Clinical trials: Methamphetamine Disorders
Nasal Congestion
Steady State Kinetics of l-Methamphetamine and Validation of Sensitivity of Dose Estimation
The intent of this study is to see if the rate that the body breaks down l-methamphetamine (l-MA) could be used as an accurate estimate for the rate that the body breaks down d-methamphetamine (d-MA).
- Trial name
- NCT00829634
- Testing
- l-methamphetamine, d-methamphetamine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Caregiver Burden in Methamphetamine Use Disorder, Expressed Emotions in Caregivers
Effectiveness of Stress Management Training Program For Expressed Emotions in Caregivers of Drug Induced Psychosis Patients Specially Methamphetamine
The main purpose of this study is to evaluate the effectiveness of a Stress Management Training (SMT) program in reducing stress levels among caregivers of individuals suffering from methamphetamine ("ice") addiction and…
- Conditions
- Caregiver Burden in Methamphetamine Use Disorder, Expressed Emotions in Caregivers, Stress Cause Expressed Emotion and Burden
- Trial name
- NCT07714642
- Testing
- O'Connor's (2003) Stress Management Training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Amphetamine Use Disorders
Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder
Repetitive transcranial magnetic stimulation (rTMS) was used to treat methamphetamine use disorder in previous studies, while the evidence-based protocols still required.
- Trial name
- NCT03736317
- Testing
- real mPFC cTBS, real dlPFC iTBS, real dlPFC iTBS + real mPFC cTBS
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Stress Physiology, Stress Reaction
The Human Stress Response in a Simulated ED Setting
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respond as they do when they come…
- Conditions
- Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence
- Trial name
- NCT04317482
- Testing
- Standard social stress task, Stressful experience in the ED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Methamphetamine Use Disorder, Methamphetamine Induced Psychosis
ECG Findings in Methamphetamine Use
This prospective cohort study aims to examine and compare electrocardiogram (ECG) parameters in subjects diagnosed with Methamphetamine Use Disorder (MUD) and Methamphetamine-Induced Psychotic Disorder (MP) during inpatient…
- Trial name
- NCT07459244
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Substance-Related Disorders
Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation
Drug addiction is compulsive and spontaneous drug-taking behavior which is characterized by non-medical usage, long and repeated exposure to addictive drugs and gradually increasing drug-taking dosage and frequency,and become a…
- Trial name
- NCT02594306
- Testing
- Emotional pictures stimulation system, Deep brain stimulation, adjacent contact stimulation
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Amphetamine Dependence
Dose Response of Mirtazapine to Methamphetamine Induced Interest, Mood Elevation and Reward
The primary purpose of this study is to determine if Mirtazapine will produce a decrease in interest in the drug, a decrease in mood elevation, and/or a decrease in reward when given before methamphetamine compared to placebo.
- Trial name
- NCT00600145
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
HIV Infections
Reduction of Drug Use and HIV Risk Among Out-of-Treatment Methamphetamine Users
There is a need to identify and test effective strategies to reduce meth use and human immunodeficiency virus (HIV) risk behaviors in heterosexuals.
- Trial name
- NCT01161485
- Testing
- HIV Testing and Counseling, Contingency Management, Strengths-based case management
- Where
- United States
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Substance Abuse, HIV Infections
Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors
Studies demonstrate that methamphetamine (meth) use is associated with high-risk sexual behavior among MSM, putting meth-using MSM at extraordinarily high risk for transmitting or acquiring HIV.
- Trial name
- NCT00497081
- Testing
- mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Methamphetamine Induced Psychosis, Cannabis Use
Psychiatric Symptom Characteristics in Methamphetamine-Induced Psychosis With and Without Lifetime Cannabis Use
This prospective cohort study aims to investigate factors associated with psychiatric symptom severity in participants diagnosed with methamphetamine-induced psychotic disorder (MP) with and without lifetime cannabis use (LCU).
- Trial name
- NCT07459270
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Methamphetamine Use Disorder
A Study for the Risky Decision-making Deficits Among Methamphetamine Dependence Individuals and Treatment
The risky decision-making deficits is the core feature of the methamphetamine (MA) dependence. Our previous research found that MA dependents have network abnormalities such as decision-making and rewarding.
- Trial name
- NCT06279273
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Stimulant Abuse, HIV Prevention
Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the efficacy of Project IMPACT, an intervention that integrates Behavioral Activation (BA) with HIV risk reduction (RR) counseling for…
- Conditions
- Stimulant Abuse, HIV Prevention, Substance Abuse
- Trial name
- NCT03175159
- Testing
- IMPACT, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Substance-Related Disorders, HIV
Expression of Stress Markers During Meth Treatment (EXPRESS+)
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive…
- Trial name
- EXPRESS+ (NCT05558345)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Substance Use Disorders, Methamphetamine Abuse
A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants
The purpose of this Phase 1a study is to evaluate safety, tolerability, and pharmacokinetics (PK) of single, ascending doses of CS-1103, administered by intravenous (IV) infusion in healthy participants.
- Conditions
- Substance Use Disorders, Methamphetamine Abuse, Methamphetamine Intoxication
- Trial name
- NCT06316973
- Testing
- CS-1103, Sterile Saline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Substance-Related Disorders
DOX as a Potential Treatment for Methamphetamine Dependence
The purpose of the study is to asses the potential interactions between methamphetamine and doxazosin in methamphetamine-dependent volunteers who are not seeking treatment.
- Trial name
- DOX-Meth (NCT02785393)
- Testing
- Sugar Pill, Doxazosin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Methamphetamine Use Disorder
Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM
This is a double-blind, placebo-controlled phase 2b trial in which 54 MSM who use meth will be randomly assigned (2:1) to receive 12 weeks of as-needed intermittent oral naltrexone 50 mg enhanced with an EMA-informed EMI…
- Trial name
- NCT04791969
- Testing
- Naltrexone Hydrochloride, Ecological Momentary Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Glenn-Milo Santos
Substance-Related Disorders
Rivastigmine For Methamphetamine Dependent Individuals
Methamphetamine abuse has been steadily increasing over the past decade. Rivastigmine is a medication that may be helpful in treating methamphetamine dependence.
- Trial name
- NCT00158210
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)