Clinical trials: MicroRNAs
Childhood Chronic Kidney Disease
Cardiovascular Comorbidity in Children With Chronic Kidney Disease
This 3-year study will systematically evaluate the prevalence, clinical symptoms, and progression of CV and kidney disease and assess the impact of potential genetic, pharmacological, behavior, and environmental risk factors in a…
- Trial name
- NCT03227055
- Where
- Taiwan
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
B-cell Acute Lymphoblastic Leukemia
Evaluation of ProALL miRs in Blood Specimen for Prediction of ALL Relapse Risk
Previous findings have shown that a biomarker comprised of the three microRNAs (miRs) miR-451, miR-151-5p and miR-1290 can independently predict precursor B-cell acute lymphoblastic leukemia (B- ALL) patients' risk for relapse…
- Trial name
- NCT03000335
- Where
- 2 sites in Israel
- Volunteers
- 65 people
- Sponsor
- Curewize Health Ltd.
Paracetamol Overdose
The Markers and Paracetamol Poisoning Study 2
Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission.
- Trial name
- MAPP2 (NCT03497104)
- Testing
- Surplus blood tests
- Where
- United Kingdom
- Volunteers
- 464 people
- Sponsor
- NHS Lothian
Cardiomyopathies, Amyloidosis Cardiac
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging…
- Conditions
- Cardiomyopathies, Amyloidosis Cardiac, Fabry Disease, Arrhythmogenic Cardiomyopathy
- Trial name
- CMPMIRNA (NCT06813443)
- Where
- 3 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Polycystic Ovary Syndrome, Insulin Resistance
MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome
The aim of this study is to explore the microRNA profile in serum of women with Polycystic Ovary Syndrome and investigate the correlation between the microRNA profile and markers of metabolic syndrome.
- Trial name
- NCT03142633
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Holbaek Sygehus
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Network-based Approach in Type 2 Diabetes and Its Cardiovascular Risk
PIRAMIDE study design will test the hypothesis that simultaneous interactions between DNA methylation and microRNAs may hit T2D candidate genes and predict the development of T2D-related cardiovascular complications.
- Trial name
- PIRAMIDE (NCT03792607)
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Giuditta Benincasa
Primary Hyperparathyroidism, Osteoporosis, Postmenopausal
Circulating miRNA in Primary Hyperparathyroidism
The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with osteoporosis undergoing thyroidectomy, and to…
- Trial name
- NCT03931109
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Pennsylvania
Colorectal Cancer, Colorectal Neoplasms
Predicting Local and Distant Recurrence in T1 Colorectal Cancer
Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- T1CR (NCT06314971)
- Testing
- Tw1CE
- Where
- 3 sites in United States, Japan and 1 more
- Volunteers
- 138 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
An In-situ Detection for MicroRNA
We designed a new in-site detection method for MicroRNA in the serum of patients with breast cancer.
- Trial name
- NCT06529614
- Testing
- In-situ detection for Micro-RNA
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Periodontal Diseases, Inflammatory Response
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers for the diagnosis and prognosis of diseases.
- Trial name
- NCT03510702
- Testing
- Levels of epigenetic biomarkers present in the gingival fluid and its possible relationship with bone metabolism.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Abortion, Habitual
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage
The definition of recurrent spontaneous abortion (RSA) has changed over the years, and most societies now advocate defining RSA as two or three consecutive or discontinuous miscarriages with the same sexual partner before 24…
- Trial name
- microRNA410 (NCT05658445)
- Testing
- evacuation
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Assiut University
Oral Lichen Planus, Oral Cancer
the Oncogenic Potential of Salivary miRNA-93 and miRNA-412-3P in Oral Lichen Planus Patients
Assessment The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus
- Trial name
- NCT05400057
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moataz Mahmoud
Resectable Pancreatic Adenocarcinoma
Identify microRNAs in Cachexia in Pancreatic Carcinoma
The purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.
- Trial name
- SCC-miRPanCa (NCT05275075)
- Testing
- Pancreatic cancer microRNA and messenger RNA expression.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Kidney Transplant
Effects Of Propofol And Sevoflurane On Plasma Mirna Levels İn Living Kidney Donors
Surgical interventions and associated tissue trauma induce a complex systemic inflammatory stress response characterized by the activation of neuroendocrine, metabolic, and immunological systems.
- Trial name
- NCT07760402
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Exosomes, Newborn
Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity
Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the…
- Conditions
- Exosomes, Newborn, Bone Diseases, Metabolic
- Trial name
- NCT06368154
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hunan Children's Hospital
Subarachnoid Hemorrhage
MicroRNA Diagnostics in Subarachnoid Hemorrhage
The purpose of this study is to compare the profile of microRNA in cerebrospinal fluid from patients suffering subarachnoid hemorrhage with and without delayed cerebral ischemia.
- Trial name
- NCT01791257
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Establish the Efficacy Between the Four Schemes in Terms of the Aggressiveness of the Tumors According to the Gleason Classification, Establish the Efficacy Between the Four Schemes in Terms of Morbidity Associated With the Technique
Impact of Magnetic Resonance and Biomarkers for Screening for Prostate Cancer. Cost-effectiveness Analysis
Objectives: To establish if there are differences between an ultrasound-guided transrectal prostate biopsy (BPTE) and a transperineal prostatic biopsy (BPTP) with and without a multiparametric Magnetic Resonance (RMmp) in…
- Conditions
- Establish the Efficacy Between the Four Schemes in Terms of the Aggressiveness of the Tumors According to the Gleason Classification, Establish the Efficacy Between the Four Schemes in Terms of Morbidity Associated With the Technique, Establish the Efficacy Between the Four Schemes in Terms of the Patient's Subjective Perception Regarding Pain and Quality of Life, Establish the Association of the Tumor Biomarker in the Early Detection and Aggressiveness of Tumors
- Trial name
- RMPBX201801 (NCT04283032)
- Testing
- Multiparametric magnetic resonance
- Where
- Spain
- Volunteers
- 628 people
- Sponsor
- InvestigatorUrologyIBSAL
Ovarian Cancer, Endometrial Cancer
Exploring the Potential of Novel Biomarkers Based on Plasma microRNAs for a Better Management of Pelvic Gynecologic Tumors
This trial is a non-randomized, open label and multicenter study. It aims to : for endometrial cancer.:validate the 5-miR index assessed in plasma samples as a diagnostic marker to assess the risk of lymph node metastases for…
- Trial name
- GYNO-MIR (NCT03776630)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontal Diseases Inflammation
Micro Ribonucleic Acid (miRNA) Expression and Inflammatory Factors in Patients With Parkinson's and Periodontal Disease
MicroRNAs are important regulators of the immune and inflammatory response to bacterial pathogens during periodontal disease.The aim of this study was to evaluate the possible miRNA type for Parkinson's in saliva of orally…
- Trial name
- NCT07099378
- Testing
- Saliva and Serum
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medipol University
Migraine
Plasma Levels of CGRP and Expression of Specific microRNAs in Blood Cells of Episodic and Chronic Migraine Subjects
Migraine can manifest with an episodic or chronic pattern in a continuum of disease severity. Multiple factors are associated to the transformation of the pattern form episodic to chronic.
- Trial name
- CGRP-RNA (NCT04473976)
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation