Clinical trials: Mitral Valve Regurgitation
Heart Defects, Congenital, Heart Septal Defects, Ventricular
Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation
This study will evaluate the efficacy and safety of angiotensin converting enzyme inhibition (ACE-I) therapy for the treatment of mitral regurgitation (MR).
- Conditions
- Heart Defects, Congenital, Heart Septal Defects, Ventricular, Heart Failure, Congestive
- Trial name
- AceiMR (NCT00113698)
- Testing
- Enalapril
- Where
- 7 sites in United States, Canada
- Volunteers
- 5 people
- Sponsor
- University of Utah
Mitral Valve Insufficiency, Aortic Stenosis Senile
Clinical and Geriatric Assessment in Elderly Patients Before and After TAVI or MitraClip Positioning
Since October of 2014, the Policlinico Umberto I Hospital has an "Heart Team", a group of selected specialists with the task of assessing and identifying eligible patients for valvular aortic transcatheter implantation (TAVI) or…
- Trial name
- NCT03145376
- Testing
- geriatric assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Ischemic Mitral Regurgitation
Stress Echo for Ischemic Mitral Valve Surgery
Comparison patients with CABG alone vs. CABG+mitral surgery with non-massive ischaemic mitral regurgitation (IMR) depending on stress echo data.
- Trial name
- SURVIVE (NCT04023058)
- Testing
- Mitral surgery
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Saint Petersburg State University, Russia
Mitral Regurgitation
Structural Mitral Valve Project
This is a prospective Quality Improvement (QI) study using the Model for Improvement framework. The objective of this study is to implement a structured, comprehensive, innovative, and sustainable approach to the management of…
- Trial name
- NCT05678868
- Testing
- MitraClip procedure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Queen's University
Mitral Insufficiency
Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms.
- Trial name
- NCT06738615
- Testing
- Pressure volume loop evaluation, cardiovascular magnetic resonance imaging, Cardiopulmonary exercise testing (CPET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Atlantic Health System
Mitral Regurgitation, Heart Failure
Remote Monitoring of Patients With Functional Mitral Regurgitation Undergoing Mitraclip Transcatheter Repair
HERMES is a pilot study which aims at exploring the impact of remote monitoring in patients with severe functional mitral regurgitation undergoing transcatheter mitral valve edge-to-edge repair with the Mitraclip system.
- Trial name
- HERMES (NCT02698150)
- Testing
- HERMES tablet
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Azienda Ospedaliero, Ferrarotto Alessi
Tricuspid Valve Regurgitation, Non-rheumatic, Mitral Valve Regurgitation
Atrioventricular Valve Regurgitation Vena Contracta; Echo Versus MRI
The purpose of this pilot study is to evaluate mitral (left atrioventricular valve) and tricuspid (right atrioventricular valve (AVV)) regurgitation using cardiac magnetic resonance imaging (CMR) as the non-invasive "gold…
- Trial name
- NCT01504880
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Mitral Valve Insufficiency
Determinants of the Progression and Outcome of Mitral Regurgitation
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing with the aging of the population.
- Trial name
- PROGRAM (NCT01835054)
- Testing
- Blood biomarkers, DNA collection, Echocardiography
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 440 people
- Sponsor
- Laval University
Mitral Regurgitation
Enhanced External Counter Pulsation on Afterload Mismatch Rate in Post-TEER (PAMPER)
The goal of this multicenter, randomized, double-blind controlled study is to learn about the individuals after transcatheter edge-to-edge mitral valve repair (TEER).
- Trial name
- NCT06227286
- Testing
- EECP
- Where
- 6 sites in China
- Volunteers
- 176 people
- Sponsor
- Sun Yat-sen University
Barlow Disease (BD), Mitral Insufficiency
Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease
Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring.
- Trial name
- NCT04418960
- Testing
- Magnetic resonance imaging (MRI)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Hospital, Basel, Switzerland
Nonobstructive Hypertrophic Cardiomyopathy
Transapical Beating-Heart Septal Myectomy in Patients With Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of nonobstructive hypertrophic cardiomyopathy.
- Trial name
- NCT05952154
- Testing
- Transapical beating-heart septal myectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiang Wei
Functional Mitral Regurgitation, Heart Failure
Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF
At present, the optimal treatment strategy for heart failure patients and moderate-to-severe (3+) or severe (4+) mitral regurgitation with a class IIa recommendation for CRT is uncertain.Whether these patents should also be…
- Trial name
- EVOLVE-HF (NCT02985268)
- Testing
- MitraClip, Optimal Medical Therapy, CRT-D
- Sponsor
- Montreal Heart Institute
Mitral Valve Replacement, Mitral Insufficiency
Outcomes of Complete Versus Partial Preservation of the Sub-valvular Apparatus in Cases of Mitral Valve Replacement
The purpose of this study is to evaluate the outcomes of complete (preservation of both anterior and posterior leaflets) versus partial (preservation of posterior leaflet only) preservation of subvalvular apparatus in cases of…
- Trial name
- NCT06811662
- Testing
- mitral valve replacement
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Aortic Stenosis, Aortic Regurgitation
Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease
This prospective, multicenter, observational cohort study aims to establish a post-market registry framework to evaluate the real-world clinical applicability, long-term safety, and effectiveness of innovative heart valve devices…
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Mitral Regurgitation, Tricuspid Regurgitation
- Trial name
- NCT07605624
- Testing
- Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty
- Where
- China
- Volunteers
- 5,500 people
- Sponsor
- Beijing Anzhen Hospital
Hepatic Encephalopathy
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.
- Trial name
- endtxninHE (NCT01446523)
- Testing
- Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Govind Ballabh Pant Hospital
Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation
ECG and CXR for Predicting Cardiovascular Diseases
This retrospective multicenter cohort study aims to develop and validate an artificial intelligence model integrating electrocardiography (ECG) and chest radiography (CXR) to predict future progression of regurgitant valvular…
- Conditions
- Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation, Regurgitation, Aortic Valve, Regurgitation, Mitral
- Trial name
- NCT07573852
- Where
- China
- Volunteers
- 116,380 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Hypertrophic Obstructive Cardiomyopathy
Transapical Beating-heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy
The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy.
- Trial name
- NCT05332691
- Testing
- Transapical beating-heart septal myectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiang Wei
AF Ablation Patients With Moderate+ FMR and Persistent AF
Catheter Ablation for Functional Mitral Regurgitation in Persistent Atrial Fibrillation: Development and Validation of a Predictive Model-A Multicenter Prospective Cohort Study
Mitral Regurgitation (MR) is the most prevalent type of valvular heart disease in clinical practice, with an average prevalence of approximately 1% in populations with moderate-to-severe or worse MR, which increases significantly…
- Trial name
- NCT07096219
- Testing
- Catheter Ablation, ultrasonic cardiography (UCG)
- Where
- 2 sites in China
- Volunteers
- 556 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke
Reduction of Recurrence of Stroke by Nurse-led Education in Bangladesh
Stroke is a major public issue that can be occurred a patient with severe and unbearable disability for a long time. Recurrence of stroke is increasing due to a lack of knowledge and compliance with treatment regarding the…
- Trial name
- NCT05520034
- Testing
- Health Education
- Where
- Bangladesh
- Volunteers
- 432 people
- Sponsor
- Hiroshima University
Major Depressive Disorder
Treatment Resistant Geriatric Depression in Primary Care
This study involves collaboration between McLean Hospital, Geriatric Medicine at the Cambridge Health Alliance (CHA) and other sites within the Partners and Harvard Medical School network.
- Trial name
- NCT01392287
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital