Clinical trials: Microdosing
Fibromyalgia (FM)
Effects of a Isokinetic Exercise in Women With Fibromyalgia
Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and functional impairment, which significantly affects quality of life.
- Trial name
- FibrodEx (NCT07483216)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- European University Miguel de Cervantes
Fibrosis, Lung Cancer
Imaging FIB ONE in the Human Lung Using Endomicroscopy
While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function.
- Trial name
- FIB ONE (NCT02604862)
- Testing
- FIB ONE, AZD1236
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Edinburgh
Head and Neck Squamous Cell Carcinoma
PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC
This is a multi-center, open-label, Phase 0 substudy designed to evaluate the localized pharmacodynamics (PD) of rilvegostomig, volrustomig, sabestomig, and AZD9592 within the tumor microenvironment (TME) when administered…
- Trial name
- NCT06366451
- Testing
- Rilvegostomig, Volrustomig, Sabestomig
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Presage Biosciences
Carcinoma, Non-Small-Cell Lung, Urinary Bladder Neoplasms
Clinical Study of Microdosing Carboplatin in Lung or Bladder Cancer
Carboplatin kills cancer cells mainly through induction of DNA damage (drug-DNA adducts). The goal of this clinical trial is to determine if chemoresistance to carboplatin can be identified by measuring carboplatin-induced DNA…
- Trial name
- NCT01261299
- Testing
- Carbon-14-labeled carboplatin
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of California, Davis
Pain, Acute Pain
The Role of NaV1.8 in Human Pain Models
This study aims to understand how NaV1.8, a specific type of sodium channel found in peripheral nerves, contributes to different types of pain in humans.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07511400
- Testing
- Suzetrigine, Lidocaine (drug), Control Solution
- Where
- Austria
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Opioid Use Disorder, Opioid Withdrawal
Evaluating the Pharmacokinetics and Patient Outcomes of Buprenorphine Microdosing
There are more than 2.1 million people in the United States with opioid use disorder, and according to preliminary data from the US Centers for Disease Control and Prevention opioid overdose deaths rose 36% to more than 69,000…
- Trial name
- NCT05307458
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United Health Services Hospitals, Inc.
Bacterial Respiratory Infections
Microdosing of BAC ONE to the Distal Lung
Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which…
- Trial name
- BAC ONE (NCT02558062)
- Testing
- BAC ONE administration
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Depression, Anxiety, Distress, Emotional
PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the safety, feasibility, therapeutic dose, and preliminary efficacy of psilocybin microdosing to treat psychological distress among patients…
- Trial name
- NCT04754061
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Cognitive Change, Creativity
Naturalistic Study of Microdosing With Psilocybin
This study seeks to understand the neural, cognitive and behavioral effects of low doses of psilocybin administered in the form of dried mushroom material (0.5 g of Psilocybe cubensis) consumed in natural settings following a…
- Conditions
- Cognitive Change, Creativity, Mood Change, Sleep
- Trial name
- NATMICRO (NCT05160220)
- Testing
- Psilocybin
- Where
- Argentina
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Health-Related Physical Fitness
Effects of Microdosed Resistance Training During Physical Education on Health-Related Fitness in Adolescents
This study will examine whether short bouts of resistance training incorporated into physical education lessons can improve health-related physical fitness in secondary school students aged 15-16 years.
- Trial name
- NCT07845864
- Testing
- Resistance training microdosing during physical education
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Opioid-use Disorder
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments
This is a multi-centre, open-label RCT at four Emergency Departments (EDs) in British Columbia and Alberta. The purpose of the current study is to compare the effectiveness of buprenorphine/naloxone microdosing and standard…
- Trial name
- NCT04893525
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in Canada
- Volunteers
- 658 people
- Sponsor
- University of British Columbia
Perfusion; Complications
Microdosing ICG for Serial Colonic Perfusion Study During Surgery
using microdosing of ICG vs regular dosing of ICG for perfusion assessment during surgery
- Trial name
- NCT06254833
- Testing
- micro dosing of ICG
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shanglei Liu
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult
A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors
This is a multi-center, single arm, open-label, localized pharmacodynamic biomarker Phase 0 trial designed to study the biological effects within the tumor microenvironment of PBA-0405 when administered intratumorally in…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
- Trial name
- NCT06273852
- Testing
- PBA-0405
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pure Biologics S.A.
Major Depressive Disorder
Microdosing Psychedelics to Improve Mood
This trial aims to examine the safety and efficacy of small (2mg) sub-hallucinogenic doses of psilocybin in people with Major Depressive Disorder.
- Trial name
- NCT05259943
- Testing
- Psilocybin first
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Rotem Petranker
Meditation, Microdosing
Optimizing Microdosing and Meditation
The goal of this clinical trial is to test the feasibility of combining meditation with psilocybin microdosing in healthy adults. The main questions it aims to answer are: 1. Recruitment and retention feasibility 2.
- Trial name
- OMM (NCT06560658)
- Testing
- Psilocybin, Meditation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Plyometric Exercises, Soccer Performance
Micro-Dosed vs. Traditional Plyometric Training in Elite Youth Soccer
The goal of this clinical trial is to learn if a micro-dosed plyometric training program works as well as a traditional plyometric program for improving speed and explosive abilities in elite under-19 soccer players during the…
- Conditions
- Plyometric Exercises, Soccer Performance, Speed, Explosive Strength
- Trial name
- TRMD-PLYO_U19 (NCT07193706)
- Testing
- Traditional group training program, Micro-dosed group training program
- Where
- Czechia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Matej Bel University
Acute Lung Injury
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
Seriously ill patients may develop a complication called acute lung injury (ALI), a form of inflammation in which lung tissue is filled by fluid containing white blood cells called neutrophils.
- Trial name
- NAP (NCT01532024)
- Testing
- Microdose of NAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Alzheimer Disease
A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Ligand 11C-JNJ-63779586 in the Human Brain
The purpose of this study is to investigate the total body biodistribution and radiation dosimetry of 11C-JNJ-63779586 by Positron Emission Tomography (PET) in healthy young adult males (Part A); to estimate and compare the…
- Trial name
- NCT03089918
- Testing
- 11C-JNJ-63779586
- Where
- 2 sites in Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Psychological Distress
Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)
About 30-50% of patients with advanced illness experience depression, anxiety, or decreased sense of purpose and autonomy. Together, these are called psychological distress.
- Trial name
- NCT07063862
- Testing
- Psilocybin
- Where
- 7 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Bruyère Health Research Institute.
Healthy
Intra-Arterial Microdosing: Proof-of-Concept in Humans
The purpose of this protocol is to demonstrate that intra-arterial administration of a drug can generate information in a manner that faithfully mimics effects of systemic administration but with little or no systemic effects.
- Trial name
- IAM-POC (NCT02304211)
- Testing
- Insulin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University