Clinical trials: Mild Stroke
Ischemic Stroke
Mild and Rapidly Improving Stroke Study
The objective of this study is to determine the 90-day outcomes of mild and rapidly improving ischemic stroke.
- Trial name
- MaRISS (NCT02072681)
- Where
- 97 sites in United States
- Volunteers
- 2,175 people
- Sponsor
- University of Miami
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Stroke
Virtual Reality Training Program for Ambulatory Patients With Chronic Gait Deficits After Stroke
The purpose of this study is to examine the feasibility and efficacy of a virtual reality program for ambulatory patients with mild-to-moderate chronic gait deficits after stroke.
- Trial name
- NCT00600379
- Testing
- Virtual reality system (CAREN™ Integrated Reality System; MOTEK BV, Netherlands).
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Sheba Medical Center
Stroke Patients With Cognitive Decline
Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline
The purposes are to: (1) examine and compare the effects of two hybrid interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive and physical functions, from pre- to post-training…
- Trial name
- NCT03230253
- Testing
- Sequential training, Dual training, Control training
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Ischemic Stroke
Mild Acute Ischemic Stroke With Large Vessel Occlusion (MISTWAVE)
Stroke remains the leading cause of disability in the United States. An estimated 40-50% of all ischemic strokes are caused by large-vessel occlusion of a major cerebral artery (LVO).
- Trial name
- MISTWAVE (NCT03731351)
- Testing
- Mechanical Thrombectomy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Stroke
Study of Cognitive-Linguistic Profiles: The Role of Executive Control in Aphasia
In France, stroke affects 150,000 people annually and is the leading cause of acquired disability in adults; 10-12% of patients exhibit mild post-stroke aphasia, a condition defined by language difficulties.
- Trial name
- P-CLAC (NCT07766356)
- Testing
- Neuropsychological tests, Speech-language assessments
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Cognitive Impairment, Stroke
Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory.
- Conditions
- Cognitive Impairment, Stroke, Albumin; Double
- Trial name
- NCT04135872
- Testing
- strengthened nuitritional treatment
- Where
- China
- Volunteers
- 435 people
- Sponsor
- Dongguan People's Hospital
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, PFA Ablation and LAAC Procedures
Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk
This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in…
- Trial name
- REVERSE-OPTION (NCT07453940)
- Testing
- LAAC plus PFA for persistent AF with high risk of stroke, LAAC for persistent AF with high risk of stroke
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Stroke
Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke
Acute ischemic stroke (AIS) is one of common diseases with significant morbidity, mortality and disability. A wide array of studies confirms that intravenous thrombolytic therapy with alteplase can effectively improve the…
- Trial name
- ARAMIS (NCT03661411)
- Testing
- Aspirin, Clopidogrel 75mg, Alteplase
- Where
- China
- Volunteers
- 760 people
- Sponsor
- General Hospital of Shenyang Military Region
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Stroke, Amyotrophic Lateral Sclerosis
Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation
This interventional, multicenter, low-intervention clinical trial aims to evaluate the usability, feasibility, safety, and preliminary clinical impact of a robotic rehabilitation system designed for upper limb rehabilitation in…
- Conditions
- Stroke, Amyotrophic Lateral Sclerosis, PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
- Trial name
- ASULDAR (NCT07636538)
- Testing
- Auto-calibrating System for Upper Limb disability Assessment, neurological and occupational Rehabilitation, conventional therapy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Stroke, Mild Cognitive Impairment
Investigating Neurocognitive, Motor and Biological Effects of MindLenses Professional in Neurological Diseases
This study aims to explore the effects of the treatment with MindLenses Professional device on cognitive and motor performances,as well as on the levels of a neurotrophic factor implied in brain plasticity, that is the brain…
- Trial name
- MindLensesN (NCT05826626)
- Testing
- MindLenses Professional, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Right Hemispheric Stroke, Left Hemispheric Stroke
Neural and Cognitive Correlates of Pragmatic Abilities
Pragmatics of language refers to the set of abilities that allow one to use and interpret language according to context and, in general, to communicate effectively.
- Conditions
- Right Hemispheric Stroke, Left Hemispheric Stroke, Traumatic Brain Injury, Right Hemispheric Brain Tumor
- Trial name
- APACS_Neuro (NCT06297044)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke, Acute
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM (NCT01585597)
- Testing
- Zoll- Coolgaurd 3000
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Stroke, Ischemic, Cerebrovascular; Disorder, Occlusive
Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion
Endovascular therapy (EVT) added on best medical management is currently recommended in acute large vascular occlusion (LVO) stroke patients with National Institutes of Health Stroke Scale (NIHSS) score >5.
- Trial name
- NCT06155032
- Testing
- Endovascular therapy, Best medical management
- Where
- 7 sites in China
- Volunteers
- 272 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Stroke, Mild Cognitive Impairment
Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes
The trial was designed to test the hypothesis that early treatment with nimodipine has a positive effect on cognition impairment after acute ischemic stroke.
- Trial name
- NICE (NCT01220622)
- Testing
- Nimodipine
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Brain Tumors, Epilepsy
Quality Improvement and Practice Based Research in Neurology Using the EMR
The investigators will conduct at NorthShore University HealthSystem pragmatic trials using the EMR for 10 common neurological disorders.
- Conditions
- Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment
- Trial name
- NCT02670161
- Testing
- Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Endeavor Health
Stroke
Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
- Trial name
- TIME-MINOR (NCT07476898)
- Testing
- Tenecteplase (0.25mg/kg), Standard Medical Management
- Where
- 30 sites in China
- Volunteers
- 864 people
- Sponsor
- First Hospital of China Medical University
Stroke, Mild Cognitive Impairment (MCI)
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment (MCI), Vestibular Disease, Long Covid-19
- Trial name
- TeleRehab DSS (NCT07079787)
- Testing
- TeleRehab DSS Pilot Test
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 30 people
- Sponsor
- University College, London