Clinical trials: Middle Ear Disease
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Middle Ear Disease
Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts
Prospectively analyze the use of 3D subtraction CAD/CAM in the operating room environment. Study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants.
- Trial name
- NCT03297736
- Testing
- 3D CAD/CAM autograft prosthesis, Control device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nitinetics LLC
Eustachian Tube Dysfunction
Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction
The aim of this study is to determine which of the many Eustachian tube function tests (or combination of tests) is most helpful in finding out what is causing ear problems in children and adult patients with middle-ear diseases…
- Trial name
- NCT01974726
- Testing
- ET Stress test, Sonotubometry, Forced Response Test (FRT)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Middle Ear Disease
Optical Coherence Tomography of the Middle Ear Using Ossiview
The aim of this study is to understand the diagnostic applications for this imaging technology and identify particular disorders to target for future clinical investigations.
- Trial name
- NCT05085379
- Testing
- Ossiview
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arkansas
Adenoid Hypertrophy, Middle Ear Effusion
It is Accepted That Adenoid Hypertrophy is Related to Otitis Media With Effusion Incidence. Better Understanding of the Correlation Between the Relative Size of AH and the Incidence of Persistent OME May Provide Evidence to Support a More Standardized Approach to the Diagnosis and Treatment of OME.
The aim of this study is to further investigate the correlation between Site and size of adenoid hypertrophy and middle ear effusion in order to provide evidence for designing a more standardized approach to the diagnosis and…
- Trial name
- NCT06674720
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Middle-ear Function
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3
This is a study to determine if there are reflexes that detect changes in eardrum position or in the pressure of middle-ear gases and respond with changes in the ease by which the Eustachian tube is opened.
- Trial name
- NCT01925495
- Testing
- varied middle-ear pressure, varied middle-ear gas composition, varied ear-canal pressure
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cuneyt M. Alper
Upper Respiratory Infection, Acute Otitis Media
Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil
The purpose of this study is to evaluate the effect of oral administration of probiotic Lactobacillus rhamnosus GG in middle ear and adenoid tonsil.
- Trial name
- NCT02110732
- Testing
- Lactobacillus rhamnosus GG
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Hearing Disorders
Middle-ear Reflex Testing Using Wideband Acoustic Immittance
This project will assess the middle-ear muscle reflex using wideband acoustic immittance which is a valuable method for evaluating infants, children, and adults.
- Trial name
- WAI-MEMR (NCT04875637)
- Testing
- WAI-MEMR
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Mimosa Acoustics
Otitis Media
Vaccination for Middle Ear Infection
Acute otitis media (OM) and OM with effusion are common childhood diseases. Otitis media is a condition marked by inflammation of the middle ear.
- Trial name
- NCT00001605
- Testing
- Nontypeable Haemophilus influenzae
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Eustachian Tube Dysfunction, Hearing Disorders
FFP3 Respirators and Ears - Effects on Middle Ear Pressure and Hearing
This is Prospective Basic Science Study whose aims are as follows: 1. To determine the effect of Filtering Facepiece (FFP3M) respirators on eustachian tube function and hearing 2.
- Conditions
- Eustachian Tube Dysfunction, Hearing Disorders, Nasal Obstruction
- Trial name
- FFP3-RAE (NCT05222230)
- Testing
- FFP3 Mask
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Otitis Media, Middle Ear Effusion
Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11
Middle-ear disease (infection and fluid) is the most common illness in young children after the common cold. Because hearing loss accompanies middle-ear disease, and because early life is a period of rapid development, concern…
- Trial name
- NCT00365092
- Testing
- Insertion of tympanostomy tubes
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dementia, Hearing Loss
Hearing Impairment as a Risk Factor for Dementia in Older Adults
This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby…
- Trial name
- NCT04284384
- Where
- Norway
- Volunteers
- 6,952 people, healthy volunteers welcome
- Sponsor
- Norwegian Centre for Ageing and Health
Middle Ear Disease
The Effect of Tranexamic Acid in Endoscopic and Microscopic Ear Surgery Cases on Surgeon Satisfaction
By using tranexamic acid, an antifibrinolytic drug, the aim is to prevent the restriction of the field of view of the surgical field due to bleeding in middle ear microscopic and endoscopic surgery operations in which controlled…
- Trial name
- NCT06434636
- Testing
- Transamine 10% IV/IM Solution for Injection, %0.9 Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c
This study will determine if gas can pass between the environment and the middle ear by way of the eardrum. This route of gas exchange was observed in animals but has not been studied in humans.
- Trial name
- NCT00422851
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Otitis Media With Effusion
Wideband Tympanometry in Otitis Media With Effusion
The investigators asked the question if they can better estimate the middle ear status in OME that help them to decide between early intervention or longer follow up.
- Trial name
- NCT04395261
- Testing
- Wideband Tympanometry
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Healthy
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3a Part ii
The middle ear is an airspace located behind the eardrum that consists of two connecting compartments. The compartment directly behind the eardrum is called the tympanum and contains the three small bones of the middle ear, the…
- Trial name
- NCT00494364
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Otitis
Eustachian Tube Testing in a Pressure Chamber -- Validation Study
This study will compare Eustachian tube function (ETF) testing in adults with intact tympanic membranes (TM) using a pressure chamber to that obtained using standard methods requiring a non-intact TM.
- Trial name
- NCT00694486
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Ear Infection, Middle Ear Infection
Diagnostic Utility of Otosight Middle Ear Scope
Evaluate clinic workflow impact of OtoSight use for patients seen in the pediatric otolaryngology clinic.
- Conditions
- Ear Infection, Middle Ear Infection, Otitis Media
- Trial name
- NCT05641285
- Testing
- The OtoSight Middle Ear Scope
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Disorder of Middle Ear, Otosclerosis of Middle Ear
Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Feasibility of the objective measurement of the ossicular chain mobility, by using a force-measuring device based on a fiber optics sensors (PalpEar).
- Conditions
- Disorder of Middle Ear, Otosclerosis of Middle Ear, Cholesteatoma, Middle Ear
- Trial name
- PalpEar (NCT02554422)
- Testing
- PalpEar
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sensoptic SA
Eustachian Tube Disorder
Evaluating Changes in Middle Ear Pressure Caused by CPAP
This study is an investigation into the effect that CPAP has on the pressure in the middle ear. It will evaluate the middle ear pressure and ear drum appearance at multiple levels of CPAP pressure delivered via a full face mask.
- Trial name
- NCT02882022
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia