Clinical trials: Metabolites
Dietary Modifications
Absorption and Metabolism of Dietary Phenolics From Raspberries
Red raspberries are a rich source of (poly)phenolic compounds, the main components being anthocyanins and ellagitannins. There is growing evidence linking consumption of these compounds with beneficial effects on human health.
- Trial name
- NCT02520596
- Testing
- Bioavailability of Raspberry polyphenols
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Parma
Healthy
Multiple-Ascending-Dose Study to Evaluate the Safety of Propoxyphene Napsylate In Healthy Adult Subjects
The purpose of this study is to determine the daily maximum tolerated dose of propoxyphene napsylate in healthy subjects.
- Trial name
- NCT01133873
- Testing
- Propoxyphene napsylate (XP20C)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Xanodyne Pharmaceuticals
Cervical Cancer
The Mechanism of Vaginal Flora and Its Metabolites in the Pathogenesis of Cervical Cancer
The disorder of vaginal microflora and its metabolites is considered to be a facilitating factor to human papillomavirus-mediated cervical cancer. However, the mechanism is still unclear.
- Trial name
- NCT05185713
- Testing
- This project is a clinical observational study. No additional medication or surgical interventions are performed on the subjects.
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dietary Exposure, Metabolic Disturbance
Influence of Tart Cherry Juice Intervention on Vascular Function
Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results.
- Trial name
- NCT04840160
- Testing
- Cherry juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy Volunteers
Measuring Effects of Alcohol on Brain Chemistry
Background: Studies show that alcohol changes the amount of many brain chemicals. These changes may be related to continued drinking, craving for alcohol, and relapse.
- Trial name
- NCT01492933
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Endometrial Carcinoma
Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain
This phase IV trial studies whether low dose aspirin can be used to lower inflammation and prevent endometrial cancer in postmenopausal women with changes in the endometrial tissue that are not related to thinning (non-atrophic…
- Trial name
- NCT07281547
- Testing
- Biospecimen Collection, Low-Dose Aspirin, Patient Observation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Changes in Microbiome and Metabolites Regarding Physical Activity in Middle-aged Korean Women
This study aimed to examine the effect of physical activity (PA) on health through changes in multi-omics biomarkers during 6 months of exercise intervention.
- Trial name
- NCT05927675
- Testing
- Physical activity
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Liver Cancer, Liver Cirrhosis
A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Liver Cancer
The incidence of liver cancer in China shows a clear clinical path of hepatitis/fatty liver liver cirrhosis liver cancer. The dynamic changes of the internal environment on this pathway are important clues for early detection…
- Conditions
- Liver Cancer, Liver Cirrhosis, Fatty Liver, Hepatitis
- Trial name
- NCT05719480
- Testing
- Proteomics technology and liquid biopsy
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Parkinson Disease
Absorption, Distribution, Metabolism and Excretion of [14C]-Labeled BIA 9-1067 and Metabolites
To determine the absorption, metabolism and excretion of BIA 9-1067.
- Trial name
- NCT01515891
- Testing
- BIA 9-1067
- Where
- Switzerland
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Alzheimer's Disease
Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
Rilapladib is a potent and selective inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), which was previously under development for the treatment of atherosclerosis and is currently being developed for the treatment…
- Trial name
- NCT02130661
- Testing
- Rilapladib 25 mg, Rilapladib 250 mg, Itraconazole
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postprandial Inflammation
Absorption and Digestion Kinetics of Human Metabolites
The purpose of this pilot study is to evaluate the effects oral supplementation with four human metabolites (spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide(OEA)) at varying doses on the circulating…
- Trial name
- NCT05017428
- Testing
- Spermidine, Nicotinamide, PEA
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Inborn Errors of Metabolism, Epilepsy (Treatment Refractory)
Metabolites in Blood and Breath in Metabolic Conditions
In patients with inborn errors of metabolism (IEM) and in those requiring a ketogenic diet for the treatment of medical conditions, relevant biochemical analytes are routinely and regularly measured in venous or capillary blood…
- Trial name
- NCT07704606
- Testing
- Observational Study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Healthy
Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants
This study will evaluate the absolute bioavailability of CORT118335 and determine the mass balance recovery, absorption, metabolism and elimination, and metabolite profile and identification of metabolite structures following a…
- Trial name
- NCT03878264
- Testing
- CORT118335 Oral, 14C-CORT118335 intravenous, 14C-CORT118335 oral
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Inflammatory Bowel Disease, Crohn's Disease
The Impact of 6MP Metabolite Levels on Infliximab Pharmacokinetics and Anti-infliximab Antibodies in Crohn's Disease
In this research proposal, the investigators will focus on methods to optimize the therapeutic response to anti-TNF antibodies, by determining a correlation of 6-mp metabolite levels with IFX trough levels, anti-IFX antibody…
- Trial name
- NCT02453607
- Testing
- Infliximab, thiopurine
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Ernest Seidman
Probiotics, Oral Health
Double-blind Clinical Trials of Probiotic Products in Oral Health.
In order to evaluate the effects of supplementary probiotics and their metabolites on oral environment and oral microbiota, Taiwan FDA No.
- Conditions
- Probiotics, Oral Health, Probiotic Metabolites
- Trial name
- NCT04289337
- Testing
- Combined probiotics (1), Combined probiotics (2), Combined heat-killed probiotics (1)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Glac Biotech Co., Ltd
Cognitive Decline, Cognitive Dysfunction
Polyphenols and Cognitive Decline
Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD).
- Trial name
- MAEVE (NCT06507254)
- Testing
- Polyphenol Supplement
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Crossover Drug-Drug Interaction Study to Determine Effects of Cytochrome P450 3A on Exposure to Mifepristone and Its Metabolites
This is a Phase 1, single center, fixed sequence, open label, drug-drug interaction study of the effect of multiple doses of rifampin 600 mg daily, a strong CYP3A inducer, on the exposure of mifepristone at 2 dose levels.
- Trial name
- NCT03258372
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Gastrointestinal Dysfunction, Metabolic Disturbance
Hemp Fiber Ingestion and Gut Permeability After Exercise
Two bioactive compounds, N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT), have been investigated for potential gut health benefits. The shells of hemp seeds are a rich source of NCT and NFT.
- Trial name
- NCT06204666
- Testing
- High Dose Hemp Fiber Bar, Low Dose Hemp Fiber Bar
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Small Cell Lung Cancer
Proteomics in Small Cell Lung Cancer
The aim of this study is to gather insight into tumor-derived circulating extracellular vesicles-proteins in patients with newly diagnosed small cell lung cancer.
- Trial name
- SCLC-OMICS (NCT05623956)
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Healthy
Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants
The purpose of this study was to assess the effect of multiple doses of carbamazepine on single- dose tepotinib pharmacokinetics in healthy participants.
- Trial name
- NCT05213481
- Testing
- Tepotinib, Carbamazepine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany