Clinical trials: Metabolic Regulation
Healthy, Lipodystrophy, Familial Partial
Lipodystrophy and Fat Metabolism During Exercise
Mandibular dysplasia with deafness and progeroid features (MDP) syndrome is a rare genetic metabolic disorder that causes lipodystrophy: the inability of the body to store subcutaneous adipose tissue (fat under the skin).
- Trial name
- FAT (NCT04056000)
- Testing
- Caffeine, High-carbohdyrate breakfast, 60-minutes of steady state exercise
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter
Obesity
Role of Sweetness in Glucose Regulation
Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of…
- Trial name
- STS (NCT03844230)
- Testing
- Control - Inhibition, Experimental I- Inhibition, Experimental II- Inhibition
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
Impact of Protein Content of Ultraprocessed Foods on the Regulation of Energy Balance
Aim of the study is to investigate the effects of high-protein, ultraprocessed foods on the regulation of energy balance in a metabolic chamber.
- Trial name
- NCT05337007
- Testing
- high protein diet, moderate protein diet
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Obesity and Type 2 Diabetes, Diet Modification
Mobile Regulation of Craving Training (mROC-T) to Improve Dietary Intake in Rural Adolescent Girls
The goal of this clinical trial is to test if a regulation of craving training intervention in the form of a mobile phone app can increase fruit and vegetable intake in adolescent girls ages 14-18 years of age.
- Trial name
- ROC Teens! (NCT06723028)
- Testing
- Regulation of craving training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Diabetes Mellitus, Type 2
Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
- Trial name
- NCT02592616
- Testing
- CON, CW, IW
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes
Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes
Inadequate suppression of intramuscular and adipose tissue lipolysis, and consequent excessive delivery of fatty acids to ectopic tissues (e.g.
- Trial name
- NCT01680133
- Testing
- Hyperinsulinemic euglycemic clamp
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes Mellitus
Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance
The study is being conducted to find out why too much fat in your blood stream may cause insulin resistance in your muscles. Insulin is the hormone, produced normally by your body, which causes your blood sugar to return to…
- Trial name
- NCT01240252
- Testing
- Human insulin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Arthritis, Chronic Inflammation
Adenosylmethionine Metabolism in Human Inflammation
The investigators propose to conduct a translational study on the regulation of S-adenosylmethionine synthesis and cellular methylation reactions during chronic inflammation.
- Trial name
- NCT02520206
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Obesity, Overweight
A Study of the Effects of Fish Protein Intake on Glucose Regulation in Overweight and Obese Adults.
The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults.
- Trial name
- FISK3 (NCT01641055)
- Testing
- Salmon protein hydrolysate, Herring protein hydrolysate, Cod protein
- Where
- Norway
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Polycystic Ovary Syndrome
Development of a Structured Education Programme for Women With Polycystic Ovary Syndrome
Polycystic Ovary syndrome (PCOS) is a common hormonal imbalance affecting about 12% of women in the UK. The number of women with PCOS is rising.
- Trial name
- SUCCESS (NCT01462864)
- Testing
- Structured Lifestyle Education
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University of Leicester
Diabetes Mellitus, Type 2
Efficacy of Educational Nutrition and Exercise on the Regulation of Appetite Through Exosomes in Type 2 Diabetics
The aim of this randomized controlled trial is to investigate the effects of different aerobic modalities: moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), and a nutritional intervention…
- Trial name
- APETEX (NCT05259449)
- Testing
- Nutritional Intervention, High-intensity interval training (HIIT), Moderate-intensity continuous training (MICT)
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- University of Cadiz
COVID-19, Diabetes Mellitus
Insulin Regulation and Severity of Severe Acute Respiratory Syndrome COVID-19 Infection
The Coronavirus Disease of 2019 (COVID-19) pandemic has caused an international healthcare crisis and produced a large healthcare burden.
- Conditions
- COVID-19, Diabetes Mellitus, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05897528
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 589 people
- Sponsor
- Arrowhead Regional Medical Center
Aging, Glucose Intolerance
Regulation of B-Cell Function & Glucose Tolerance in Older People
This VA CDA-2 proposal will test in detail if lifestyle intervention with aerobic exercise training improves the body's production of insulin in older people at risk to develop diabetes.
- Trial name
- NCT00554112
- Testing
- Exercise
- Volunteers
- 90 people
- Sponsor
- US Department of Veterans Affairs
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2
RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes
This study is a phase 3b, multicentre, randomised, open label, parallel group study. A 4-week run-in period will be followed by a median of 6 years of treatment with study medication in addition to continuation of background…
- Trial name
- RECORD (NCT00379769)
- Testing
- Rosiglitazone, Sulfonylurea, Metformin
- Where
- 446 sites in Australia, Belgium and 23 more
- Volunteers
- 4,447 people
- Sponsor
- GlaxoSmithKline
Obesity
Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
The purpose of this study is to learn more about how diet affects the hormone ghrelin. Ghrelin is made in the stomach and causes appetite to increase.
- Trial name
- NCT00694512
- Testing
- Low fat diet, High fat diet, MCT diet
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity
Factors Affecting Caloric Regulation in Human Feeding
This study will test the hypothesis that reducing the energy density of the diet by incorporating more water-rich foods will result in: 1) greater weight loss and weight maintenance; 2) greater diet satisfaction and satiety; and…
- Trial name
- NCT00108784
- Testing
- Reduced-energy-density diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Glycogen Depletion, Insulin Sensitivity
How is Glycogen Supercompensation Regulated in Human Skeletal Muscle
Nine healthy, moderately fit male volunteers participated in the study. The subjects gave written informed consent after having been informed of any possible risk and discomfort associated with the study.
- Trial name
- Supercomp (NCT03458741)
- Testing
- Glycogen Supercompensation
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetic Cardiomyopathies, Type2 Diabetes
Effect of High-intensity Interval Training on Cardiac Function and Regulation of Glycemic Control in Diabetic Cardiomyopathy
According to data of the International Diabetes Federation (IDF), diabetes in general affects approximately 415 million people worldwide and this number is still increasing.
- Trial name
- NCT03299790
- Testing
- high-intensity interval exercise training (HIIT), moderate-intensity exercise training (MIT)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University