Clinical trials: MicroRNAs
Inflammatory Bowel Diseases
Identify Specific Peripheral Blood Mononuclear Cell (PBMC) MiRNA as Biomarkers for Inflammatory Bowel Disease (IBD)
To find high sensitivity and specificity biomarkers to better diagnose and monitor progression of inflammatory bowel disease (IBD).
- Trial name
- NCT04256538
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoporosis
Roles of microRNAs in the Development of Osteoporosis in Men - Preliminary Study
This study is aimed to evaluate the roles of specific miRNAs in osteoporosis in men.
- Trial name
- NCT02705040
- Testing
- Normal, Osteopenia, Osteoporosis
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Pre-Eclampsia
Diagnostic Value of MicroRNA 210 In Preeclampsia
Pre-eclampsia is a disorder of pregnancy characterized by hypertension (defined as systolic blood pressure 140mmHg or diastolic blood pressure ⩾90 mmHg) and proteinuria (300 mg or greater in a 24 h urine specimen and/or protein…
- Trial name
- NCT03193554
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnant Women
microRNA Profile in Umbilical Cord Blood NK Cells
Umbilical cords contain immature blood cells, including a group of lymphocytes, that are important in the so-called natural immunity.
- Trial name
- NCT00751569
- Testing
- blood donation
- Where
- Taiwan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnea, Hypertension
Molecular Profile of Cardiovascular Risk in Obstructive Sleep Apnea Patients: Personalized Predictive Model.
Evaluation of anthropometric, clinical and biological profile in four groups that represents transversely the natural history of Obstructive Sleep Apnea (OSA) and its associated cardiovascular comorbidities: non-OSA, OSA without…
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases
- Trial name
- NCT03513926
- Testing
- Continuous Positive Airway Pressure
- Where
- Spain
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Muscular Dystrophies, Becker Muscular Dystrophy
Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies
Duchenne muscular dystrophy (DMD) , caused by mutations in the DMD gene, is the most common and most severe progressive dystrophy of the child.
- Conditions
- Muscular Dystrophies, Becker Muscular Dystrophy, Duchenne Muscular Dystrophy
- Trial name
- biodystromirs (NCT02109692)
- Testing
- blood sample
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pancreas Adenocarcinoma, MicroRNA
The Application of DNA Nanomachines for Detecting microRNA in Blood for the Diagnosis of Pancreatic Cancer. Diagnosis of Pancreatic Cancer
Previous research has shown that microRNAs in the blood can serve as biomarkers for early pancreatic cancer, with potential applications including detection, differential diagnosis, and prognosis prediction of pancreatic cancer.
- Trial name
- NCT06497777
- Testing
- MicroRNA (mir-642b-3p)
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Coronary Syndrome
Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
- Trial name
- NCT02755207
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Autism Spectrum Disorder
Exosomal MicroRNA Expression in Children With Autism Spectrum Disorder
There is accumulating evidence that genetic expression plays a role in autism spectrum disorder, but the regulation of such genes is poorly understood.
- Trial name
- NCT01749670
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Obesity, Morbid, Metabolic Syndrome
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Variable outcomes after weight loss surgery are likely attributable to complex, poorly understood mechanisms. Due to the significant impact that morbid obesity has on a patient's health, successful management of obesity and its…
- Conditions
- Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT04841057
- Testing
- 50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
FNA, microRNA
microRNA in Thyroid Cancer
Thyroid cancer is the most common endocrine malignancy and its incidence is rapidly increasing. Palpable thyroid nodules are very common, affecting up to 5% of the general population.
- Conditions
- FNA, microRNA, Thyroid Cancer, Thyroid Nodule
- Trial name
- NCT01964508
- Testing
- Fine needle aspiration
- Where
- Israel
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Inflammation
MicroRNA Regulation of Chronic Inflammation During Aging
This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age.
- Trial name
- NCT05392582
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Periodontal Diseases Inflammation
Micro Ribonucleic Acid (miRNA) Expression and Inflammatory Factors in Patients With Parkinson's and Periodontal Disease
MicroRNAs are important regulators of the immune and inflammatory response to bacterial pathogens during periodontal disease.The aim of this study was to evaluate the possible miRNA type for Parkinson's in saliva of orally…
- Trial name
- NCT07099378
- Testing
- Saliva and Serum
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medipol University
Breast Cancer Female, Breast Cancer
Oncoliq: Early Breast Cancer Detection Based on Liquid Biopsies and microRNAs
Oncoliq is a novel early breast cancer detection test based on liquid biopsies and microRNAs. This innovative test aims to improve the accuracy of cancer detection, thereby reducing patient mortality and healthcare costs.
- Conditions
- Breast Cancer Female, Breast Cancer, Breast Carcinoma
- Trial name
- NCT06439940
- Testing
- Blood sample extraction
- Where
- Argentina
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Oncoliq US Inc
Relapsing-remitting Multiple Sclerosis
Immune- and miRNA-response to Recombinant Interferon Beta in Healthy Volunteers and Patients With Relapsing Remitting Multiple Sclerosis
There are two standard and a few second line treatments for RRMS. Since the disease cannot be cured by these existing treatments and all treatment options have significant limitations, there is the need to develop new treatment…
- Trial name
- RESI (NCT02364986)
- Testing
- Rebif®, Avonex
- Where
- 2 sites in Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PD Dr. Marcus Müller
Primary Immune Thrombocytopenia
Plasma microRNA Levels and Some Cytokines Expression in Patients With ITP Primary Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts with or without mucocutaneous bleeding (McMillan, 2007).
- Trial name
- microRNAITP (NCT05371743)
- Testing
- Plasma RNA isolation, qPCR analysis of micro RNA, estimation of serum level of IL2, estimation of serum level of IL17
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sohag University
Bipolar Disorder, Frontotemporal Dementia, Behavioral Variant
A Study of the Behavioral Variant of Frontotemporal Dementia and Bipolar Disorder: a Neuroimaging and Epigenetics Integrated Approach
The aim of this study is to investigate the selective epigenetic modifications and their effect on brain's morphology and functionality in the frontotemporal dementia behavioral variant and bipolar disorder.
- Trial name
- DISBAND (NCT06706687)
- Testing
- DISBAND protocol
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Aortic Aneurysm
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"
The objective of this study is to establish whether patients with aortic aneurysm, compared to general population, have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in…
- Trial name
- NCT03090763
- Testing
- PCR and sequencing
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic