Clinical trials: Metabolic Improvements
Type 2 Diabetes Mellitus (T2DM)
Ayurveda Diet & Lifestyle Protocol for Type 2 Diabetes: A Feasibility Study
This study looked at whether a 12-week Maharishi Ayurveda diet and lifestyle program was practical and acceptable for adults with Type 2 Diabetes.
- Trial name
- AYU-LIFE-T2D (NCT07400276)
- Testing
- Maharishi Ayurveda Lifestyle Program
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Maharishi International University
Overweight
Comparing HICT and MICT for Health Improvements in Overweight Young Adults
The increasing prevalence of overweight and obesity is becoming a concern worldwide as it is associated with the increased prevalence of non-communicable diseases.
- Trial name
- HiMod Impact (NCT07008326)
- Testing
- High Intensity Circuit Training, Moderate Intensity Continuous Training
- Where
- Indonesia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Obesity, Cardiovascular Risk Factor
Exercise for Preventing the Metabolic Syndrome in Latinoamerican Amerindians
Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities.
- Conditions
- Obesity, Cardiovascular Risk Factor, Physical Activity
- Trial name
- NCT03653468
- Testing
- Concurrent training (CT)
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Obesity
Engaging Tribal Policy Makers to Improve the Food and Physical Activity Environments in American Indian Communities
The overall objective of the study is to reduce adult obesity in participating American Indian (AI) communities and to improve understanding of the behavioral and environmental factors affecting obesity in these settings.
- Trial name
- OPREVENT2 (NCT02803853)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 876 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetes Mellitus, Type 2
Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM
To evaluate the effect of the combination of chromium picolinate (600 μg Cr) + biotin (2 mg) versus placebo on glycosylated hemoglobin (HbA1c), lipid profiles (Total-C, HDL-C, LDL-C, TGs, TG/HDL ratio, etc), and pharmacoeconomic…
- Trial name
- NCT00289354
- Testing
- Chromium Picolinate (600 mcg Cr) + biotin (2 mg)
- Volunteers
- 600 people
- Sponsor
- Nutrition 21, Inc.
Obesity & Overweight, Diabete Type 2
Traditional Chinese Medicine Fasting Therapy, Ketone Levels, and Metabolic Improvements
This is a retrospective study using existing medical records. The purpose is to learn how Traditional Chinese Medicine (TCM) fasting therapy affects metabolism.
- Conditions
- Obesity & Overweight, Diabete Type 2, Metabolic Syndrome
- Trial name
- NCT07840807
- Testing
- Traditional Chinese Medicine Fasting Therapy
- Where
- China
- Volunteers
- 1,149 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
Chronic Kidney Disease, Diabetes Mellitus
Facilitating Improvements in Kidney Health Using a Smartphone App Counseling Program in Patients With Diabetes
This pilot study tests the feasibility of dietary app-supported tele-counseling in the treatment of patients with stage 1-3a chronic kidney disease (CKD) and diabetes.
- Conditions
- Chronic Kidney Disease, Diabetes Mellitus, Albuminuria
- Trial name
- FitKidney (NCT03015480)
- Testing
- Remote counseling
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Geisinger Clinic
Cognitive Function, Metabolic Improvements
B-vitamins Treatment for Improvement of Cognitive Function
Observation studies documented a correlation between plasma concentrations of homocysteine and cognitive decline with age. The study hypothesis was that high doses of B-vitamins (as effective homocysteine lowering treatment) can…
- Trial name
- NCT01095211
- Testing
- B-vitamin complex
- Where
- Germany
- Volunteers
- 79 people
- Sponsor
- Universität des Saarlandes
Malnutrition
Livestock for Health Project
Children 5 years and below, and pregnant/lactating women in pastoralist communities suffer a high burden of acute malnutrition. Improving the health and productivity of animals can reduce the risk malnutrition during the dry…
- Trial name
- L4H (NCT04608656)
- Testing
- Provision of livestock feeds, Nutrition counselling
- Where
- Kenya
- Volunteers
- 1,734 people, healthy volunteers welcome
- Sponsor
- Washington State University
Type 2 Diabetes Mellitus
Paleolithic Diets vs T2D and Improvements in the Metabolic Syndrome
This study proposes to evaluate the physiological effects of eating Paleolithic type diet ("hunter-gatherer's diet") on Type 2 diabetic patients.
- Trial name
- NCT00548782
- Testing
- Paleolithic diet, ADA ( American Diabetes Association) recommended diet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoporosis
Effects of Lagenbone on Bone Mineral Density
To study the effects of the herbal supplement Lagenbone on Bone Mineral Density
- Trial name
- NCT04557553
- Testing
- Lagenbone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Southern California University of Health Sciences
Cardiovascular Disease, Diabetes
Robust Evaluation to Measure Improvements in Nonadherence From Low-cost Devices
The aim of this study is to determine whether adherence to oral maintenance medications differs for patients randomized to receive a RxTimerCap, a Take-N-Slide, a standard pillbox, or none of these devices, with the hypothesis…
- Conditions
- Cardiovascular Disease, Diabetes, Breast Cancer, Depression
- Trial name
- REMIND (NCT02015806)
- Testing
- RxTimerCap, Take-N-Slide, Pillbox
- Where
- United States
- Volunteers
- 53,480 people
- Sponsor
- Brigham and Women's Hospital
Obesity
Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women
For over four decades the medical literature has observed a relationship between obesity and poorer health outcomes. The causal mechanisms of these poorer outcomes however are unclear.
- Trial name
- NCT00769717
- Testing
- Wellness-Centered (HUGS), Weight-Centered (LEARN)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Reading Hospital and Medical Center
Dyslipidemias, Obesity
Metabolic Optimization Through Diet/Lifestyle Improvements For Youth
The overarching goal of this study is to evaluate plasma ceramides (Cers) as early nutrition-sensitive biomarkers of metabolic health.
- Trial name
- MODIFY (NCT04270084)
- Testing
- Alive-Family
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's National Research Institute
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Obesity, Insulin Resistance
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
African Americans are at a substantially greater type 2 diabetes risk compared to Caucasians; however, very little data are available on the effects of exercise training on type 2 diabetes risk factors in at risk African…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- HI-PACE (NCT02892331)
- Testing
- Moderate intensity exercise training (MOD-INT), High Intensity exercise training (HI-INT)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- East Carolina University
PCOS, Diet Modification
Low Starch Dietary Education Program vs. Traditional Treatment for PCOS
Compare weight loss and metabolic parameters in patients using a low starch dietary education program vs. traditional treatment (i.e., prescribing metformin, low calorie diet and exercise) for health improvement in women with…
- Conditions
- PCOS, Diet Modification, Metabolism, Nutrition Disorders
- Trial name
- NCT03916263
- Testing
- Metformin, One-On-One Dietary Instruction, Video Dietary Instruction
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
PreDiabetes
Cleaner Air for Lower Cardiometabolic Risk
The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes.
- Trial name
- NCT05994937
- Testing
- PAC with HEPA filter intact, PAC with HEPA filter removed
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Obesity, Pre-diabetes
Valued EpiGenetic Glycemic ImprovEments Through Weight Loss
This randomized controlled clinical trial will use methylomic and transcriptomic profiling to examine the effects of a weight loss intervention on the cholesterol metabolism gene network in monocytes and adipocytes and…
- Trial name
- VEGGIE (NCT02869659)
- Testing
- Weight Loss Group, Delayed Weight Loss
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Arterial Disease (CAD)
Health Improvements by Understanding the Determinants of Residual Risk in Coronary Artery Disease and New Targets for Prevention and Treatment
Current medical treatments, in patients with stable coronary artery disease (CAD), mainly target established risk factors and are able to reduce morbidity and mortality but still leave a substantial residual risk of coronary…
- Trial name
- HURRICANE (NCT06601153)
- Testing
- Cardiac CT
- Where
- 2 sites in Italy
- Volunteers
- 961 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio