Insulin in Type 2 Diabetes Patients
Comparison of efficacy and safety of different insulin regimens between basal bolus and premixed insulin in poorly controlled type 2 diabetes
- Trial name
- COMPAR (NCT02219750)
- Testing
- switch twice-daily insulin
- Where
- Taiwan
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Obesity
Home-based Training in Obese Individuals
Generally, the enhancement of physical fitness depends on the optimal modulation of different physiological, technical or psychological stimuli and within the factors the would contribute to a decrease performance level, obesity…
- Trial name
- FITOB (NCT05773690)
- Testing
- Movement quality, Conventional Resistance Training
- Where
- Italy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Mitochondrial Respiratory Chain Deficiencies
Abdominal Adiposity and Muscle Mitochondrial Functions
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance.
- Trial name
- Mithycal (NCT00446745)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Type 2 Diabetes Mellitus
Glycemic Control and Endothelial Function in Patients With Type 2 Diabetes
Study objective To evaluate the mechanism behind endothelial dysfunction in patients with type 2 diabetes in relation to the level of glycaemic control. Primary endpoint: Change in endothelium dependent vasodilatation (EDV).
- Trial name
- AIDdiabetes (NCT03480945)
- Testing
- serotonin
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity, Overweight and Obesity
Assess the Effect of a Whole Fruit Powder on Gut Microbiome Function on Overweight & Obese Adults
The goal of this clinical trial is to evaluate the effect of freeze-dried blueberry powder on the gut microbiome in overweight and obese adults.
- Trial name
- NCT06256653
- Testing
- Freeze-dried blueberries
- Where
- Ireland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College Cork
Normal Healthy Adults
A Research Study to Evaluate BLX-0871 in Healthy Adults
This study will test an oral medicine called BLX-0871, which is being developed to improve metabolic health by activating AMP-activated protein kinase (AMPK), a key regulator of energy balance.
- Trial name
- NCT07140081
- Testing
- BLX-0871
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
Obesity, Overweight
A Maintenance Program for the Be Fit Employee Wellness Program
This research study is being done: 1) to determine if the MGH Be Fit program helps employees to change their nutrition and exercise habits and lower their risk for chronic diseases, such as heart disease and diabetes and 2) to…
- Trial name
- NCT00707577
- Testing
- Internet-based maintenance program
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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