Clinical trials: Microvasculature
Cardiovascular Diseases, Cardiovascular Risk Factor
Local Antioxidant Therapy Vasoconstriction Effects in Different Races
Cardiovascular disease (CVD) afflicts nearly one-third of the adult population with all races and ethnicities represented in CVD prevalence.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03684213
- Testing
- Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Diabetic Retinopathy
Assessment of Retinal Microvascular Changes by OCT Angiography in Diabetic Retinopathy
This observational cross-sectional study aims to assess retinal microvascular changes using optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy.
- Trial name
- NCT07747428
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Cognitive Function
The Effect of Aronia Melanocarpa Extract on Cognitive Function
There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance .
- Trial name
- NCT03793777
- Testing
- Aronia
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Controlled Hypotension for Nasal Surgeries
Effects of Different MAP Targets on Ocular Perfusion and Optic Nerve Microvasculature During Rhinoplasty
This randomized controlled trial aims to evaluate the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on ocular perfusion and optic nerve head microvasculature in patients undergoing…
- Trial name
- NCT07832305
- Testing
- Lower MAP Target Strategy (50-60 mmHg), Higher MAP Target Strategy (60-70 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hitit University
Diabetes Complications
Retinal Microvasculature by Optical Coherence Tomography Angiography During Integrating Physical Activity in Diabetic Subjects.
Diabetic retinopathy is a common condition of diabetes and can lead to blindness, making it one of the most feared complications of diabetes.
- Trial name
- OCTACTIPH (NCT05645068)
- Testing
- Optical Coherence Tomography Angiography, multidisciplinary care program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Long Covid19, Post COVID-19 Condition
All Eyes on PCS - Analysis of the Retinal Microvasculature in Patients With Post-COVID-19 Syndrome
The goal of this observational, prospective study is to in depth analyze the retinal microvasculature in patients with Post-COVID-19 Syndrome (PCS).
- Conditions
- Long Covid19, Post COVID-19 Condition, Endothelial Dysfunction
- Trial name
- NCT05635552
- Testing
- Dynamic retinal vessel analysis (DVA), Optical coherence tomography (OCT), Biochemistry and immune phenotyping
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Retinal Vascular
Retinal Microvasculature Before and After Silicone Oil by OCTA
Prospective study to assess the retinal microvasculature, optic nerve head vasculature and retinal sensitivity using OCTA and microperimetry before and after silicone oil removal.
- Trial name
- NCT04928196
- Testing
- Microperimtery and optical coherence tomography angiography OCTA
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Myopia
Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness…
- Trial name
- NCT04631991
- Testing
- Comprehensive ophthalmologic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Akdeniz University
Vision Disorders
Pilot Clinical Evaluation of Approved Contact Lenses
This is a pilot evaluation to assess the feasibility of using novel imaging process to characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; and conjunctival microvasculature including…
- Trial name
- NCT02540122
- Testing
- Marketed Contact Lens 1, Marketed Contact Lens 2, Marketed Contact Lens 3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Cervix Cancer
Investigation of Cervix Tumor Oxygenation and Microvasculature Using Magnetic Resonance Techniques
In cervix cancer tumor oxygen levels and fluid pressure in the tumor have been shown to be related to patient outcome. Analysis of the way tumors enhance after intravenous contrast injection using MRI and CT can be used to…
- Trial name
- NCT00242034
- Testing
- CT and MRI with contrast
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
End Stage Chronic Renal Failure, Renal Transplant
Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function
This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery.
- Conditions
- End Stage Chronic Renal Failure, Renal Transplant, Microvascular Changes, Microvascular Circulation
- Trial name
- MUST-D (NCT07645599)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roderick Tan
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
MoDi Twin Placental Imaging
Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or…
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Monochorionic Twins, Ultrasound Doppler
- Trial name
- NCT07667647
- Testing
- Verasonics Vantage 256 Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Carilion Clinic
Insulin Resistance
Mechanisms of Insulin Resistance and Exercise in South Asians
This study determines the effect of aerobic and resistance exercise training on whole-body and skeletal muscle insulin sensitivity in south Asians and evaluate the mechanisms which contribute to improvements in insulin…
- Trial name
- NCT04007926
- Testing
- Aerobic exercise programme, Resistance exercise programme
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Diabetic Retinopathy, DR
Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography
the aim of this study is to assess the impact of duration of DM on OCTA parameters in diabetic patients without clinical Diabetic retinopathy.
- Trial name
- NCT06457295
- Testing
- optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Myocardial Revascularization Surgery With Extracorporeal Circulation
Retinal Microvascular Network and Coronary Revascularization Surgery at the Dijon University Hospital
When coronary artery disease cannot be treated with medication, revascularization surgery can be performed. Although there have been many advances in recent years, this surgery is still associated with a high incidence of…
- Trial name
- MRCC (NCT05315349)
- Testing
- Complete ophthalmological check-up, Blood sampling
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Acute Myocardial Infarction
Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide further improvement in myocardial…
- Trial name
- NCT00302419
- Testing
- intracoronary infusion,, primary percutaneous coronary angioplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Istanbul University
Estrogen, Cardiovascular Diseases
Estrogen and Microvascular Function
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: give one blood draw of 5 mL have one Dexa Scan taken to measure adipose and muscle mass have a camera…
- Conditions
- Estrogen, Cardiovascular Diseases, Microvasculature, Oral Contraceptive Use
- Trial name
- NCT06043310
- Testing
- Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Cognitive Change
Yoga Training and Retinal Vasculature With Parkinson's Disease
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function in persons with Parkinson's disease.
- Trial name
- NCT06194227
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional Yoga
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Miami