Clinical trials: Minimum Effective Dose
Postoperative Pain
Effect of Preemptive Intramuscular Diclofenac on Minimal Effective-Dose Bupivacaine Saddle Block for Minor Perianal Surgeries
The research will be carried out in order to test the effect of Intramuscular (IM) Diclofenac, administered as preemptive analgesic with minimal effective dose spinal anesthesia in perianal surgeries, on prolonging the time to…
- Trial name
- NCT04849468
- Testing
- Declofenac, saline
- Where
- Saudi Arabia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Static Stretching
Determining the Minimal Effective Dose of Static Stretching for Increasing Range of Motion in Adults
The study is planned to be conducted in 2025. The methods used in the study are non-invasive methods. The study groups will perform 1 to 3 static stretching sessions per week. The number of series per session will be from 1 to 3.
- Trial name
- NCT06960590
- Testing
- Training - static streching
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heathy Women, Pre Menopausal Age
Estimation of Minimum Efficacy Daily Dose of Jarlsberg Cheese
Aim: To estimate an oral administered recommended minimum efficacy daily dose (MED) of Jarlsberg cheese in order to obtain the needed increased level of Osteocalcin defined as the ratio [Carboxylated / Under Carboxylated]…
- Conditions
- Heathy Women, Pre Menopausal Age, Exlution Criteria: Gastrointestinal Disorder, Liver Disease
- Trial name
- NCT04185454
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prof Stig Larsen
Female Infertility, Ovarian Insufficiency
Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol
The aim of this study is to assess the oocyte yield of infertile women with suspected or known poor ovarian reserve (POR) undergoing a GnRH antagonist protocol for IVF with Merional® starting either with a low (150 IU) or a high…
- Trial name
- CANTAPOR (NCT01577472)
- Testing
- High Dose Clomiphencitrat, Low Dose Clomiphencitrat
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Post Procedural Pain Management in Neonates
Comparison of Minimal Effective Dose of Sucrose for Pain Relief in Neonates After Minor Procedure
Type of Study: Randomized Controlled Trial Aim: To compare the effectiveness of two doses of sucrose solution for pain relief in neonates after minor procedures.
- Trial name
- NCT06446323
- Testing
- 0.2 ml dose of sucrose
- Where
- Pakistan
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Acute Pain
Minimum Local Anesthetic Volume of Bupivacaine in Labour Epidurals
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the most commonly used drugs for that purpose. The efficacy of a certain medication injected epidurally depends on the dose that is given.
- Trial name
- NCT00450099
- Testing
- bupivacaine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Suppression of Ovulation
Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol
The aim of the present study was to evaluate the ability of several doses of NOMAC in combination with E2 to inhibit ovulation and to assess changes in the gonadotropin and ovarian hormone profiles, in comparison to a control…
- Trial name
- NCT01361958
- Testing
- NOMAC
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theramex
Knee Pain Intermittent
Effect of Cis-9-cetylmyristoleate in Sub-healthy Subjects Presenting With Knee Joint Pain
Cis-9-cetylmyristoleate (CMO) is a naturally occurring fatty acid complex (FAC). Nutraceuticals containing CMO are used to improve knee pain despite the lack of placebo-controlled studies in humans.
- Trial name
- NCT02800759
- Testing
- JOINTRUS®, 80% dose of JOINTRUS®, 62.4% dose of JOINTRUS®
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Spinal Anesthesia
Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery
Ropivacaine is one of commonly used anesthetics for spinal anesthesia. Usually L2-3 or L3-4 intervertebral space is chosen for spinal anesthesia.
- Trial name
- NCT02565303
- Testing
- Intervertebral space, Ropivacaine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Underdosing of Unspecified General Anesthetics
Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade
Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for…
- Trial name
- NCT02454868
- Testing
- Remifentanil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Primary Gonarthrosis
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying…
- Trial name
- NCT05806021
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Menorrhagia
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
Many women have heavy periods and this can be associated with low blood, tiredness and inability to carry out normal activities. Approximately 10-30% of these women will have an underlying bleeding disorder.
- Trial name
- NCT00904709
- Testing
- tranexamic acid
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- K. Sue Robinson