Clinical trials: Microbiome Analysis
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Volatile Organic Compounds, Microbiome
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis
- Trial name
- NCT05412758
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Parkinson Disease
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Currently, a diagnostic test for early PD does not exist.
- Trial name
- PANORAMA (NCT06453226)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dry Eyes
Ocular Surface Dry Eye Microbiome
The investigators seek to characterize the identity of all microorganisms residing on the eye's surface (conjunctiva) in healthy eyes and those with dry eye syndrome, using a combination of analyses.
- Trial name
- NCT02306668
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Washington
Periodontal Disease, Periodontitis
Antibiotic Resistance Genes in Periodontitis
Antimicrobial resistance (AMR) is a major global public health concern, and the oral microbiome may serve as an important reservoir of antibiotic resistance genes (ARGs).
- Conditions
- Periodontal Disease, Periodontitis, Antibiotic Resistance Genes
- Trial name
- NCT07887204
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Obesity
Gut Microbiome Based Analysis of High Protein High Fat Diet
The aim of this study was to determine body mass reduction and microbiota composition change after the weight loss diet (50 % fat, 25 % proteins and 25 % carbohydrates).
- Trial name
- NCT04681664
- Testing
- High fat diet
- Where
- Estonia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Center of Food and Fermentation Technologies
Helicobacter Pylori Infection
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H.
- Trial name
- NCT03730766
- Testing
- Esomeprazole, Amoxicillin, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy
Batch Fermentation and Microbiome Analysis
The correlation between diet and microbiota as well as the effect of microbiota on human health is well established. Studies have shown that people following specific diets have different microbiome profile compared to those…
- Trial name
- NCT06097130
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Non-small Cell Lung Cancer, Colorectal Cancer
ARGONAUT: Stool and Blood Sample Bank for Cancer Patients
ARGONAUT is a longitudinal, prospective, observational study that will enroll up to 5,000 advanced-stage cancer patients of diverse racial backgrounds to collect data used to develop precision microbiome medicines and for the…
- Conditions
- Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
- Trial name
- NCT04638751
- Testing
- Immunotherapy, Chemotherapy, CRC surgical resection
- Where
- 10 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Persephone Biosciences
Healthy Diet, Gastrointestinal Microbiome
Study the Effect of Water Kefir Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the water kefir consumption. The main questions are to evaluate the potential probiotic drink can have beneficial effect on the gut microbiota.
- Conditions
- Healthy Diet, Gastrointestinal Microbiome, Probiotics
- Trial name
- NCT05657730
- Testing
- Water Kefir beverage
- Where
- Sweden
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy Volunteers
Sample Collection From Healthy Volunteers for Assay Optimization
Background: The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. They study how parts of living things come together to make a whole.
- Trial name
- NCT03538600
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oral Lichen Planus
Metagenomic Analysis of the Oral Microbiome in Patients With Oral Lichen Planus: A Pilot Study in the Turkish Population
Lichen planus is a common chronic mucocutaneous inflammatory disease that affects the skin, nails, eyes, urogenital system, and oral mucosa. Oral lichen planus (OLP) specifically occurs in the oral cavity.
- Trial name
- NCT07137156
- Testing
- cytobrush, next-generation sequencing
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Oxalate, Primary Hyperoxaluria, Microbiome
Descriptive Analysis of Gut Microbiome Alterations in Hyperoxaluric Patients
To characterize the microbiome in 4 groups of subjects (primary hyperoxaluria type I (PH1), idiopathic CaOx stone, enteric hyperoxaluria (EH) and healthy participants) by comparing the number of species and diversity of the…
- Trial name
- NCT02794649
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA New York Harbor Healthcare System
Generalized Aggressive Periodontitis
Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants.
Generalized aggressive periodontitis (GAgP) is a multifactorial disease related to several aspects that influence its installation and progression.
- Trial name
- NCT03933514
- Testing
- Plaque control
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Inflammatory Bowel Diseases, Crohn Disease
Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living…
- Trial name
- OPTIMIST (NCT06453720)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
Multi-omics Database Construction of Healthy Korean Volunteers
The goal of this prospective, observational study is to collect health-related data including microbiome, blood samples, and dietary habits from the oral and gastrointestinal tracts in healthy subjects.
- Trial name
- NCT06183697
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Autoimmune Gastritis
Clinical Characteristics, Lifestyle and Multi-omics Analysis in Autoimmune Gastritis
This research will be conducted nationwide in patients with autoimmune gastritis, focusing on their clinical characteristics, possible risk factors, and multi-omics analysis.
- Trial name
- NCT05820607
- Testing
- Microbiome, metabolome, transcriptome, genome
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Rotavirus
The Influence of the Microbiome on Rotavirus Vaccine Immunogenic Response in Infants in Karachi, Pakistan
This is a nested case-control study within an ongoing rotavirus vaccine immunogenicity trial in Karachi, Pakistan. The primary study aim is to compare the fecal microbiota composition and diversity of infants who do (control) and…
- Trial name
- NCT03031743
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Inflammatory Bowel Diseases
Microbiome and Genetic Analysis of Familial IBD
Inflammatory bowel disease(IBD) is a chronic inflammatory condition for gastrointestinal tract. Regarding its pathogenesis, there has been numerous studies to reveal the complex association between genetic and environmental…
- Trial name
- NCT03515070
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center