Clinical trials: Mild Cognitive Disorder
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Impairment, Alzheimer Disease
Validation of a Smartphone Application for the Assessment of Patients With Mild Cognitive Impairment: MemScreen
The clinical evaluation of a patient with a cognitive complaint requires neuropsychological tests, evaluating the integrity of memory and other cognitive functions.
- Trial name
- MemScreen (NCT03811184)
- Testing
- MemScreen
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MemScreen
Mild Dementia, Moderate Dementia
The Effects of a Park Visit Program on Individuals With Dementia and Their Caregivers
The overall goals of our project is to understand the effects of participating in park visits and nature-based activities for people living with dementia and their caregivers.
- Conditions
- Mild Dementia, Moderate Dementia, Alzheimer Disease
- Trial name
- NCT05527587
- Testing
- Nature Connections Intervention
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Mild Cognitive Impairment
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)
With the growing burden of dementia (including Alzheimer's disease), and the lack of efficacious therapies, there is an urgent need to identify new therapeutics.
- Trial name
- NCT03641404
- Testing
- L-ergothioneine
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Alzheimer Disease, Healthy Aging
Amyloid Imaging With 11C-PiB in Healthy Aging and Mild Cognitive Impairment
The purpose of this study is to measure the amount of amyloid in the brain. Amyloid is a protein found in the brain of patients with Alzheimer's disease and can be detected using a Positron Emission Tomography (PET) scan.
- Trial name
- NCT04505735
- Testing
- 11C-PiB
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment (MCI), Geriatric
Investigation of Different Rehabilitation Approaches in Older Adults With Mild Cognitive Impairment
This randomized controlled trial aims to comparatively examine whether cognitive training and hand exercise training provided to older adults with mild cognitive impairment (MCI) have an impact on their cognitive functions, hand…
- Trial name
- NCT06837493
- Testing
- Resistance based hand exercises and functional task-oriented hand exercise, Cognitive training
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Uşak University
Memory Disturbances
Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function
The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic…
- Trial name
- NCT01873664
- Testing
- Jaw-tapping
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Mild Cognitive Impairment, Alzheimer Disease
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- SMART (NCT05877196)
- Testing
- Moderate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Mild Cognitive Impairment
The Effect of Growth Hormone Releasing Hormone on Cognitive Function in Individuals With Mild Cognitive Impairment
This study is examining the effects of growth hormone releasing hormone (GHRH) on mild cognitive impairment (MCI). GHRH will be given at a dose of 1mg/day for 10 weeks to subjects with MCI as well as healthy controls.
- Trial name
- NCT02553603
- Testing
- Growth Hormone Releasing Hormone (GHRH)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes Mellitus Type 2, Mild Cognitive Impairment
The Early Warning System for the Diabetic Encephalopathy
Diabetes( mainly type II diabetes )lead to the central nervous system (CNS) function impairment, especially the mild cognitive impairment that increased the risk of progression to dementia.The primary objectives are defined…
- Conditions
- Diabetes Mellitus Type 2, Mild Cognitive Impairment, Metabolic Syndrome X
- Trial name
- NCT02420470
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Mild Cognitive Impairment, Dementia
SCGs as a Proxy for Determining the Cognitive Status of Older Adults
Detecting memory problems early is crucial for treating conditions like Mild Cognitive Impairment (MCI), which often leads to dementia. Currently, doctors use tests in clinics to check for these issues.
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer Disease, Healthy Aging
- Trial name
- NCT06367231
- Testing
- VibrantMinds
- Where
- 8 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Alzheimer Disease, Cognitive Impairment
Biomarker Exploration in Aging, Cognition and Neurodegeneration
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- BEACoN (NCT03860857)
- Testing
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Mild Cognitive Impairment
Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease
This is a single center imaging study that will recruit 60 participants who are enrolled in the Effect of a Ketogenic Diet on Alzheimer's Disease Biomarkers and Symptoms: Brain Energy for Amyloid Transformation in AD (BEAT-AD)…
- Trial name
- AcAc PET (NCT03130036)
- Testing
- [11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
Preoperative Cognitive Screening of Surgical Patients 65 Years of Age or Older
The overall objectives of this study are to improve outcomes of surgical patients 65 years of age or older through risk stratification based on preoperative screening of cognition / mental function.
- Trial name
- NCT02570451
- Testing
- Patient Survey, Mini Cog, Independent Activities of Daily Living Score Sheet
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Cognitive Impairment, Alzheimer's Disease
Multi-modality MRI Study on Prediction for Mild Cognitive Impairment Conversion
The purpose of this study is to find the characteristics of mild cognitive impairment (MCI) using technology of Multi-Modality MRI , including structural MRI, functional MRI and diffusion tensor imaging(DTI).
- Trial name
- NCT02353884
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- XuanwuH 2
Mild Cognitive Impairment
Comparison of the Effects of Bimanual, Finger and VR Exercises in PwMCI
Mild Cognitive Impairment (MCI) is defined as an impairment in a single cognitive function, usually memory, other than normal cognitive decline with age, that does not fulfil dementia criteria.
- Trial name
- NCT06935812
- Testing
- Bimanual Exercise, Finger Exercise, Virtual Reality
- Where
- Cyprus
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
Alzheimer's Disease Neuroimaging Initiative 3
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD.
- Trial name
- ADNI3 (NCT02854033)
- Where
- 59 sites in United States, Canada
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Mild Cognitive Impairment, Alzheimer Disease
Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's Disease
This study will perform a targeted metabolic analysis in blood and urine samples from subjects attending the Baylor AT\&T Memory Center.
- Trial name
- BVB (NCT03136679)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute