Clinical trials: Metabolic Flexibility
Osteoporosis
Effects of Clinical Pilates and Whole Body Vibration Exercises in Postmenopausal Osteoporotic Women
The aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.
- Trial name
- NCT04259697
- Testing
- Clinical pilates, Whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Dokuz Eylul University
Food Intake Regulation, Substrate Oxidation
Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men
The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.
- Trial name
- NCT01888991
- Testing
- Glucose Preload and Exercise Intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy
MitoQ & Cardiopulmonary Responses During Exercise
Study Purpose: To examine the acute effects of antioxidant supplementation on energy use during a single bout of exercise in apparently healthy adult men and women.
- Trial name
- NCT06069245
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ball State University
Obesity, Diabetes Mellitus, Type 2
This Study Assessed the Impact of Diet on Gastric Emptying Time and Metabolic Flexibility
Consumption of slowly digestible carbohydrates can elicit higher satiety feeling compared to rapidly digestible carbohydrates, however not all individuals respond the same.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
- Trial name
- IODC (NCT03630263)
- Testing
- Raw Corn Starch, No Raw Corn Starch
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Purdue University
Poor Glycemic Control, Quality of Life
Benefits of a Bolus Calculator in Pediatric Patients on Multiple Daily Insulin Injections
It it hypothesized that children and adolescents with type 1 diabetes, who are counting carbohydrates can achieve better metabolic control by concurrent use of the Accu-Chek Aviva Expert.
- Trial name
- NCT06141629
- Testing
- accu chek Aviva Expert, Accu Chek Aviva Nano
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Physical Fitness, Mitochondrial Function, Bioenergetics
Effects of Acute Exercise in Fasting and Fed States in Individuals With Different Aerobic Fitness Levels
The aim of this study is to investigate the effects of aerobic fitness level, feeding status, and acute exercise on whole-body metabolic fuel utilization and mitochondrial function in peripheral blood mononuclear cells (PBMCs) in…
- Conditions
- Physical Fitness, Mitochondrial Function, Bioenergetics, Mitochondria, Energy Metabolism
- Trial name
- NCT07813403
- Testing
- Acute Moderate-Intensity Cycling Exercise, Ad Libitum Mixed Meal
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obesity
Metabolic Flexibility and Metabolic Heath in Human Obesity
This interventional study explores the relationship between improvements in metabolic health following weight loss and changes in whole-body fat mass and its distribution.
- Trial name
- PROB (NCT07355933)
- Testing
- Body Weight Loss
- Where
- Chile
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jose Galgani
Obesity, Bariatric Surgery
Effect of Bariatric Surgery on Physical Activity, Gait, Flexibility and Quality of Life
This study aimed to analyze spatio-temporal characteristics of gait, physical activity level and changes in quality of life in patients by measuring conditions before bariatric surgery and third-month after the surgery.
- Conditions
- Obesity, Bariatric Surgery, Gait
- Trial name
- NCT05358288
- Volunteers
- 30 people
- Sponsor
- Ankara Yildirim Beyazıt University
Metabolic Flexibility
Astaxanthin Reduces Exercising Heart Rate.
Briefly, this study involved 2 trials: baseline (Trial 1) and post-astaxanthin intervention (Trial 2). Both trials included participants completing a graded exercise test while connected to a metabolic cart, to measure…
- Trial name
- NCT05282355
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Alabama
Prediabetes
Prebiotics, Gut Microbiota, and Cardiometabolic Health
Forty-eight prediabetic men and women (50-75 years of age) will participate in a 6-week feeding study in which they will randomized to receive either 10 g/day of inulin or placebo.
- Trial name
- NCT02346838
- Testing
- Inulin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Virginia Polytechnic Institute and State University
Health Behavior
Effect of Breaking up Prolonged Sitting on Metabolic Flexibility
The investigators propose in this project to determine the effect of 3 days of frequent interruption of prolonged sitting on metabolic health in healthy overweight sedentary adults (n=24), as compared to 3 days including a single…
- Trial name
- NCT02258438
- Testing
- Uninterrupted sitting, Sitting + 1 bout of activity, Sitting + microbursts of activity
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Metabolic Flexibility to Predict Lifestyle Interventions Outcomes
Weight loss is a cornerstone of diabetes (T2D) management, yet in clinical practice, its delivery is limited by its perceived burdensome nature and variability in response.
- Trial name
- MEPHISTO (NCT06329349)
- Testing
- Exercise, Combined Exercise + Diet
- Where
- 3 sites in Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Metabolic Flexibility
Human Metabolic Flexibility: Its Role in Energy Regulation and Obesity
Obesity is commonly described as a consequence of excess calorie intake. Conventionally, the physiological variables that have been of extensive interest are food intake and energy expenditure.
- Trial name
- NCT04773132
- Testing
- Low Protein
- Where
- Singapore
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Inadequate or Impaired Respiratory Function, Diabetes
Effects of Respiratory Muscle Training in Obese Women
The objective of this study will be to evaluate the effects of inspiratory muscle training (IMT) on the physical fitness of obese women It is believed that the application of these exercises helps in the improvement of…
- Conditions
- Inadequate or Impaired Respiratory Function, Diabetes, Hypertension
- Trial name
- NCT03767556
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Spine Injury, Hamstring Injury
Effect of a Flexibility Program on the Extensibility of the Hamstrings and the Thoracic and Lumbar Spinal Curvatures
The goal of this clinical trial is to analyse the effect of an intervention program based on hamstring flexibility on the extensibility and curvatures of the spine in dancers.
- Conditions
- Spine Injury, Hamstring Injury, Lumbar Hyperlordosis, Kyphosis
- Trial name
- NCT05904834
- Testing
- Flexibility training
- Where
- Spain
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Obesity, Metabolic Syndrome
Impact of Metabolic Flexibility on Changes in Metabolic Health
Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands.
- Trial name
- METPROS (NCT06340321)
- Testing
- Metabolic flexibility in the fasted state, Metabolic flexibility in euglycemic-hyperinsulinemic clamp, Metabolic flexibility in the metabolic chamber
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Inflammation, Insulin Sensitivity
Sugar-sweetened Beverages Influence Benefits of Exercise in Overweight Adults
The objective of this study was to determine how metabolic and inflammatory effects of physical exercise in overweight individuals are altered when sugar-sweetened beverages (SSB) are consumed after physical exercise.
- Trial name
- NCT03576703
- Testing
- Exercise with and without SSB ingestion
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Montana State University
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
NAFLD - Non-Alcoholic Fatty Liver Disease, Type 2 Diabetes
Hepatic and Cardiac Metabolic Flexibility in Subjects With T2DM With and Without NAFLD
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from simple reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH) and cirrhosis.
- Trial name
- NCT04698486
- Testing
- Hyperinsulinemic euglycaemic clamp
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cardiometabolic Risk Factors
Physical Exercise on Physiological Adaptation Capacity and Chronic Pain in Individuals With Cardiovascular Risk
This research focuses on studying the effects of a 12-week exercise program on the health of individuals at risk of heart disease.
- Trial name
- NCT06201273
- Testing
- High-Intensity Interval Training, Resistance Training
- Where
- Chile
- Volunteers
- 192 people
- Sponsor
- Universidad San Sebastián