Clinical trials: Metabolomics
Gut Microbiota Diversity and Composition, Gut Microbiota Modulation
Effects of Barley and Kefir on Gut Microbiota in Physically Active Adults
The purpose of this randomized controlled clinical trial is to investigate whether a four-week dietary intervention consisting of a daily meal with barley and kefir can influence gut microbiota diversity and composition in…
- Conditions
- Gut Microbiota Diversity and Composition, Gut Microbiota Modulation, Probiotic, Prebiotic
- Trial name
- GUTS (NCT07864779)
- Testing
- Barley, Kefir
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Protein Absorption and Amino Acid Availability, Metabolomics
Measurement of Acute Metabolite Changes Following Consumption of Microalgae Drinks
Protein consumption is essential for various physiological processes, with microalgae and plant proteins gaining increasing attention due to their health benefits.
- Trial name
- NCT07791420
- Testing
- Bead-milled microalgae, Non-bead-milled microalgae, Whey protein isolate
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Microbiome Analysis, Metabolomics
Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites
The objective of this study is to determine whether inter-individual differences in the gut microbiome influence exposure to blueberry polyphenol metabolites.
- Trial name
- BlueBIOME (NCT07607158)
- Testing
- Freeze-dried blueberry powder beverage
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Body Weight, Obesity & Overweight
Breastmilk and the Link to Overweight/Obesity and Maternal Diet in the Mother-breastmilk-child Triad
The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity).
- Conditions
- Body Weight, Obesity & Overweight, Human Milk/Breastfeeding, Body Composition
- Trial name
- BLOOM-Triad (NCT07457515)
- Where
- 4 sites in Canada, Poland
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Warsaw University of Life Sciences
Caries, Metabolomic Profile
Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries
Saliva insulin shows promise as a non-invasive biomarker of high carbohydrate intake and/or insulin resistance, key risk factors for metabolic dysregulation and caries.
- Trial name
- NCT05211843
- Testing
- Drinking water, Apple juice
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Jodi Stookey
Obesity & Overweight, Hair Loss
Scalp Hair Metabolomics in Severe Obesity
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time.
- Conditions
- Obesity & Overweight, Hair Loss, Metabolomics, Bariatric Surgery
- Trial name
- NCT07368842
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Ureteral Stricture, Ureteral Obstruction
An Integrated Multi-omics Study on the Molecular Mechanisms of Ureteral Stricture
The goal of this observational study is to investigate the systemic pathogenesis and identify potential diagnostic biomarkers in patients with ureteral stricture and healthy volunteers.
- Conditions
- Ureteral Stricture, Ureteral Obstruction, Microbiome, Metabolomics
- Trial name
- US-MOP (NCT07409870)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Obesity, Brain Function
Food Intake-Related Brain and Metabolic Responses in Obesity
This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled.
- Conditions
- Obesity, Brain Function, Metabolomics, Feeding Behavior
- Trial name
- NCT07392905
- Testing
- Glucose Liquid Meal, Fat Liquid Meal, Protein Liquid Meal
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis
Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With ARDS
This study is a prospective observational investigation designed to systematically characterize key microbial signatures, metabolite profiles, and gene-expression features in serum and sputum from patients with acute respiratory…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis, Multiomics Analysis, Metabolomics
- Trial name
- NCT07380997
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Epilepsy, Microbiota
EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE
The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work.
- Conditions
- Epilepsy, Microbiota, Proteomics, Metabolomics
- Trial name
- EpiGUT (NCT07253701)
- Where
- 6 sites in Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
The Impact of American Ginseng on the Metabolomics of Urine and Plasma in Healthy Individuals
LCMS-Based Metabolic Analysis Explores the Effect of American Ginseng on Urine and Plasma in Healthy Individuals
Researchers will use LCMS Metabolic Analysis to Explore the Effect of American Ginseng on Urine and Plasma in Healthy Individuals Participants will: Take 3 grams of American Ginseng powder every day for 14 days Collect the…
- Trial name
- NCT07252362
- Testing
- American Gginseng
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Biological Markers, Diet, Healthy
Dietary Biomarkers Intervention Core
The purpose of this controlled feeding trial is to establish an Intervention Core, equipped to perform tightly controlled pharmacokinetic (PK) and dose-response (DR) feeding studies.
- Conditions
- Biological Markers, Diet, Healthy, Metabolomics, Nutrition, Healthy
- Trial name
- NCT05616585
- Testing
- Pharmacokinetic (PK)- Controlled Feeding Diet, Dose Response (DR)- Controlled Feeding Diet
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Lactate, Sports Performance
Association Between Training Load and Lactate and Other Metabolites Analyzed by Metabolomic and Proteomic Techniques
Physical exercise induces numerous changes in the body in a complex signalling network caused by or in response to increased metabolic activity of contracting skeletal muscles.
- Conditions
- Lactate, Sports Performance, Metabolomics, Proteomics
- Trial name
- PROTEOMET (NCT06365320)
- Testing
- Single basketball training
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Premature Ovarian Insufficiency, Metabolomics
Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics
1. Identify differential metabolites in POI patients. 2. Analysis of differential metabolites and their involved mechanism pathways.
- Conditions
- Premature Ovarian Insufficiency, Metabolomics, Traditional Chinese Medicine, Mechanism
- Trial name
- JJGS and POI (NCT06102655)
- Testing
- Jiajian Guishen Formulation
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile
Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities
The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1)…
- Conditions
- Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile, Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities
- Trial name
- 3X (NCT05365334)
- Testing
- Low intensity exercise session, Moderate intensity exercise session, High intensity exercise session
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Metabolomics; Retinopathy; Etiology
Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was…
- Trial name
- NCT06408571
- Testing
- etiology
- Where
- China
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Adiposity, Insulin Resistance
PREterM FOrmula Or Donor Breast Milk for Premature Babies
In order to address this crucial question, central to preterm newborn care, a multicentre United Kingdom (UK) -wide study randomising 4000 preterm babies would be necessary to achieve sufficient power to evaluate the impact on…
- Conditions
- Adiposity, Insulin Resistance, Metabolomic Profile, microRNA Profile
- Trial name
- PREMFOOD (NCT01686477)
- Testing
- Unfortified Human donor Milk used to make up any shortfall in mother's own milk, Fortified Human donor Milk used to make up any shortfall in mother's own milk, Preterm Formula used when there is a shortfall in mother's own milk
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Methylphenidate, Metabolomics
Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD
To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children…
- Trial name
- NCT06073470
- Testing
- methylphenidate
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Microbial Disease, Metabolomics
Foot-skin Microbiome and Metabolomics of Pitted Keratolysis
This study aimed to investigate the skin microbiome and metabolomics of patients with pitted keratolysis.
- Trial name
- Foot-skin M&M (NCT04781036)
- Testing
- 4%Chlorhexidine
- Where
- 2 sites in Thailand
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mahidol University