Clinical trials: Metastatic Spine Tumor
Melanoma, Metastatic Malignant Neoplasm in the Spine
Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery
This pilot clinical trial studies adaptive staged stereotactic body radiation therapy (SBRT) in treating patients with spinal metastases that cannot be removed by surgery.
- Conditions
- Melanoma, Metastatic Malignant Neoplasm in the Spine, Renal Cell Carcinoma, Soft Tissue Sarcoma
- Trial name
- NCT02527304
- Testing
- Image-Guided Adaptive Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Albert Einstein College of Medicine
Spinal Metastases
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS.
- Trial name
- NCT06173401
- Testing
- Single-fraction spine SRS, Multi-fraction spine SRS
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Stanford University
Cancer Metastatic
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
This study is being done to answer the following question: Is Stereotactic Body Radiation Therapy or SBRT (a form of radiation therapy which can deliver high doses of radiation to the specific painful area of the body most…
- Trial name
- NCT06391242
- Testing
- Standard Conventional Radiotherapy, Stereotactic Body Radiotherapy
- Where
- 12 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Canadian Cancer Trials Group
Metastatic Spine Tumor
Metastatic Tumor Research and Outcomes Network
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with…
- Trial name
- MTRON (NCT02830451)
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 2,417 people
- Sponsor
- AO Innovation Translation Center
Adult Spinal Cord Neoplasm, Spinal Bone Metastases
Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
This pilot clinical trial studies beta-tricalcium phosphate bone graft in treating patients undergoing surgery for metastatic spine cancer.
- Conditions
- Adult Spinal Cord Neoplasm, Spinal Bone Metastases, Spinal Cord Compression
- Trial name
- NCT01407341
- Testing
- musculoskeletal complications management/prevention, bone graft, quality-of-life assessment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Metastatic Cancer
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates
Stereotactic ablative body radiotherapy (SABR) can be considered for patients with so-called "oligometastatic" disease. However, since this is a relatively new technique, information on the optimal scheduling is lacking.
- Trial name
- Destroy (NCT03486431)
- Testing
- Stereotactic Ablative Radiotherapy (SABR)
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Cancer Research Antwerp
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Primary Tumor, Metastatic Cancer
Randomized Study of Stereotactic Body Radiotherapy vs. Conventional Radiation for Spine Metastasis
The purpose of this study is to determine how effective SBRT is compared to traditional radiation in treating the cancer that has spread to your spine and is causing pain.
- Trial name
- NCT01525745
- Testing
- Radiosurgery/SBRT, External Beam Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Spinal Metastasis
Combining Intraoperative Radiotherapy With Kyphoplasty for Treatment of Spinal Metastases
The primary objective is to evaluate the tolerability (side effects) of the intraoperative radio therapy (IORT) (e.g., wound healing, infections, bone necrosis, nerve, spinal cord damage, and pathological fracture), and the…
- Trial name
- KYPHO-IORT (NCT02480036)
- Testing
- IORT with Kyphoplasty, Intrabeam®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Loyola University
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley
Metastatic Malignant Neoplasm, Metastatic Malignant Neoplasm in the Bone
18F-FDG PET-MRI for Planning and Follow-Up of Patients With Spine Tumors Treated With Spine Stereotactic Radiosurgery
This trial studies how well 18F-FDG PET-MRI works for treatment planning in patients with spine tumors. Diagnostic procedures, such as 18F-FDG PET-MRI may help radiation oncologists plan the best treatment for spine tumors, as…
- Trial name
- NCT05174026
- Testing
- Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatocellular Carcinoma, Spine Metastasis
Diffusion-Weighted Magnetic Resonance Imaging
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment…
- Trial name
- NCT02242786
- Testing
- External beam radiation therapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Samsung Medical Center
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Spinal Metastasis
RELIEVE: Research on Effectiveness of Surgery and Radiotherapy on Relieving Spine Tumor Pain in Patients with Vertebral Metastases
This is a prospective, multicenter, observational study focusing on assessing and managing pain in patients with metastatic spinal tumors.
- Trial name
- RELIEVE (NCT06746103)
- Testing
- Surgery
- Volunteers
- 250 people
- Sponsor
- AO Foundation, AO Spine
Newly Diagnosed Melanoma Metastases in the Brain and Spine
SRS (Stereotactic Radiosurgery) Plus Ipilimumab
This research is being done to look at the safety of using stereotactic radiosurgery (SRS) and Ipilimumab together to treat melanoma that has spread to the brain or spine.
- Trial name
- NCT01950195
- Testing
- Stereotactic Radiosurgery (SRS), Ipilimumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Metastatic Malignant Neoplasm in the Spine
Medical Data Collection for the Evaluation of Radiofrequency Ablation and Cement Augmentation for the Treatment of Secondary Metastases to the Spine
This study collects data on the use of radiofrequency ablation and cement augmentation for the treatment of cancer that has spread to the spine (metastases to the spine).
- Trial name
- NCT04751422
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Cancer
Stereotactic Radiosurgery in Treating Patients With Spinal Metastases
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. It may also help patients with spinal metastases live more comfortably.
- Trial name
- NCT00853528
- Testing
- questionnaire administration, diffusion tensor imaging, functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Boston Medical Center
Metastatic Cancer, Pain
Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue.
- Conditions
- Metastatic Cancer, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00855803
- Testing
- radiation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Texas Southwestern Medical Center
Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Malignant Neoplasm in the Spine
Standard and Delayed FDG PET/CT After Chemoradiation Therapy in Assessing Patients With Metastatic Head and Neck Squamous Cell Cancer
This trial studies how well standard and delayed fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/computed tomography (CT) given after standard radiation and chemotherapy works in assessing patients with head and…
- Trial name
- NCT03575949
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Osseous Spine Metastases
Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR)
A randomized phase III study of palliative external beam radiotherapy (RTOG 97-14) has shown that 8 Gy in a single fraction is very effective in providing pain relief, with complete or partial improvement in pain seen in 66% of…
- Trial name
- NCT00267033
- Testing
- injection of orthopaedic cement into vertebral bodies
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris