Clinical trials: Middle Cerebral Artery Stroke
Infarction, Anterior Cerebral Artery, Infarction, Middle Cerebral Artery
An Observational Registry Study of LUOTAI in Patients With Acute Ischemic Stroke in Vietnam
Ischemic stroke occurs when an artery to the brain is blocked. If the artery remains blocked for more than a few minutes, the brain cells may die. This is why immediate medical treatment is critical.
- Conditions
- Infarction, Anterior Cerebral Artery, Infarction, Middle Cerebral Artery, Ischemic Attack, Transient
- Trial name
- NCT03679364
- Where
- 3 sites in Vietnam
- Volunteers
- 364 people
- Sponsor
- KPC Pharmaceuticals, Inc
Middle Cerebral Artery Infarction, Anterior Cerebral Artery Infarction
Stem Cell Therapy For Acute Ischemic Stroke Patients
The purpose of this study is to determine whether patients with subacute ischemic stroke will benefit from infusion of patient's own bone marrow derived stem cells.
- Trial name
- InVeST (NCT02425670)
- Testing
- BMSCs
- Where
- 5 sites in India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke
Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke
The purpose of this randomized, double-blind, placebo-controlled multicenter study is to determine in a cohort of 506 patients with acute ischemic stroke in the middle cerebral artery territory, the effect of a three-day…
- Conditions
- Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke, Stroke, Acute
- Trial name
- ESS (NCT00604630)
- Testing
- recombinant human erythropoietin alfa, 0.9% NaCl
- Where
- 9 sites in Germany
- Volunteers
- 522 people
- Sponsor
- Max-Planck-Institute of Experimental Medicine
Acute Stroke
tDCS in Acute Stroke Patients
Very early after the onset of the focal perfusion deficit, excitotoxic mechanisms can lethally damage neurons and glia. Excitotoxicity triggers a number of events that can further contribute to tissue death.
- Trial name
- tDCS (NCT02806856)
- Testing
- tDCS neuroConn
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Stroke, Acute Ischemic
Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION)
The mortality of malignant middle cerebral artery infarction (mMCAI) is up to 80%, while current available treatment is limited.
- Trial name
- NCT05849805
- Testing
- Intracalvaria bone marrow injection, Conventional treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disease
Tissue Kallikrein Preventing the Restenosis After Stenting of Symptomatic MCA Atherosclerotic Stenosis
The study aims to determine whether tissue kallikrein (TK) is efficacy for preventing the long-term in-stent restenosis (ISR) after stenting of symptomatic atherosclerotic stenosis of the middle cerebral artery (MCA) M1 segment
- Trial name
- NCT01558245
- Testing
- tissue kallikrein
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Jinling Hospital, China
Middle Cerebral Artery Infarction
Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery
Malignant middle cerebral artery infarction(MMCI) has a high rate of disability and mortality. At present, there is no effective treatment except for craniotomy decompression, but the controversy of the craniotomy decompression…
- Trial name
- SMART (NCT02609256)
- Testing
- Stereotactic infarct tissue aspiration, Medical therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- General Hospital of Shenyang Military Region
Endovascular Therapy, Acute Ischemic Stroke
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
RESCUE-M2O trial is a prospective, open label, blinded endpoint (PROBE), two-arm, randomized, controlled, post-market study to assess the efficacy and safety of endovascular therapy for acute ischemic stroke with occlusion of the…
- Conditions
- Endovascular Therapy, Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
- Trial name
- NCT07347665
- Testing
- Endovascular therapy
- Where
- 3 sites in Japan, Thailand and 1 more
- Volunteers
- 200 people
- Sponsor
- Hyogo Medical University
Stroke, Middle Cerebral Artery Infarction
Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients
The objective of the study is to determine the efficacy of brain transplants of CD34+ stem cells obtained from peripheral blood of patients in the treatment of chronic stroke patients.
- Trial name
- NCT00950521
- Testing
- Intercerebral implantation of Autulogous Stem Cells, convention therapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Stroke, Acute, Stroke, Ischemic
Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial
The objective of the MEDIS study is to determine if subjects experiencing an Acute Ischaemic Stroke due to large vessel occlusion, treated with IV tPA combined with the MED procedure have a greater likelihood of recanalisation…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Infarction, Middle Cerebral Artery, Strokes Thrombotic
- Trial name
- MEDIS (NCT03098732)
- Testing
- Magnetically Enhanced Diffusion (MED)
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Pulse Therapeutics
Middle Cerebral Artery Infarction
Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct
This study aims to determine the efficacy of intravenous transplantation of autologous bone marrow-derived mesenchymal stem cells in patients with acute middle cerebral artery infarct.
- Trial name
- NCT01461720
- Testing
- Standard medical care, Autologous bone marrow-derived mesenchymal stem cells
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Middle Cerebral Artery Stroke
Post-stroke Epilepsy: Primary Prophylaxis Study
Advance in stroke treatment have resulted in a dramatic reduction in the stroke mortality, however, the number of stroke survivors living with morbidity has increased significantly.
- Trial name
- NCT04858841
- Testing
- Levetiracetam Oral Product, Perampanel Oral Product
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Cheng Kung University
Middle Cerebral Artery Occlusion With Cerebral Infarction
The AGAINST Protocol: Augmentative Craniotomy in Stroke
Malignant Middle Cerebral Artery (MCA) infarction is a term used for the severe clinical and neurological hemispheric syndrome caused by ischemic occlusion of the proximal tract of MCA and it is observed in near the 10% of all…
- Trial name
- AGAINST (NCT05860855)
- Testing
- Augmentative craniotomy, Decompressive craniotomy
- Volunteers
- 70 people
- Sponsor
- University of Roma La Sapienza
Cognitive Recovery After Stroke, Cognitive Outcome After Stroke
Long-Term Cognitive Recovery After Arteria Cerebri Media Ischemia: A Digital Assessment Using the TuCAN-App
TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale [mRS] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral…
- Trial name
- TuCAN-Media (NCT07885189)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Infarction, Middle Cerebral Artery
Thrombectomy Under Reopro Versus Alteplase to Treat Stoke
Intravenous (IV) Alteplase (rt-PA) is the gold standard for brain infarction within 4 h 30 of symptoms onset. Efficacy of this therapy is limited in the setting of large artery occlusions.
- Trial name
- TURANDOT (NCT02016547)
- Testing
- abciximab IV and thrombectomy, alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- SOS Attaque Cérébrale
Intracranial Embolism, Thrombosis
Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
The purpose of the present, randomized, controlled multicenter phase III trial is to investigate the safety and efficacy of continuous 1-hour insonation of occluded middle cerebral artery with 2 MHz TCCS in stroke patients…
- Trial name
- NCT00336596
- Testing
- transcranial ultrasound in patients treated with iv t-PA
- Where
- 6 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Stroke, Acute
aICP Measurement in Patients With Cerebral Artery Infarction / aICP MCA Infarction
Space-occupying, malignant middle cerebral artery (M-MCA) infarctions are still one of the most devastating forms of ischemic stroke, with a mortality of up to 80% in untreated patients.
- Trial name
- aICPStroke (NCT03641963)
- Testing
- Vittamed 205 Non-invasive intracranial pressure (ICP) meter
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Kantonsspital Aarau
Malignant Middle Cerebral Artery Infarction
Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts
The purpose of this study is to determine if patients with malignant middle cerebral artery infarction have a better clinical outcome after early decompressive surgery compared to standard medical management.
- Trial name
- DECIMAL (NCT00190203)
- Testing
- Decompressive hemicraniectomy and duraplasty, hemicraniectomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aphasia
Effect of Music on Reading Comprehension in Patients With Aphasia
The purpose of this investigation is to examine the evidence on emotion, language, and music, and propose a first step, in the form of a single-subject research design, to determine the most effective and efficient method for…
- Trial name
- NCT03600987
- Testing
- Simultaneous music and reading lyrics, Priming with music, Control
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Carilion Clinic
Cerebrovascular Occlusion, Collateral Blood Circulation
The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion
Stroke is the first leading cause of death in China, and is responsible for almost 22.4% of deaths. In approximately 80% of cases stroke is ischaemic, i.e.
- Conditions
- Cerebrovascular Occlusion, Collateral Blood Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- INCIMO (NCT02594995)
- Testing
- NBP
- Where
- China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine