Clinical trials: Mitral Insufficiency
Healthy Infants
Measurement of in Vivo Mitochondrial Capacity in Infants
The overarching aim of this project is to determine the test re-test reliability of 31P-magnetic resonance spectroscopy measurements in infants.
- Trial name
- NCT03976596
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
31P Magnetic Resonance Spectroscopy Fructose Study
The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
- Trial name
- 31PMRS_FRU (NCT02217605)
- Testing
- Fructose
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stephen Bawden
Visual Snow Syndrome, Migraine
Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: Does VSS arise from spontaneous activity in brain pathways?…
- Conditions
- Visual Snow Syndrome, Migraine, Healthy
- Trial name
- VPVSS (NCT06961864)
- Testing
- Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Squamous cell carcinoma (SCC) could be a very aggressive cancer and has a bad prognosis if not detected early and thus is associated with high mortality.
- Conditions
- Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma, Proton Magnetic Resonance Spectroscopy, Transcriptomics
- Trial name
- ClimaBio (NCT06450080)
- Testing
- MRI and MRS acquisitions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Assay Muscle, Liver Glutathione in Healthy Human
Non-invasive Quantification of Muscle and Liver Glutathione GSH-MRS
Glutathione (glutamyl-cysteinyl-glycine) is the main intracellular compound. It participates also in the detoxification of electrophiles molecules of which paracetamol.
- Trial name
- NCT02662816
- Testing
- Proton magnetic resonance spectroscopy (1H MRS), a protein rich breakfast at home, a protein rich lunch at the Clinical Investigation Center
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Alzheimer Disease (AD)
Brain NAD in Alzheimer's Disease
The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease.
- Trial name
- ALZNAD (NCT07127510)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Cocaine Dependence, Healthy
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density.
- Trial name
- NCT02124941
- Testing
- N-acetyl cysteine, [18F]FDG PET scan, 1H MRS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA)
Neuroinflammation in FTLD
The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1.
- Conditions
- Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT06870838
- Testing
- 7T MRI scan, CSF, Blood withdrawal
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Major Depressive Disorder, Major Depressive Episode
MRS and Medication Response: A Pilot Study
We hope to demonstrate that magnetic resonance spectroscopy can detect brain concentration levels of paroxetine (Paxil) or citalopram (Celexa) or escitalopram (Lexapro) in depressed patients.
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent, Major Depression Mild
- Trial name
- NCT03254342
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia
Modulation of Repetitive Transcranial Magnetic Stimulation on Hippocampal Neurogenesis and Functional Network in Patients With Schizophrenia
Based on the hypothesis that high-frequency repetitive transcranial magnetic stimulation(rTMS) on the right dorsolateral prefrontal cortex(DLPFC) and left parietal cortex(LPC) could normalise cognitive abnormalities by promoting…
- Trial name
- NCT03608462
- Testing
- repetitive transcranial magnetic stimulation(DLPFC), repetitive transcranial magnetic stimulation(LPC)
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Hepatitis C, Hepatitis B
Application of 18F-FDOPA PET and Magnetic Resonance Spectroscopy (MRS) With HCV and PD
The objective of this study is to investigate the evidence of dopaminergic toxicity causing by HCV infection using 18F-FDOPA PET and MRS as imaging biomarkers.
- Conditions
- Hepatitis C, Hepatitis B, Parkinson Disease
- Trial name
- NCT03973502
- Testing
- 18F-DOPA PET
- Where
- Taiwan
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mucopolysaccharidosis Type I
MRS to Determine Neuroinflammation and Oxidative Stress in MPS I
Neuroinflammation and oxidative stress have been shown to be present in persons with mucopolysaccharidosis type I (MPS I), but their effect on disease severity and disease progression is unknown.
- Trial name
- NCT03576729
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rheumatic Heart Disease, Acute Rheumatic Fever
Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren
Rheumatic heart disease remains a major challenge in low and middle income countries. Early detection of clinically silent valvular lesions by screening echocardiography allows timely implementation of secondary antibiotic…
- Trial name
- NCT02353663
- Testing
- Echocardiography
- Where
- 2 sites in Peru, Switzerland
- Volunteers
- 1,023 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Nicotine
Nicotine and Brain Imaging Research Study
The aim of this study is to assess the impact of smoking on cortical GABA levels in males and females. Using magnetic resonance spectroscopy (MRS), we will examine the impact of sex and menstrual cycle phase on brain…
- Trial name
- NCT01227343
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alveolar Bone Resorption, Alveolar Ridge Enlargement
Modified Ridge Splitting Technique Using Autogenous Bone Blocks (MRS)
In this clinical study ridge splitting procedures are preformed using autogenous bone blocks. After a 3-month healing, at the time of dental implant placement bone core biopsy samples are harvested.
- Trial name
- MRS (NCT05005858)
- Testing
- Alveolar ridge splitting, Creating osteotomies with piezoelectric device
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Alzheimer's Disease
Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
Recent data show that marked cell damage precedes the clinical manifestation of Alzheimer's disease (AD). Hence, targeting populations at risk with pharmacological interventions is a possible strategy to lessen the burden of the…
- Trial name
- NCT00933608
- Testing
- memantine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
First Episode Psychosis (FEP)
Dopamine and Insulin in Psychosis
Patients with schizophrenia have a high risk of developing metabolic disorders and current evidence points to an overlap in mechanisms underlying psychiatric symptoms and metabolic disturbances.
- Trial name
- DIPS (NCT07252752)
- Testing
- Intranasal Insulin, Low dose insulin infusion, [11C] (+)-4-propyl-(+)-4-propyl-9-hydroxynaphthoxazine (PHNO)
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Spinal Cord Diseases
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
Decompressive surgery to relieve symptoms of spinal cord compression due to dysfunction, such as arthritis, has proved variable in success.
- Trial name
- NCT00447343
- Testing
- Decompressive cervical spine surgery, fMRI and MRS scan
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypertension
Physical Fitness, Cardiovascular and Brain Health
The goal of this study is to determine if aerobic exercise or progressive muscle relaxation is associated with changes in cardiovascular health, brain function, and cognition.
- Trial name
- NCT01341145
- Testing
- Aerobic Exercise, Relaxation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin