Clinical trials: MicroRNAs
Food Addiction, Sexual Addiction
Physiopathology of Behavioral Addictions and Biomarkers
The goal of this observational study is to evaluate the expression of miR-10a-5p in the blood in patients with sexual addiction or food addiction.
- Trial name
- MiRACle (NCT07830680)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
microRNAs in Attention-deficit/Hyperactivity Disorder
Epigenetics in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders in children and adolescents. ADHD's nosology is largely based on clinical phenomenology that includes such symptoms as inattention…
- Trial name
- NCT04860024
- Where
- Taiwan
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Esophageal Cancer
The Utility of Circulating Tumour Cells and Plasma microRNA in Esophageal Adenocarcinoma
Circulating microRNA (circ miRNA) and circulating tumor cell (CTC) levels are hypothesized to be associated with response to chemoradiation in patients undergoing treatment for locally advanced esophageal adenocarcinoma.
- Trial name
- NCT02812680
- Testing
- Blood Draw
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Alzheimer Disease
The Mechanism of MicroRNAs Network in Alzheimer's Disease
MicroRNAs network, such as MicRNA107 et al, regulate the pathology of Alzheimer's disease and the clinical validation in diagnosis AD.
- Trial name
- MicroRNAs AD (NCT05055310)
- Testing
- MicRNAs test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Sepsis
Circulating microRNAs as Biomarkers of Sepsis
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases.
- Trial name
- NCT00862290
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Gastric Cancer, MicroRNAs
MicroRNAs From Blood Samples as Biomarkers for Gastric Cancer Detection
The goal of this observational study is to compare specific microRNA levels from the plasma of gastric cancer patients and healthy volunteers to see if there is an upregulated expression in gastric cancer patients.
- Trial name
- NCT05901376
- Testing
- MicroRNA
- Where
- Thailand
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Lymphoma, B-Cell, Follicular Lymphoma
Identification of Hematological Malignancies and Therapy Predication Using microRNAs as a Diagnostic Tool
MiRNAs are small (~19-25 nucleotides) non-coding RNA molecules that bind to mRNA in a sequence-specific manner. MiRNAs regulate gene expression at the post-transcriptional level.
- Conditions
- Lymphoma, B-Cell, Follicular Lymphoma, Hodgkin Lymphoma, Multiple Myeloma
- Trial name
- NCT02791217
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Non-Viable Pregnancy
Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy
Ectopic pregnancy (EP) is a pathology that affects 3%-16% of pregnancies in humans, being the main cause of morbidity and maternal mortality in the first trimester of pregnancy worldwide.
- Trial name
- TESTKM (NCT03877939)
- Testing
- Blood samples collection for analysis
- Where
- 2 sites in Spain
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Pancreatic Cancer, Adult, Hereditary Pancreatic Cancer
PREVENPANC Project: a Spanish Multicenter Study for Pancreatic Cancer Prevention
Background: Pancreatic cancer (PC) is an aggressive cancer with only a 7% 5-year survival rate, primarily due to late-stage diagnosis.
- Conditions
- Pancreatic Cancer, Adult, Hereditary Pancreatic Cancer, Familial Pancreatic Cancer
- Trial name
- PREVENPANC (NCT06760741)
- Testing
- Multigene panel, Other, miRNA measurement in blood
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Type1diabetes
The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients
Type I Diabetes Mellitus (TIDM) is a chronic metabolic disorder caused by the immune-mediated T-cell and macrophages that typically affects insulin-producing β-cells of Langerhans leading to cell destruction and absolute insulin…
- Trial name
- NCT05874323
- Testing
- Detection of RAGE gene polymorphism (rs1800625)
- Where
- Egypt
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation
HCMV-miRNA Monitoring After Allogeneic Hematopoietic Stem Cell Transplantation Using PSTM-qPCR
Human cytomegalovirus (HCMV) infection is one of the most common and serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Conditions
- Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation, Virus Reactivation, Graft vs Host Disease
- Trial name
- HSCT-HCMV01 (NCT07210242)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ting YANG
Postoperative Delirium
Study of Postoperative Delirium in Elderly People After Orthopedic Surgery
The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.
- Trial name
- NCT02817386
- Testing
- interview
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Breast Cancer
"Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients"
The role of epigenetic regulators and their dysregulation in cancer have gained much attention recently, as they influence the gene expression of many oncogenes and tumor suppressor genes.
- Trial name
- NCT06759714
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
COVID, Conjunctivitis
A Study to Assess the Virus RNA, and miRNA Levels Related to Viral Infection, and Inflammatory Response in Tears of Patients Affected by COVID-19 Disease
The aim of this study is to assess the virus RNA, and miRNA levels related to viral infection, and inflammatory response in tears of hospitalized patients with a diagnosis of COVID-19 with and without conjunctivitis and to…
- Trial name
- NCT04346160
- Testing
- Schirmer Test I
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Drug-induced Liver Injury
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA)
The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or…
- Trial name
- NCT02061826
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Ditan Hospital
Brain Injuries, Traumatic
The Clinical Relevance of Micro RNAs in Mild Traumatic Brain Injury
The aim of this study is to investigate the early serum measurement (<6h after injury) of mRNA miR Let-7i, miR-16 and miR-92 in patients with MHI and intracranial traumatic lesions (CCT pos.) as compared to those in patients with…
- Trial name
- mRNA (NCT02639923)
- Testing
- Drawing of 7ml peripheral blood
- Where
- Austria
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Harald Wolf, MD
Sleepiness, Fatigue
Integral Physiological Adaptations to Carbohydrate Periodization
The purpose of this study is to examine the effect of long-term carbohydrate periodization protocols on sleep architecture, sleep quality, daytime sleepiness, physical performance, body composition, gut microbiome, and miRNA in…
- Conditions
- Sleepiness, Fatigue, Feeding Patterns, Daytime Sleepiness, Excessive
- Trial name
- IPACP (NCT05464342)
- Testing
- Evening LGI Carbohydrate Consumption Group, Evening HGI Carbohydrate Consumption, Evening NO-CHO Carbohydrate Consumption
- Where
- 2 sites in Cyprus, Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Schizophrenia Disorder, Schizophreniform Disorder
MicroRNAs as Biomarkers in First Episode Schizophrenia
This study investigates whether tiny molecules called microRNAs (miRNAs), found in special brain-derived "packages" (neural-derived extracellular vesicles, or NDEs) that travel from the brain into the blood, can serve as helpful…
- Conditions
- Schizophrenia Disorder, Schizophreniform Disorder, Schizoaffective Disorder, Psychosis Not Otherwise Specified (NOS)
- Trial name
- MIRFEST (NCT07703670)
- Testing
- Plasma NDE miRNA Sequencing, Whole Genome Sequencing
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Kidney Disease Requiring Hemodialysis, Chronic Kidney Disease
Serum circ_DLGAP4, lncRNA KCNQ1OT1, and Their Targets by Erythropoietin Resistance in Chronic Kidney Disease
Non-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored.
- Trial name
- NCT07037953
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Non-Diabetic Patients, Wound Leg
Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing
Hypothesis: Elevated miR210 in the epidermis (outer layer of skin) of ischemic human wound edge tissue (tissue that has a lack of blood flow to it) is associated with poor healing outcome in a setting of standard clinical care.
- Conditions
- Non-Diabetic Patients, Wound Leg, Chronic Ulcer Leg/Foot
- Trial name
- miR210 (NCT02024243)
- Where
- 3 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Chandan Sen