Clinical trials: Mitochondrial
There Are no Conditions Under Study. Healthy Volunteers
Eccentric Cycling Exercise With Assistive Devices on Mitochondrial Metabolism in T Lymphocyte
Eccentric cycling exercise can be a promising modality fwith lower respiratory demands and higher power output. Assistive devices like neuromuscular electrical stimulation (NMES) and compressive garment (CG) accelerates muscle…
- Trial name
- NCT06905964
- Testing
- Eccentric cycling exercise (ECC), Eccentric cycling exercise with assistive devices (ECA)
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mitochondrial Diseases, Bone Remodeling Disorder
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling
Cell and mice studies suggest mitochondrial dysfunction may cause altered bone structure. Hypothesis: Decreased mitochondrial energy production affects bone cell development and activity negatively.
- Trial name
- NCT05483738
- Testing
- Clinical assessment, blood samples, bone marrow and bone biopsy
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Exercise Training
Hyperbaric VO2max Study
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude.
- Trial name
- NCT02356900
- Testing
- Hyperoxic hyperbaric interval exercise training, Normoxic, normobaric, interval exercise training, Oxygen
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Female Infertility Due to Advanced Maternal Age
Mitochondrial Energy Production in ART (Assisted Reproductive Technology )
Oocyte maturation requires a lot of energy, which is provided by the mitochondria via the synthesis of ATP. The majority of patients with advanced maternal age (AMA) have poor egg quality.
- Trial name
- Mitenergy (NCT02727400)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Vitamin D Deficiency
Follicular Fluid, Bioavailable Vitamin D and Embryo Quality Markers
To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.
- Trial name
- NCT03073720
- Where
- United Arab Emirates
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Severe Sepsis, Septic Shock
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients.
- Trial name
- NCT00541827
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Aging
Urolithin A Supplementation to Boost Immune Health
To show that a natural mitophagy activator (Urolithin A) given orally can modulate mitochondrial activity in immune cells in healthy adults and this results in better immune function
- Trial name
- NCT05735886
- Testing
- Softgel containing 250mg of Urolithin A (Mitopure)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Embryo Metabolic Activity
mtDNA and Embryo Metabolism
The present study has the objective to study whether the mitochondrial DNA copy number values that can be generated when human embryos are analyzed for chromosomal content before embryo transfer correlates with the actual number…
- Trial name
- NCT03206697
- Testing
- Mitochondrial DNA content and metabolic parameters
- Where
- Spain
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Sarcopenic Obesity, Frailty
Multicomponent Analysis of phYsical Frailty BiomarkErs: Focus on Mitochondrial Health - MAYBE
The study will be conducted in a group of obese sarcopenic patients (Sarco-Ob) aged > 60 years on moderately hypocaloric diet therapy aimed at comparing the effect of a strength exercise protocol, combined or not with dietary…
- Conditions
- Sarcopenic Obesity, Frailty, Malnutrition; Protein
- Trial name
- MAYBE (NCT05938205)
- Testing
- AA-1, AA-2, Exe-H
- Where
- Italy
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Accumulation of lipid in skeletal and cardiac muscle has been associated with insulin resistance and diabetic cardiomyopathy. In skeletal muscle, lipotoxic damage has been suggested to lead to dysfunction of mitochondria.
- Trial name
- ACP (NCT00943059)
- Testing
- Acipimox, Cellulosum Mycrocryst
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Mitochondrial Dysfunction, COVID-19
In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.
To date, little is understood regarding post-COVID fatigue or cancer fatigue though it is known to affect a large proportion of patients (10-70% depending on the population).
- Conditions
- Mitochondrial Dysfunction, COVID-19, Fatigue
- Trial name
- NCT05753228
- Testing
- MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS), Chalder Fatigue Scale, Health Questionnaire (EQ-5D-5L)
- Where
- Singapore
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Bipolar 1 Disorder, Control Subjects
Socio-cognitive and Biological Responses to Maltreatment
The study will investigate how a history of emotional childhood maltreatment (CM) is associated with different aspects of psychological (social behaviour, empathy) and biological (brain function and structure, inflammation)…
- Trial name
- NCT07101107
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Mitochondrial Diseases, Obesity
Muscle OXPHOS and Nutrient Homeostasis
Investigators are recruiting adults (men and women, ages 18 to 65 years, inclusive) with a confirmed genetic diagnosis of mitochondrial disease.
- Trial name
- NCT02920671
- Testing
- Tracer-enhanced oral glucose tolerance test (OGTT*), Muscle MRI, Dual energy x-ray absorptiometry (DXA)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hereditary Transthyretin Amyloidosis
Exploring Biomarkers in Hereditary Transthyretin Amyloidosis
Hereditary transthyretin amyloidosis (ATTRv, v for variant) is a severe and heterogeneous systemic condition due to mutations in the transthyretin (TTR) gene.
- Trial name
- ELBA (NCT05929209)
- Testing
- Assessment of disease biomarkers
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mitochondrial Disease
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity
Background: Mitochondrial disease is a rare disorder. It can cause poor growth, developmental delays, muscle weakness, and other symptoms. The disease is usually inherited. It can be present at birth or develop later in life.
- Trial name
- NCT04419870
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Muscle Mass and Strength, Menopause
Significance of Estrogen Status for Muscle Function, Physical Fitness, and Physiological Health Parameters - a Comparison of Age-matched Groups of Women Before and After Menopause.
As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function.
- Trial name
- HER-MUSCLEX (NCT07649356)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mette Hansen
Periodontal Disease, Periodontal Bone Loss
Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.
The present study is an effort to investigate the hypothesis that Platelet Rich Fibrin/Biphasic Calcium Phosphate may play a role in inhibiting osteoclasts differentiation and in bone loss.
- Conditions
- Periodontal Disease, Periodontal Bone Loss, Osteoclastic Bone Loss
- Trial name
- NCT03227367
- Testing
- other : PRF
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Type 1 Diabetes
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). Non-esterified fatty acid elevation is a significant contributor to IR in T1D and may be a target of…
- Trial name
- AcT1 (NCT01816165)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cancer, Cachexia
Mitochondrial Respiratory Function in Mammalian Skeletal Muscle
The purpose of this study is to determine whether skeletal muscle mitochondrial function is altered in patients with head and neck cancer compared to healthy controls.
- Trial name
- NCT02650570
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypoxia
Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers
In this clinical study, the investigators will compare vital parameters measurements obtained using continuous data from reference monitors and continuous wireless MultiSense® monitoring patch in 30 healthy volunteers under…
- Trial name
- HYPO (NCT05044585)
- Testing
- Remote Automated Monitoring System
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- IHU Strasbourg