Clinical trials: MicroRNAs
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
This study aims to investigate the clinical value of small extracellular vesicle (sEV) miRNAs as predictive biomarkers for immunochemotherapy efficacy in extensive-stage small cell lung cancer (ES-SCLC).
- Trial name
- NCT07070011
- Testing
- EC/EP + ICIs
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Chest Hospital of Shanghai Jiao Tong University
Breast Cancer
Circulating miRNAs as Biomarkers of Hormone Sensitivity in Breast Cancer
This is a biomedical and prospective study of interventional type. The trial will include 29 patients over a period of 15 months + 24 months of follow up maximum.
- Trial name
- MIRHO (NCT01612871)
- Testing
- Tamoxifen, Letrozole , Anastrozole, Exemestane
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- Institut Claudius Regaud
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Glycogen Depletion
Carbohydrate Availability and microRNA Expression
This investigation will examine the impact of skeletal muscle glycogen stores on skeletal muscle and circulating microRNA expression and exogenous carbohydrate oxidation.
- Trial name
- NCT03250234
- Testing
- Adequate Carbohydrate, Low Carbohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pancreatic Ductal Adenocarcinoma
Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer
This study aims to develop and validate a predictive microRNA (miRNA) panel to assess the response to neoadjuvant chemotherapy (NACT) in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC).
- Trial name
- PRECEPT (NCT07226154)
- Testing
- Small RNA sequencing, PRECEPT assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- City of Hope Medical Center
Pulmonary Disease, Chronic Obstructive, Pneumonia, Bacterial
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis
The long-term goals of this study are (a) to understand the biological underpinnings for the increased incidence of community-acquired pneumonia in patients with chronic obstructive pulmonary disease (COPD) who are treated with…
- Trial name
- NCT03034642
- Testing
- Bronchoscopy with bilateral bronchoalveolar lavages
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Ann Arbor Healthcare System
Congenital Heart Disease, Single-ventricle
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery.
- Conditions
- Congenital Heart Disease, Single-ventricle, Thrombosis
- Trial name
- EVmiRNA (NCT06434207)
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation
Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction
Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation, Exercise Training, Exercise Adaptations
- Trial name
- PrédicRéa (NCT07164911)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier de Corbie
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Type 2 Diabetes, Vascular Calcification
Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)
Coronary artery calcification (CAC) is a common complication of type 2 diabetes mellitus(T2DM), which can significantly increase all-cause mortality and the incidence of serious cardiovascular events, and increase the burden of…
- Conditions
- Type 2 Diabetes, Vascular Calcification, Coronary Artery Calcification, Strains
- Trial name
- NCT04889053
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- University of South China
Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation (HSCT)
Clinical Performance of SE-SPTM-PCR in Detecting Hcmv-miR-UL22A-5p After Hematopoietic Stem Cell Transplantation
This study aims to evaluate the clinical performance of a novel microRNA-based detection platform, SE-SPTM-PCR, for identifying cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (HSCT).
- Conditions
- Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation (HSCT), CMV Reactivation, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- SESPTM-CMV (NCT07181330)
- Testing
- SE-SPTM-PCR microRNA assay
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ting YANG
Basal Cell Carcinoma
Microarray Analysis of microRNA Expression in Basal Cell Carcinoma
Perturbations in microRNA (miRNA) expression profiles has been reported for a variety of cancers. This study will be an exploratory analysis of miRNA expression in basal cell carcinoma by miRNA expression profiling using…
- Trial name
- NCT01498250
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Ruhr University of Bochum
MIRAS, Testicular Abnominalies
Could miRNAs be Used as Markers for Distinguishing Undescended Testicles From Retractile Testicles
Background: Undescended testicles (UDTs) are common in male infants. Untreated UDT poses risks such as infertility (IF), testicular cancer (TC), and testicular torsion (TT).
- Conditions
- MIRAS, Testicular Abnominalies, Undescended Testes
- Trial name
- miRNA (NCT07315737)
- Testing
- miRNA
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dr. Mevlüt Keleş
Metabolic Syndrome X
Effect of Food Consumption on microRNA Related to Metabolic Syndrome
The objective of the Project is to assess the effect of traditional food on the expression of micro-ribonucleic acid (miRNA), which regulate genes related to glucose metabolism. It will be a randomized experimental research.
- Trial name
- EFCMRNAMS (NCT02606812)
- Testing
- Traditional-food
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Cerebral Hemorrhage
Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral bleeding also known as spontaneous intracerebral hemorrhage (sICH) constitute 10-15 % of all apoplexies.
- Trial name
- NCT02326571
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Christian Kærsmose Friberg
D011471, D064129
CIRCULATING MICRO-RNA (miRNA) AND AR-V7 MUTATIONAL STATUS IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (CRPC): PRIMERA+ STUDY (PROSTATE CANCER INNOVATING MARKERS OF EXPECTED RESPONSE TO AGONIST LHRH+ ANDROGEN RECEPTOR INHIBITION
Observational prospective study investigating the plasmatic levels of miRNA according to AR-V7 mutational status in mCRPC patients receiving standard of care therapy.
- Conditions
- D011471, D064129, D035683, D009360
- Trial name
- PRIMERA (NCT04188275)
- Testing
- Periodic ARV7 and miRNA evaluation
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Autism Spectrum Disorder, Developmental Delay
A Salivary miRNA Diagnostic Test for Autism
The goal of this study is to validate a panel of miRNAs that distinguish children with autism spectrum disorder (ASD) from their non-ASD peers with a positive MCHAT-R.
- Trial name
- NCT02832557
- Testing
- Salivary collection, Vineland Adaptive Behavior Scale-III Assessment, Medical history questionaire
- Where
- United States
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
IVF, Fertility Preservation
Micro RNA Profile in the Ovarian Follicle Fluid of Transgender Men
The effects of gender transitioning, particularly the effects of testosterone exposure in transgender men, on the oocyte and embryo development are largely unknown.
- Conditions
- IVF, Fertility Preservation, Infertility
- Trial name
- NCT03725280
- Testing
- IVF
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Liver Disease and Cirrhosis, Chronic Liver Disease
hepatomiR cACLD Study
This study looks to gather data on hepatomiR, a CE-certified test already intended for gauging liver-related outcomes, in order to define a cut-off regarding specific decompensation events (ascites, variceal hemorrhage, hepatic…
- Conditions
- Chronic Liver Disease and Cirrhosis, Chronic Liver Disease, Portal Hypertension
- Trial name
- NCT06432582
- Testing
- hepatomiR
- Where
- Austria
- Volunteers
- 156 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Biomarker
Validation Study of a Serum-miRNA Signature in Glioma Patients.
Prospective, multicenter, noninterventional, nonprofit study of a cohort of patients with glioma, aimed at validating miRNA-serum signatures associated with IDH1 status and prognosis, as reliable, specific and sensitive…
- Trial name
- NCT06178692
- Testing
- Validation of miRNA-serum signatures associated with IDH1 status
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute