Clinical trials: Miscarriages
Infertility, Miscarriage, Recurrent
ANXA5 M2 Haplotyping in IVF Patients and Embryos
This study aims to characterize the association between history of pregnancy complications and M2 carrier status in IVF patients and the utility of M2 haplotype preimplantation genetic testing (PGT) in embryos produced by carrier…
- Conditions
- Infertility, Miscarriage, Recurrent, Pregnancy Complications
- Trial name
- NCT04544462
- Testing
- M2 Test
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Missed Abortion
Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage
Aim of study Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester.
- Trial name
- NCT04593108
- Testing
- Letrozole misoprostol
- Where
- Egypt
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Dr.Dalia Mohammed Al Sayed Zaki
Early Miscarriage
Identification of Histories of Pregnancy Termination, Particularly Early Miscarriage, in General Medical Records
Early miscarriage (EM) is defined as the spontaneous expulsion of an intrauterine pregnancy of less than 14 weeks' duration. Early miscarriage is a very common complication, affecting more than 10% of pregnancies.
- Trial name
- NCT07406776
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Medical; Abortion, Fetus
Fertility and Obstetric Outcomes After Medical Management Versus Surgical Treatment for First-trimester Miscarriage First-trimester Miscarriage
Study Objective: To compare the time to new pregnancy and pregnancy outcomes in women who received Misoprostol for uterus evacuation versus those treated surgically with dilatation and curettage.
- Trial name
- NCT03570307
- Testing
- medical VS surgical evacuation of the uterus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Pregnancy
Does Preimplantation Genetic Diagnosis for Sex Selection Affect the Pregnancy and Miscarriage Rates in Women With an Expected Good Ovarian Response Undergoing IVF/ICSI Cycles?
Records of women who had Pre-genetic diagnosis (PGD) over the last 3 years will be reviewed and its outcome will be compared to other records of women who had IVF/ICSI without PGD.
- Trial name
- NCT02149251
- Testing
- Pre-genetic diagnosis
- Where
- Egypt
- Volunteers
- 11,006 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy Complications
Measuring sVAP-1 as a Predictor of Pregnancy Problems
Pre-eclampsia is a common pregnancy disorder defined as high blood pressure and protein in the urine after 20 weeks of pregnancy.
- Trial name
- NCT04891315
- Testing
- Blood test for soluble VAP-1 (sVAP-1).
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Recurrent Miscarriage
Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
Evaluating the effect of intralipid on the natural killer cells
- Trial name
- NCT03132779
- Testing
- Intralipid
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Bahaa Eldin Ahmed
Recurrent Miscarriages
Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner.
- Trial name
- NCT00180804
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Improvement of Embryo Transfer Technique, Improvement of Implantation
Comparative Study of Three Different Embryo Transfer Media in ICSI Cycles
The study design is a prospective randomized uncontrolled clinical trial. It will include 150 cases. The aim of this study is to compare the efficacy of three different media used for embryo transfer regarding "chemical and…
- Trial name
- NCT02792673
- Testing
- embryos will be transferred using a medium of 0.5 mg/mL of Hyaluronan-enriched medium (EmbryoGlue®, Vitrolife, Sweden), embryos will be transferred using a medium of 30% Protein-supplemented Culture Medium (Global total®, Life Global group, Canada), a novel technique in which embryos will be transferred using a medium of autologous Follicular Fluid
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- South Valley University
Pregnancy-induced Hypertension
Basic and Clinical Research of Pregnancy-Induced Hypertension
Collect blood pressure, blood, amniotic fluid, placenta and other samples from normal pregnant women, patients with pregnancy-induced hypertension and those who have experienced miscarriage, and conduct tests on them.
- Trial name
- BCRPIH (NCT07464379)
- Testing
- no Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Retained Products of Conception Post Abortion
Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products
We speculate that the use of combined oral contraceptives may be a possible solution to promote the management of retained pregnancy products versus expectant management.
- Trial name
- NCT03230825
- Testing
- Oral contraceptive, Expectant management
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Miscarriage in First Trimester
Machine Learning Miscarriage Management Clinical Decision Support Tool Study
Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient.
- Trial name
- MLMM (NCT06384144)
- Testing
- Expectant Management of First Trimester Miscarriage, Medical Management of First Trimester Miscarriage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Spontaneous Abortion, Missed Abortion
Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion
Randomizedtrial comparing success and complication rates of operative hysteroscopy versus traditional dilation and curettage (D\&C) in the management of first trimester missed abortion.
- Conditions
- Spontaneous Abortion, Missed Abortion, Intrauterine Adhesion, Retained Products of Conception
- Trial name
- NCT04705324
- Testing
- Operative Hysteroscopy, D&C, Operative Hysteroscopy - safety and feasibility
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Insulin Resistance
Insulin Resistance in Recurrent Miscarriage
The objective of this study is to study the association between insulin resistance and recurrent spontaneous miscarriage (RSM).
- Trial name
- IRRM (NCT02705248)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Threatened Miscarriage in First Trimester
Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage
evaluation of serum CA125 level and yolk sac morphology in women with threatened miscarriage is very important to predict pregnancy outcome
- Trial name
- NCT03320213
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility, Recurrent Miscarriage
Effect of Influenza Vaccination on Donor Egg Recipient Outcomes
In this study the investigators propose a randomized controlled trial to evaluate the effect of influenza vaccination on clinical pregnancy rates among women undergoing in vitro fertilization as donor egg recipients.
- Trial name
- DE-FluVac (NCT02946177)
- Testing
- Influenza Vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction