Clinical trials: MicroRNAs
Healthy
Exploration of microRNA and Metabolomics Biomarkers Predicting Drug Induced Liver Injury in Elderly People
An open-label, one-sequence, multiple administration study for exploration of microRNA and metabolomics biomarkers to predict drug induced liver injury in healthy elderly Korean people.
- Trial name
- NCT02431832
- Testing
- Augmentin tab
- Where
- South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Acute Graft-versus-Host Disease, Allogeneic Stem Cell Transplant
Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease
Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease (GVHD).
- Trial name
- NCT01521039
- Testing
- Blood samples
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Circulating miRNAs as Biomarkers of Hormone Sensitivity in Breast Cancer
This is a biomedical and prospective study of interventional type. The trial will include 29 patients over a period of 15 months + 24 months of follow up maximum.
- Trial name
- MIRHO (NCT01612871)
- Testing
- Tamoxifen, Letrozole , Anastrozole, Exemestane
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- Institut Claudius Regaud
Depression
Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications
A pilot study of mapping the peripheral plasma micro-RNA and proteomics patterns in depressive patients, treated with SSRI medications. It is an observational clinical bio-markers laboratory controlled research with no device.
- Trial name
- MIRPROT (NCT01681407)
- Where
- Israel
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Sarcopenia
Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle Growth
Sarcopenia is a predictor of functional-limitation, leading to loss of independence, lowered quality of life, and ultimately death.
- Trial name
- NCT02638454
- Testing
- Acute Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Cancer
iDentification and vAlidation Model of Liquid biopsY Based cfDNA Methylation and pRotEin biomArKers for Pancreatic Cancer (DAYBREAK Study)
DAYBREAK is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, serum protein markers, blood miRNA markers and others, in which of 450…
- Trial name
- NCT05495685
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Reactive Hyperemia, Micro RNA
Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training
Epidemiological studies based on Danish registries have observed that Danish male firefighters have more cardiovascular disease, infertility diagnose and a trend to increased risk of cancer than other Danish employed males.
- Conditions
- Reactive Hyperemia, Micro RNA, Heart Rate Variability, DNA Strand Breaks
- Trial name
- BIOBRAND3 (NCT05753254)
- Testing
- Firefighting training exercises with no fire, Firefighting training exercises under wood fire, Firefighting training exercises under gas fire
- Where
- 2 sites in Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Fibroblast Growth Factor 23, Anemia
FGF23 and Cardiovascular Damage in Anemia With an Without Chronic Kidney Disease.
Anemia is associated with cardiovascular disease. Iron deficiency is usually induced in chronic kidney disease (CKD). In clinical studies, an inverse association between serum levels of iron and fibroblast growth factor 23…
- Conditions
- Fibroblast Growth Factor 23, Anemia, CKD
- Trial name
- NCT05356325
- Where
- Spain
- Volunteers
- 401 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
MicroRNA Profile, Liver Transplant
MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential…
- Conditions
- MicroRNA Profile, Liver Transplant, Organ Donor
- Trial name
- NCT06611046
- Testing
- organ donor
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mar Dalmau
microRNAs in Attention-deficit/Hyperactivity Disorder
Epigenetics in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders in children and adolescents. ADHD's nosology is largely based on clinical phenomenology that includes such symptoms as inattention…
- Trial name
- NCT04860024
- Where
- Taiwan
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Psoriasis
miRNAs and mRNAs in Psoriasis
PURPOSE - The purpose of this study is to identify and determine miRNA expression and their targets before and during biological treatment of psoriatic patients.
- Trial name
- NCT01604902
- Testing
- 4 mm punch biopsies
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Sarcopenic Obesity
Sarcopenic Obesity as a Risk of Premature Aging
Recently, numerous signaling proteins derived from adipose tissue and/or skeletal muscle have been described and are involved in the pathogenesis of obesity and the pathophysiology of aging.
- Conditions
- Obesity, Sarcopenic Obesity, Aging
- Trial name
- SARCOBEAGING (NCT05443711)
- Testing
- No intervention, observational study
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospital de Leon
Osteoarthritis, Knee, Epigenetic Disorder
Exercise on microRNA in Osteoarthritis
The present study is a prospective cohort study. This study will be conducted to determine the change in miRNA levels with exercise in knee Osteoarthritis (OA) patients.
- Conditions
- Osteoarthritis, Knee, Epigenetic Disorder, Quality of Life, Depression
- Trial name
- NCT05869630
- Testing
- Exercise Programme, Experiments
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Irritable Bowel Syndrome, Digestive System Diseases
Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome
In the investigators study, the investigators will focus on the screening of the related proteins and miRNA to IBS in order to reveal the possible clues or molecular mechanism for this disorder.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Gastrointestinal Diseases, Intestinal Diseases
- Trial name
- IBS (NCT01028898)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Plasma and Platelet microRNAs in Clopidogrel Low Response Patients
Clopidogrel is an important anti-platelet agent.However, about 30% of the coronary artery disease patients presented clopidogrel low response (CLR).Previous studies showed that the cardiovascular event ratio of the CLR patients…
- Trial name
- PPRC (NCT02447809)
- Testing
- Clopidogrel, acetylsalicylic acid (ASA)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hemodialysis Patients, Diabetes
Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients
The aim of this research is to study how vitamin D affects various aspects of the disease process, such as inflammation, coagulation (ADAMTS13 and WVF) and miRNAs, in Diabetic kidney disease hemodialysis patients.
- Trial name
- NCT02245633
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Meir Medical Center
Bronchiolitis Obliterans
Lung Function, LCI, Bronchial Inflammation and Epigenetics of Patients With BO
Bronchiolitis obliterans is a chronic disease in which a persistent inflammatory process leads to obliteration of the small airways.
- Trial name
- FRABO-03 (NCT02627833)
- Testing
- observation
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
To Determine the Levels of miRNA1 and miRNA133a Before and After Exercise
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes
"The goal of this clinical trial is to investigate the levels of microRNA-1 (miRNA-1) and microRNA-133a (miRNA-133a) after acute neuromuscular exercise (NME) in human saliva.
- Trial name
- NCT06083610
- Testing
- miRNA levels analysis from saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Lymphangioleiomyomatosis
Discovery of Sirolimus Sensitive Biomarkers in Blood
Background: Lymphangioleiomyomatosis (LAM) is a rare, progressive disease. It usually affects women in the prime of their lives. It typically results in lung destruction.
- Trial name
- NCT03304678
- Testing
- Sirolimus 2mg
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University