Clinical trials: Metastasis to Vertebral Column
Spinal Metastases, Spinal Tumor
En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.
The purpose of this clinical trial is to explore the impact of En bloc surgery and separation surgery combined with radiation therapy on the prognosis and survival of patients with spinal oligometastatic cancer, describe the…
- Conditions
- Spinal Metastases, Spinal Tumor, Radiotherapy, Malignant Bone Tumor
- Trial name
- NCT06120426
- Testing
- total en bloc spondylectomy
- Where
- China
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Spinal Metastases, Surgery
CT-DSA Evaluation of Embolization in Debulking Spinal Surgery
Vertebra is one of the most common site of metastatic disease, which may cause severe pain or neurological deficit. Decompressive surgery or radiation therapy are of limited efficacy and recurrence is very likely.
- Trial name
- NCT04497051
- Testing
- CT-DSA
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Bone Lesion, Bone Metastases
Ablation and Cementoplasty for Painful Bone Lesions
The aim of this research study is to assess the effectiveness of combined ablation and cementoplasty in the treatment of spinal, pelvic, and extraspinal lesions causing pain resistant to conventional treatment at our centre.
- Conditions
- Bone Lesion, Bone Metastases, Spine Metastases
- Trial name
- NCT04635137
- Testing
- Ablation and Cementoplasty
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Spinal Metastases, Blood Transfusion Complication
The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases.
- Conditions
- Spinal Metastases, Blood Transfusion Complication, Lung Cancer, Surgery
- Trial name
- NCT06244264
- Testing
- Autoblood transfusion
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Guangdong Provincial People's Hospital
Spinal Metastases
Conventional With Stereotactic Radiotherapy for Pain Reduction and Quality of Life in Spinal Metastases
A randomized, multicentre, phase III study comparing conventional radiotherapy (1x8Gy) with stereotactic radiotherapy (1x20Gy) for pain reduction and quality of life in spinal metastases.
- Trial name
- RACOST (NCT02407795)
- Testing
- conventional radiotherapy, stereotactic radiotherapy
- Where
- 6 sites in Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Spine Metastases, Bone Pain
Radiofrequency Ablation/Bone Augmentation + Radiotherapy vs Radiotherapy Alone
This is a single-center, randomized controlled pilot study of radiofrequency ablation and bone augmentation (RFA/BA) plus radiotherapy (RT) vs. RT alone in patients with metastatic T5-L5 disease of the spine.
- Trial name
- NCT07090122
- Testing
- Radiofrequency ablation and bone augmentation with radiotherapy, Radiotherapy alone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Spinal Metastases
Stereotactic Body Radiotherapy (SBRT) for Spinal/Para-Spinal Metastases (Spine SBRT)
Patients with new or recurrent spine metastases are currently treated with low doses of radiation delivered in up to ten treatments (wide-field radiation therapy).
- Trial name
- NCT01290562
- Testing
- Stereotactic Body Radiotherapy (SBRT)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Spinal Metastases, Spinal Tumors
SBRT Technique Implementation for Spinal Metastases Irradiation
Stereotactic body radiotherapy (SBRT) is a highly precise, image-guided radiotherapy technique delivering 1-5 high-dose fractions to spinal metastases.
- Conditions
- Spinal Metastases, Spinal Tumors, Bone Metastases
- Trial name
- NCT07429422
- Testing
- Stereotactic Body Radiotherapy (SBRT) for Spinal Metastases
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Spinal Cord Compression Due to Metastasis to Spine
RAdiotherapy for Metastatic Spinal Cord Compression with Increased Radiation DosES
This clinical study aims to investigate whether high-precision radiotherapy, as supposed, leads to a better control of the irradiated spinal cord metastases when compared to conventional radiotherapy.
- Trial name
- RAMSES-01 (NCT04043156)
- Testing
- High-precision RT
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- University Hospital Schleswig-Holstein
Spine Metastases, Radiation Therapy
Increased Early Pain Relief by Adding Vertebroplasty to SBRT
The goal of treating metastases is to preserve stability and neurological function while reducing pain. The actual standard of care is stereotaxic body radiation therapy (SBRT) alone in non-surgical patients.
- Conditions
- Spine Metastases, Radiation Therapy, Pain
- Trial name
- NCT05317026
- Testing
- Vertebroplasty, Stereotactic Body Radiation Therapy only
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Spinal Metastases
Efficacy of Dose Intensified Radiotherapy of Spinal Metastases by Hypofractionated Radiation and IGRT hfSRT Mediated Boost
Spinal metastases indicate for an incurable course of disease. Local tumor control after palliative radiotherapy of spinal metastases (10x3 Gy, 1x8Gy) is between 61 to 81%.
- Trial name
- SPIN-MET (NCT01849510)
- Testing
- hypofractionated 12x3 Gy + integrated boost 12x4 Gy, hypofractionated 10x3 Gy
- Where
- 3 sites in Germany
- Volunteers
- 155 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Vertebral Bony Metastases
Image-guided and Intensity-modulated Radiotherapy Versus External Beam Radiotherapy for Patients With Spine Metastases
The aim of this explorative trial is to verify the comparability of a fractionated intensity modulated radiotherapy with a conventional radiotherapy related to quality of life on the one hand and to evaluate toxicity…
- Trial name
- IRON-1 (NCT02832830)
- Testing
- IMRT, fractionated RT
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Spine Metastases
Posterior Corpectomy in Thoracolumbar Spinal Metastatsis
To analyze the short-term outcomes of posterior corpectomy of patients with thoracolumbar spinal metastasis in spine unit in Assiut University hospital regarding the pain control , neurological status , complication and…
- Trial name
- NCT06117475
- Testing
- Posterior corpectomy
- Volunteers
- 30 people
- Sponsor
- Assiut University
Spinal Metastases
Kypho-Intra Operative Radiation Therapy (IORT) for Localized Spine Metastasis, Phase I/II Study
Kypho-IORT is a novel approach to combine kyphoplasty, a minimally invasive procedure, with a single dose of intraoperative radiotherapy (IORT) for the treatment of unstable or potentially unstable spinal cord metastases.
- Trial name
- Kypho-IORT (NCT02987153)
- Testing
- Kypho-IORT
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Northwell Health
Spine Metastasis
Spinal met_radiosurgery/SBRT Study
Demonstrate the technical feasibility of treating spine metastases with image-guided radiosurgery/SBRT
- Trial name
- NCT01231061
- Testing
- SBRT, Radiosurgery
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- Chinese University of Hong Kong
Cancer, Metastases
Analysis of Tokuhashi Score
70% of all cancer patients develop some form of visceral (internal organs) or skeletal metastases (spread of disease). Approximately one third of cancer patients develop metastases to the spinal column.
- Trial name
- NCT01210508
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- State University of New York - Upstate Medical University
Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization for Patients With Unstable Spinal Metastases
The aim of this study is to assess the feasibility and safety of combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic…
- Trial name
- BLEND (NCT02622841)
- Testing
- BLEND
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- UMC Utrecht
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Spinal Metastases
Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery
The investigators wish to evaluate the effect of minimal access spinal surgery compared to traditional open surgery spinal surgery in patients with metastatic spinal cord compression.
- Trial name
- NCT01865942
- Testing
- open surgery, Minimal access surgery
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Metastases
Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
The purpose of this study is to determine if quantitative magnetic resonance imaging (qMRI) can objectively measure changes in the tumor/vertebral body and adjacent spinal cord following stereotactic body radiation therapy (SBRT)…
- Trial name
- NCT04248543
- Testing
- qMRI with Gadoteridol contrast agent
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University