Clinical trials: Minimal Hepatic Encephalopathy
Minimal Hepatic Encephalopathy
Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy
Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact. Thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected…
- Trial name
- NCT04077125
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Cirrhoses, Hepatic Encephalopathy
Role of MRI in Detection of Minimal Hepatic Encephalopathy
Introduction Liver cirrhosis (LC) is irreversible fibrosis of the liver (1) and it remains a public health problem. One of the complications of the cirrhosis is hepatic encephalopathy (HE) which is defined as brain dysfunction…
- Trial name
- NCT04131205
- Testing
- Magnetic Resonance Imaging
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hepatic Encephalopathy, Cirrhosis
Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106)
Hepatic encephalopathy (HE) is a common complication of cirrhosis, which seriously damages the life quality of patients. As the disease progresses, 50-80% of patients with cirrhosis develop HE.
- Trial name
- NCT05140837
- Testing
- Psychometric hepatic encephalopathy score & Stroop test, Drug therapy
- Where
- 31 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Liver Cirrhosis, Hepatic Encephalopathy
Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
The investigators wish to investigate how the Continuous Reaction Time (CRT) method can be used in the diagnosis and monitoring of covert hepatic encephalopathy (cHE)in patients with cirrhosis of the liver.
- Trial name
- NCT01773538
- Testing
- Lactulose and rifaximin, Branched Chain amino acids
- Where
- 2 sites in Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Mette Munk Lauridsen
Minimal Hepatic Encephalopathy
Antioxidants and Zinc Improving Minimal Hepatic Encephalopathy In Truck Drivers; a Pilot Study
Minimal hepatic encephalopathy (MHE) can have a far-reaching impact on quality and ability to function in daily life and may progress to overt Hepatic Encephalopathy.
- Trial name
- NCT02520817
- Testing
- 175 mg zinc gluconate, 50000 IU vitamin A, 500 mg vitamin C and 100 mg vitamin E once daily plus lactulose; dose 30-60 ml/day for 3 months, Lactulose
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy
Purpose Hepatic encephalopathy (HE) is a serious complication of liver cirrhosis that can cause memory loss, slow reaction, and even coma.
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Liver Cirrhosis
- Trial name
- NCT07612670
- Testing
- wechat mini-program
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Study of MHE in Patients With Liver Diseases
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on…
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Overt Hepatic Encephalopathy
- Trial name
- NCT04058327
- Testing
- neurophysiological tests, blood biomarkers.
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Qin Ning
Minimal Hepatic Encephalopathy
Psychometric Hepatic Encephalopathy Score in Prediction of Minimal Hepatic Encephalopathy in Compensated Cirrhotic Patients
Minimal hepatic encephalopathy (MHE) is a covert form of hepatic encephalopathy associated with cognitive and psychomotor impairment in patients with compensated liver cirrhosis.
- Trial name
- PHES-MHE (NCT07272707)
- Testing
- Psychometric Hepatic Encephalopathy Score (PHES)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Depression in Chronic Hepatitis C
Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Minimal hepatic encephalopathy (MHE) is an important clinical variant of hepatic encephalopathy (HE), which occurs in up to 60-70% of patients with cirrhosis.
- Trial name
- NCT04330508
- Testing
- Depression and Cognitive Tests
- Where
- India
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Minimal Hepatic Encephalopathy
Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation
This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls…
- Trial name
- NCT02767622
- Testing
- Liver transplantation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hepatic Encephalopathy, Liver Cirrhosis
Diagnosing Minimal Hepatic Encephalopathy
Our purpose is to 1. Examine the correlation between MDF in a resting EEG, recorded just before the CRT test, and the variance in reaction times indicated by the CRT index 2.
- Trial name
- MindTheLiver (NCT05433948)
- Testing
- Simultaneous EEG and CRT
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Liver Cirrhosis, Hepatic Encephalopathy
Electronic PHES vs Paper-based PHES for Hepatic Encephalopathy
This is a prospective, multicenter, randomized crossover diagnostic accuracy study. A total of 80 patients with liver cirrhosis will be enrolled and randomly assigned to two sequence groups at a 1:1 ratio.
- Conditions
- Liver Cirrhosis, Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
- Trial name
- NCT07852416
- Testing
- Paper-based Psychometric Hepatic Encephalopathy Score (PHES), Electronic Psychometric Hepatic Encephalopathy Score (PHES)
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University