Clinical trials: Microvasculature
Cardiovascular Diseases, Cardiovascular Risk Factor
Local Antioxidant Therapy Vasoconstriction Effects in Different Races
Cardiovascular disease (CVD) afflicts nearly one-third of the adult population with all races and ethnicities represented in CVD prevalence.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03684213
- Testing
- Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cognitive Function
The Effect of Aronia Melanocarpa Extract on Cognitive Function
There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance .
- Trial name
- NCT03793777
- Testing
- Aronia
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Long Covid19, Post COVID-19 Condition
All Eyes on PCS - Analysis of the Retinal Microvasculature in Patients With Post-COVID-19 Syndrome
The goal of this observational, prospective study is to in depth analyze the retinal microvasculature in patients with Post-COVID-19 Syndrome (PCS).
- Conditions
- Long Covid19, Post COVID-19 Condition, Endothelial Dysfunction
- Trial name
- NCT05635552
- Testing
- Dynamic retinal vessel analysis (DVA), Optical coherence tomography (OCT), Biochemistry and immune phenotyping
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Retinal Vascular
Retinal Microvasculature Before and After Silicone Oil by OCTA
Prospective study to assess the retinal microvasculature, optic nerve head vasculature and retinal sensitivity using OCTA and microperimetry before and after silicone oil removal.
- Trial name
- NCT04928196
- Testing
- Microperimtery and optical coherence tomography angiography OCTA
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Vision Disorders
Pilot Clinical Evaluation of Approved Contact Lenses
This is a pilot evaluation to assess the feasibility of using novel imaging process to characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; and conjunctival microvasculature including…
- Trial name
- NCT02540122
- Testing
- Marketed Contact Lens 1, Marketed Contact Lens 2, Marketed Contact Lens 3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Insulin Resistance
Mechanisms of Insulin Resistance and Exercise in South Asians
This study determines the effect of aerobic and resistance exercise training on whole-body and skeletal muscle insulin sensitivity in south Asians and evaluate the mechanisms which contribute to improvements in insulin…
- Trial name
- NCT04007926
- Testing
- Aerobic exercise programme, Resistance exercise programme
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Diabetic Retinopathy, DR
Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography
the aim of this study is to assess the impact of duration of DM on OCTA parameters in diabetic patients without clinical Diabetic retinopathy.
- Trial name
- NCT06457295
- Testing
- optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Estrogen, Cardiovascular Diseases
Estrogen and Microvascular Function
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: give one blood draw of 5 mL have one Dexa Scan taken to measure adipose and muscle mass have a camera…
- Conditions
- Estrogen, Cardiovascular Diseases, Microvasculature, Oral Contraceptive Use
- Trial name
- NCT06043310
- Testing
- Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Health Status
Effect of Fibre Supplementation on Mixed-meal Challenge Response
Improving healthy physiological processes through nutritional intervention, as opposed to restoring physiology after disease occurrence, is an important new avenue for the reduction of disease burden in the population.
- Trial name
- NCT04829396
- Testing
- Fibre mixture
- Where
- Netherlands
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Cognitive Impairment, Progressive, Cerebral Small Vessel Diseases
Circuit Training and Retina
The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.
- Trial name
- NCT05714813
- Testing
- High-Speed Circuit Resistance Training, Lecture on Diet, Exercise and Cognition
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Dyslipidemia
Resveratrol and Serum Apo A-I
Although much effort has been done to lower LDL-cholesterol concentrations, there is still a substantial risk for cardiovascular disease (CVD). Another strategy to lower the risk for CVD is elevating the HDL-cholesterol (HDL-C).
- Trial name
- NCT01364961
- Testing
- Resveratrol capsules
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Balance Disorders, Accidental Falls
Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People
As people age, it becomes more common to experience balance problems. These issues can increase the risk of falling, which may lead to serious health consequences and loss of independence.
- Conditions
- Balance Disorders, Accidental Falls, Frailty, Aging
- Trial name
- EPIBAS (NCT06965660)
- Where
- Spain
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Myopia
Optical Coherence Tomography Angiography in Myopic Patients
The aim of this study is to investigate the macular microvascular network alterations in high myopic eyes using optical coherence tomography angiography.
- Trial name
- NCT04135209
- Testing
- Optical coherence tomography angiography OCTA
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Minia University
Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography
Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes With Exudative Circumscribed Choroidal Haemangioma: An Optical Coherence Tomography Angiography Study
The study aims to quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma using optical coherence tomography angiography.
- Conditions
- Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography, Macular
- Trial name
- NCT04449900
- Testing
- This is observational study with the examination of OCTA
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Patients With Primary Nasal Pterygium
Effects of Ranibizumab in Primary Pterygium Surgery
Pterygium is a common ocular surface disease in Malaysia. Without treatment, it can lead to severe visual impairment. Recurrence is the commonest complication and novel treatment approaches are crucial to prevent vision loss.
- Trial name
- NCT04878835
- Testing
- intralesional ranibizumab
- Where
- Malaysia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Autosomal Dominant Polycystic Kidney Disease
Intrarenal Microvasculature in ADPKD
The primary objective of this study is to evaluate the use of Super-resolution ultrasound (SRU) to assess the intrarenal microvasculature in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and healthy…
- Trial name
- NCT05288998
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic