Clinical trials: Minimum Effective Dose
Postoperative Ileus
Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery
The purpose of this study is to determine whether TZP-101 is effective in the management of post operative ileus in subjects undergoing major open abdominal surgery (i.e. partial large bowel resection).
- Trial name
- NCT00617552
- Testing
- 5% dextrose in water, TZP-101
- Where
- 27 sites in United States, India and 1 more
- Volunteers
- 267 people
- Sponsor
- Tranzyme, Inc.
Postoperative Pain
Effect of Preemptive Intramuscular Diclofenac on Minimal Effective-Dose Bupivacaine Saddle Block for Minor Perianal Surgeries
The research will be carried out in order to test the effect of Intramuscular (IM) Diclofenac, administered as preemptive analgesic with minimal effective dose spinal anesthesia in perianal surgeries, on prolonging the time to…
- Trial name
- NCT04849468
- Testing
- Declofenac, saline
- Where
- Saudi Arabia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Chemotherapy-Induced Nausea and Vomiting
An Efficacy and Safety Study of Intravenous Palonosetron Administered as an Infusion and as a Bolus for the Prevention of Nausea and Vomiting
PALO-15-17 is a clinical study assessing efficacy and safety of a single dose of palonosetron 0.25 mg administered as a 30-minute IV infusion compared to palonosetron 0.25 mg administered as a 30-second IV bolus (Aloxi, an…
- Trial name
- NCT02557035
- Testing
- Palonosetron, Dexamethasone
- Where
- 76 sites in Belarus, Bosnia and Herzegovina and 7 more
- Volunteers
- 441 people
- Sponsor
- Helsinn Healthcare SA
Veno-occlusive Disease
Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell Transplantation
RATIONALE: Giving defibrotide may be an effective treatment for liver damage that may result following peripheral stem cell transplantation.
- Trial name
- NCT00003966
- Testing
- defibrotide
- Where
- 9 sites in United States
- Volunteers
- 151 people
- Sponsor
- Dana-Farber Cancer Institute
Static Stretching
Determining the Minimal Effective Dose of Static Stretching for Increasing Range of Motion in Adults
The study is planned to be conducted in 2025. The methods used in the study are non-invasive methods. The study groups will perform 1 to 3 static stretching sessions per week. The number of series per session will be from 1 to 3.
- Trial name
- NCT06960590
- Testing
- Training - static streching
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Asthma
Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
To determine whether addition of ipratropium bromide to salbutamol nebulisations produces significantly greater bronchodilation in young children presenting to an emergency department with an acute attack of asthma
- Trial name
- NCT02235428
- Testing
- Ipratropium bromide, Salbutamol
- Volunteers
- 3 people
- Sponsor
- Boehringer Ingelheim
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited
Perianal Surgery
Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Saddle Block
The optimal anesthetic technique would provide excellent operating conditions, rapid recovery, early discharge, no postoperative side effects, and high patient's satisfaction.
- Trial name
- NCT02299167
- Testing
- Dixon's up-and-down method
- Volunteers
- 35 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Bronchoscopy, Anesthesia
An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Flexible Bronchoscopy
Very often patients receive medication before a diagnostic, therapeutic, or surgical procedure to help them relax, keep them calm, and to relieve them from pain. This is called procedural sedation.
- Trial name
- NCT00306722
- Testing
- AQUAVAN® (fospropofol disodium) Injection
- Where
- 25 sites in United States
- Volunteers
- 250 people
- Sponsor
- Eisai Inc.
Schizophrenia, Schizoaffective Disorder
Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia.
Since side effects of antipsychotics, dopamine D2 receptor blockers, frequently occur in older patients with schizophrenia and the risk is dose dependent, clinical guidelines universally advocate the use of lower doses.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Delusional Disorder
- Trial name
- NCT00716755
- Testing
- Risperidone/Olanzapine and PET scans
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Centre for Addiction and Mental Health
Chemotherapy-induced Nausea and Vomiting
Phase II Proof-of-concept Study of APD421
Evaluation of efficacy of APD421 in preventing nausea and vomiting caused by cisplatin
- Trial name
- NCT01303978
- Testing
- APD421
- Where
- 4 sites in Denmark, United Kingdom
- Volunteers
- 51 people
- Sponsor
- Acacia Pharma Ltd
Postoperative Pain Management, Video-assisted Thoracoscopic Surgery (VATS)
Minimum Effective Volume of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Video-Assisted Thoracoscopic Surgery
This study determined the median effective volume (EV50) of bupivacaine required for the serratus posterior superior intercostal plane (SPSIP) block in patients undergoing video-assisted thoracoscopic surgery (VATS).
- Trial name
- SPSIP-EV50 (NCT07446959)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Bursa City Hospital
Osteoarthritis, Knee, Knee Injuries
Motor-Sparing Femoral Nerve Block Dose
Femoral nerve blocks are commonly used to provide pain control for total knee replacement, anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02909257
- Testing
- Same Bupivacaine Concentration, Lower Bupivacaine Concentration
- Where
- Chile
- Volunteers
- 31 people
- Sponsor
- University of Chile
Anesthesia, General
Use of Sugammadex Administered at 5 Minutes After Administration of 1.2 mg/kg Esmeron® (19.4.205)(P05942)
The purpose of this study is to determine the optimal dose of sugammadex when this compound is administered during deep neuromuscular block.
- Trial name
- NCT00379613
- Testing
- sugammadex
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
Motion Sickness
The Minimum Effective Dose (ED90) of Liposomal Bupivacaine for Preserving Motor Function
Explore the minimum effective dose of liposomal bupivacaine for preserving motor function
- Trial name
- ED90 (NCT06587386)
- Testing
- First patient Bupivacaine liposome and next patient Bupivacaine liposome
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Breast Neoplasms, Breast Cancer, Metastatic
Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Breast Cancer
The purpose of this study is to determine whether the study drug is effective and safe in the treatment of patients with metastatic breast cancer
- Trial name
- NCT00288249
- Testing
- Sagopilone (BAY86-5302, ZK 219477)
- Where
- 21 sites in Austria, Belgium and 8 more
- Volunteers
- 82 people
- Sponsor
- Bayer
Sickling Disorder Due to Hemoglobin S
131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
The purpose of this study is to find the smallest amount of the 131 I-apamistamab needed for preparing patients with severe sickle cell disease (SCD) for a bone marrow transplant.
- Trial name
- NCT07015684
- Testing
- 131I-apamistmab, Sirolimus, Campath
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Retinitis Pigmentosa 11, Retinal Degeneration
A Repeat-Dose, Open-Label, Two Arm Safety and Efficacy Study of Two Doses of VP-001 Administered Intravitreally in Participants With Confirmed PRPF31 Mutation-Associated Retinal Dystrophy, Including Participants Previously Treated With VP001
This is a Phase 1/2 repeat-dose, open-label, two-arm, parallel group safety and efficacy study of two doses of VP-001 (30 μg and 75 μg) in participants with confirmed PRPF31 mutation-associated retinal dystrophy, including…
- Conditions
- Retinitis Pigmentosa 11, Retinal Degeneration, Retinal Disease, Eye Diseases Hereditary
- Trial name
- DINGO (NCT06852963)
- Testing
- VP-001
- Where
- 6 sites in United States
- Volunteers
- 17 people
- Sponsor
- PYC Therapeutics
Pain Management, Spine Surgery
Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery
Incisional pain is a common complication after surgery and is an important cause of delayed postoperative recovery, increased length of hospital stay, increased risk of wound infection and respiratory/cardiovascular…
- Trial name
- NCT06785350
- Testing
- 0.012%diprospan+0.5%ropivacaine, 0.009%diprospan+0.5%ropivacaine, 0.006%diprospan+0.5ropivacaine
- Where
- China
- Volunteers
- 535 people
- Sponsor
- Beijing Tiantan Hospital
Lymphangioleiomyomatosis
A Study to Determine the Safety and Effectiveness of RAD001 (Everolimus) in Patients With Lymphangioleiomyomatosis
This was an exploratory study to determine whether escalating doses of RAD001 (everolimus) were safe and effective in patients with Lymphangioleiomyomatosis
- Trial name
- NCT01059318
- Testing
- Everolimus
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals