Clinical trials: Mifepristone
Abortion, Induced
Termination of Pregnancy With Mifepristone and Misoprostol Versus Sulprostone
The purpose of this study is to determine which medical treatment is the most effective to terminate a pregnancy.
- Trial name
- NCT00206193
- Testing
- mifepristone, misoprostol, sulprostone
- Where
- Netherlands
- Sponsor
- Atrium Medical Center
Major Depressive Disorder
An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00146523
- Testing
- Mifepristone
- Where
- 19 sites in Bulgaria, Croatia and 2 more
- Volunteers
- 247 people
- Sponsor
- Corcept Therapeutics
BRCA1 Mutation, High-grade Serous Ovarian Cancer
Breast Cancer BRCA1 Carriers: a Pilot Study
The purpose of this study is to examine how a single dose of MIFEPREX® (mifepristone) affects the breast tissue in patients with BRCA1 (a gene that normally acts to restrain the growth of cells in the breast, but if it mutates…
- Conditions
- BRCA1 Mutation, High-grade Serous Ovarian Cancer, TNBC - Triple-Negative Breast Cancer
- Trial name
- NCT05062174
- Testing
- Mifepristone 200 MG, Prophylactic mastectomy
- Where
- 2 sites in United States
- Sponsor
- Indiana University
Female Contraception
Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small.
- Trial name
- WOMEN&More (NCT06394999)
- Testing
- Mifepristone 50 mg
- Where
- 14 sites in Netherlands
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Alzheimer's Disease
Mifepristone as Adjunctive Therapy in Alzheimer's Disease
The purpose of this study is to evaluate the effects of C-1073 (Mifepristone) on cognition in patients with Alzheimer's disease (AD) who are also taking an acetylcholinesterase inhibitor (Aricept, Exelon or Reminyl).
- Trial name
- NCT00105105
- Testing
- Mifepristone
- Where
- 21 sites in United States
- Volunteers
- 160 people
- Sponsor
- Corcept Therapeutics
Cortisol Resistance, Negative Feedback
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.
- Conditions
- Cortisol Resistance, Negative Feedback, ACTH, Mineralcorticoid
- Trial name
- NCT01294319
- Testing
- Mifepristone, Spironolactone, Combined
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Medical; Abortion, Fetus
Mifepristone and Misoprostol for the Termination of Pregnancy up to 70 Days Gestation
The purpose of this study is to determine the efficacy and acceptability of a regimen of 200 mg mifepristone (Zacafemyl), followed 24-48 hours later by 800 mcg of buccal misoprostol.
- Trial name
- NCT01966874
- Where
- United States
- Volunteers
- 1,001 people
- Sponsor
- Gynuity Health Projects
Endocrine Disease, Diabetes
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
Background: Metabolic syndrome is a name given to a group of factors that tend to occur together. These risk factors include central obesity (extra weight around the middle of the body) and high blood pressure and blood sugar…
- Trial name
- NCT01419535
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Labor; Forced or Induced, Affecting Fetus or Newborn, Labor Onset and Length Abnormalities
Clinical Evaluation of Cervical Ripening in the Outpatient Setting
A randomized controlled trial of mifepristone 200mg vs balloon catheter for cervical ripening.
- Trial name
- NCT04271722
- Testing
- Cervical ripening
- Where
- Portugal
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Breast Cancer
Abraxane® With or Without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer
This is a randomized, placebo-controlled, double-blind, phase II trial of nab-paclitaxel with or without mifepristone for advanced, glucocorticoid receptor-positive, triple-negative breast cancer.
- Trial name
- NCT02788981
- Testing
- Mifepristone, Nab-Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Chicago
Gulf War Illness
TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset
Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances…
- Trial name
- E/M (NCT04254627)
- Testing
- Etanercept, Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Nova Southeastern University
Termination of Pregnancy Second Trimester
Misoprostol for Second Trimester Termination of Pregnancy
To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.
- Trial name
- MIMIS (NCT00945997)
- Testing
- misoprostol
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Male Breast Cancer, Recurrent Breast Cancer
Nab-paclitaxel (Abraxane) With or Without Mifepristone in Patients With Advanced Breast Cancer
This trial will find the best dose of mifepristone when given together with nab-paclitaxel (Abraxane) based on the side effects of the two drugs in patients with advanced breast cancer.
- Conditions
- Male Breast Cancer, Recurrent Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT01493310
- Testing
- mifepristone, nab-paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Chicago
Abortion in First Trimester
The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy
Medical termination of pregnancy (mTOP) generally involves using either a combined regimen consisting of mifepristone and misoprostol, or a misoprostol-only regimen.
- Trial name
- NCT05341817
- Testing
- Letrozole, Mifepristone
- Where
- Singapore
- Volunteers
- 144 people
- Sponsor
- KK Women's and Children's Hospital
Medical Abortion
De-Medicalizing Mifepristone Medical Abortion
This study will investigate the possibility that medical abortion using mifepristone and misoprostol - a safe, proven therapy for terminating early first trimester pregnancy - can be administered in a manner that is simpler and…
- Trial name
- NCT00120224
- Where
- 3 sites in United States
- Volunteers
- 4,410 people
- Sponsor
- Gynuity Health Projects
Miscarriage
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol…
- Trial name
- NCT05304273
- Testing
- Mifepristone, Letrozole
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Calcutta National Medical College and Hospital
Induced Abortion
Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation
This open-label, randomized study is being conducted to determine whether a dose of 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and…
- Trial name
- NCT00286208
- Testing
- Mifepristone, misoprostol
- Where
- 9 sites in Moldova, Tunisia and 1 more
- Volunteers
- 1,443 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
HIV Infections
Anti-HIV Activity and Safety of 3 Different Doses of Mifepristone in HIV Infected People
The purpose of this study is to determine the anti-HIV activity and safety of 3 different doses of mifepristone (also known as VGX-410 and RU486) in HIV infected people.
- Trial name
- NCT00099645
- Testing
- Mifepristone
- Where
- 10 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Central Adrenal Insufficiency, Mifepristone
Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency
The researchers propose the use of mifepristone as an alternative way to test for Central Adrenal Insufficiency (CAI). They want to assess the feasibility of recruitment and the efficacy of the purposed method.
- Trial name
- NCT04588688
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Tobias Else
Medical Abortion
Effectiveness and Safety of Combination Mifepristone/Misoprostol for Medical Abortion
National multi-center non interventional study aiming at investigating the effectiveness and safety of the combination mifepristone-misoprostol prescribed in Canada to women for medical termination of pregnancy at or before 63…
- Trial name
- MiMAC (NCT04905251)
- Testing
- Mifepristone-Misoprostol
- Where
- 6 sites in Canada
- Volunteers
- 129 people
- Sponsor
- Linepharma International LTD