Clinical trials: Methamphetamine Addiction
Drug Addiction
Drug Effects on Preference and Reward
Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans.
- Trial name
- NCT01722006
- Testing
- Pairing condition
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Methamphetamine-dependence
Paired Associative Stimulation in Methamphetamine Addiction
The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.
- Trial name
- NCT03910608
- Testing
- MagPro X100 device (MagVenture, Farum, Denmark)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine-dependence
Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users
Addiction to methamphetamine is a serious health problem in the United States. Right now, there are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- Ibudilast (NCT03341078)
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Methamphetamine Dependence
Comparison of Methamphetamine-Dependent and Healthy Volunteers Using a Web-Enabled Cognitive Neuropsychological Evaluation System
The purpose of this study is to develop the technology infrastructure for a mobile Web-based cognitive and neuropsychological assessment of substance abusers, and to perform a pilot trial using neurocognitive tasks designed to…
- Trial name
- 5I (NCT01919437)
- Testing
- Web-Enabled Cognitive Neuropsychological Evaluation System
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Methamphetamine Dependence, Methamphetamine Abuse
Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)
This is a human inpatient clinical pharmacology study to assess potential interactions between intravenous (i.v.) methamphetamine infusion and oral osmotic release methylphenidate (OROS-MPH).
- Trial name
- NCT00603434
- Testing
- OROS-MPH
- Where
- 2 sites in United States, Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Methamphetamine Dependence
Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study
The study is to primarily measure safety and interactions between oral doses of Naltrexone/Bupropion and i.v. Methamphetamine.
- Trial name
- NCT01359930
- Testing
- Naltrexone and Bupropion SR
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Dependence
Citicoline Treatment of Methamphetamine Dependence
The purpose of the study is to determine if citicoline (a nutritional supplement) is effective in helping people reduce their dependence on methamphetamine.
- Trial name
- NCT00950352
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Methamphetamine-dependence
Glutide for Ending Methamphetamine
GEM is a two-phase study to evaluate the use of semaglutide (Wegovy) for the treatment of methamphetamine use disorder (MeUD). The first phase is a pilot study, which will be an open-label, single-arm pilot study of 25…
- Trial name
- GEM (NCT07204249)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Methamphetamine Abuse, Methamphetamine Dependence
Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse
The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, oxazepam (Serax®) and naltrexone (Revia®), as a pharmacotherapy for methamphetamine (Desoxyn®)…
- Trial name
- NCT01967381
- Testing
- Methamphetamine (Desoxyn®)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Methamphetamine Dependence
Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving
Specific Primary Aims include: Aim # 1. The investigators explore the feasibility of using the TMS to investigate the cortical excitability and to inhibit meth cue craving in meth dependent population.
- Trial name
- NCT01685463
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Methamphetamine Use Disorder
A Study for the Risky Decision-making Deficits Among Methamphetamine Dependence Individuals and Treatment
The risky decision-making deficits is the core feature of the methamphetamine (MA) dependence. Our previous research found that MA dependents have network abnormalities such as decision-making and rewarding.
- Trial name
- NCT06279273
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine-dependence, Rectal Gonorrhea
Inflammation in Methamphetamine and STIs (IMSTI)
This clinical trial aims to investigate the effects of a decline in methamphetamine use on rectal inflammatory cytokine levels, substance use contexts, and HIV/STI risk behavior.
- Conditions
- Methamphetamine-dependence, Rectal Gonorrhea, Rectal Chlamydia
- Trial name
- IMSTI (NCT05162391)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Methamphetamine Dependence
Tolerability and Safety of 30, 45, and 60 mg of Sublingual Lobeline. - 1
The purpose of this study is to assess safety and pharmacokinetics of sublingual lobeline in healthy normal volunteers.
- Trial name
- NCT00519259
- Testing
- Lobeline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine-dependence, HIV-1-infection
Contingency Management for PrEP Adherence and/or Methamphetamine Use
Use of crystal methamphetamine (MA) leads to changes in sexual risk behavior, adherence to HIV prevention tools, immune response to infection, and tissue inflammation that collectively increase risk for HIV transmission among…
- Trial name
- C-MAX (NCT04563962)
- Testing
- Contingency Management-ART, Contingency Management-Methamphetamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Methamphetamine Dependence
Risk and Protective Factors for Rural Methamphetamine Dependence
The primary goal of this study is to identify factors which may put a person that has used methamphetamine at greater risk for mental and physical health problems and social problems and factors that may lessen the risk for these…
- Trial name
- NCT00882037
- Where
- 2 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Methamphetamine Dependence
Ph1 Lobeline Interaction Study - 1
The purpose of this study is to determine if there are significant cardiovascular or other interactions between sublingual lobeline and intravenous methamphetamine.
- Trial name
- NCT00439504
- Testing
- Lobeline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Methamphetamine-dependence
The Effect of Mindfulness-based Relapse Prevention on Impulsive Control Circuit Among Methamphetamine Dependents
Amphetamine-type stimulants (ATSs) have become the most important medical issue as well as the social problem. Compared with traditional drugs, ATS are highly neurotoxin and can induce cognitive deficit and psychotic symptoms.
- Trial name
- NCT03748875
- Testing
- mindfulness-based relapse prevention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Substance-Related Disorders
Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation
Drug addiction is compulsive and spontaneous drug-taking behavior which is characterized by non-medical usage, long and repeated exposure to addictive drugs and gradually increasing drug-taking dosage and frequency,and become a…
- Trial name
- NCT02594306
- Testing
- Emotional pictures stimulation system, Deep brain stimulation, adjacent contact stimulation
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital