Clinical trials: Mitral Valve Repair Surgery
Barlow's Disease, Prolapse; Mitral
Minimally Invasive or Conventional Edge-To-Edge Repair for Severe Mitral Regurgitation Due to Bileaflet Prolapse in Barlow's Disease: Does the Surgical Approach Have an Impact on the Long-term Results?
The study evaluates the long-term results of patients affected by bileaflet prolapse in Barlow's Disease, treated with edge-to-edge technique between 1997 and 2011.
- Trial name
- NCT04002648
- Testing
- Right minithoracotomy, Sternotomy
- Volunteers
- 208 people
- Sponsor
- Ospedale San Raffaele
Atrial Functional, Mitral Regurgitation (MR)
PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk
Atrial functional mitral regurgitation (AFMR) develops when enlargement and remodeling of the left atrium and mitral annulus prevent the mitral valve leaflets from closing completely, allowing blood to leak backward through the…
- Trial name
- PRECISE-AFMR I (NCT07741253)
- Testing
- Transcatheter Edge-to-Edge Repair
- Where
- China
- Volunteers
- 182 people
- Sponsor
- China National Center for Cardiovascular Diseases
Patients Waiting for Coronary Artery Bypass Graft Surgery, Patients Waiting for Aortic Valve Repair or Replacement
Pre-operative Rehabilitation for Reduction of Hospitalization After Coronary Bypass and Valvular Surgery.
The PREHAB study is a clinical trial where frail patients waiting for heart surgery are randomly chosen to either receive the current standard of care or to participate in an 8-week exercise/education program at a community-based…
- Conditions
- Patients Waiting for Coronary Artery Bypass Graft Surgery, Patients Waiting for Aortic Valve Repair or Replacement, Patients Waiting for Mitral Valve Repair or Replacement, Patients Waiting for Combined Procedures. (CAGB and Valve)
- Trial name
- PREHAB (NCT02219815)
- Testing
- Prehab Intervention
- Where
- 5 sites in Canada
- Volunteers
- 89 people
- Sponsor
- St. Boniface Hospital
Mitral Regurgitation
Valveclip® Transcatheter Mitral Valve Repair Study
The purpose of this clinical trial is to evaluate the effectiveness and safety of the transcatheter mitral valve repair system in the treatment of patients with moderate or above degenerative mitral regurgitation.
- Trial name
- NCT05021614
- Testing
- Valveclip® Transcatheter mitral valve repair
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai NewMed Medical Co., Ltd.
Coronary Artery Disease, Aortic Valve Stenosis
Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial)
The PACO trial is a randomized clinical trial conducted in Heart Centers of Kuopio and Turku university hospitals. The coronary artery disease, aortic valve stenosis and mitral valve insufficiency patients preparing for elective…
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Valve Insufficiency
- Trial name
- PACO (NCT03470246)
- Testing
- PACO intervention for CABG patients, PACO intervention for AVR patients, PACO intervention for MVR patients
- Where
- Finland
- Volunteers
- 540 people
- Sponsor
- Kuopio University Hospital
Minimal Invasive Cardiac Surgery, Minimal Invasive Cardiac Surgery Mitral Valve Surgery
Serratus Plane Block After Minimally Invasive Mitral Valve Repair
Patients undergoing minimally invasive mitral valve reconstruction via small thoracotomy are randomized into two groups. The intervention group receives serratus anterior plane block after minimally invasive mitral-valve…
- Conditions
- Minimal Invasive Cardiac Surgery, Minimal Invasive Cardiac Surgery Mitral Valve Surgery, Serratus Anterior Plane Block
- Trial name
- NCT05648266
- Testing
- Continous SAPB (Ropivacain), institutional standard of care pain medication protocol
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mitral Regurgitation, Mitral Valve Insufficiency
Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair
The objective of this study is to analyze the safety and efficacy of a novel device for minimally invasive mitral valve repair. Data of the early and intermediate postoperative period will be collected within routine clinical…
- Trial name
- NCT05034471
- Testing
- Mi-Chord™ Device Technologies
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Mitral Regurgitation, Mitral Insufficiency
Study on Safety and Performance of Medtentia Mitral Valve Repair System in Surgical Repair of Mitral Regurgitation
The purpose of the trial is to demonstrate the safety and performance of the Medtentia Annuloplasty Ring (MAR) during mitral valve repair surgery.
- Trial name
- NCT01678144
- Testing
- Mitral valve repair using the Medtentia Annuloplasty Ring (MAR)
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- Medtentia International Ltd Oy
Mitral Regurgitation, Computed Tomography
Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair
This retrospective cohort study investigates how CT-derived tissue quality parameters, serving as markers of metabolic status, predict post-operative atrial fibrillation risk in patients undergoing minimally invasive mitral valve…
- Conditions
- Mitral Regurgitation, Computed Tomography, Atrial Fibrillation
- Trial name
- NCT06707506
- Volunteers
- 114 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Cardiac Surgery, Tricuspid Valve Regurgitation
Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation
The mitral valve is the inflow valve into the main pumping chamber of the heart. It can become leaky or narrow, and cause blood to back up into the blood vessels of the lungs.
- Trial name
- NCT01246947
- Testing
- Tricuspid valve repair, Mitral surgery alone
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Mitral Regurgitation (MR)
Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair
This study aims to test the safety and effectiveness of Force Feedback instruments used during robotic-assisted mitral valve repair with the da Vinci Surgical System, Model IS5000 (dV5).
- Trial name
- NCT07655505
- Testing
- Mitral Valve Repair including the use of Force Feedback instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Intuitive Surgical
Mitral Regurgitation (MR), Pediatric Cardiac Surgery
A Prospective Multicenter Cohort Study on Surgical Treatment Strategies for Pediatric Mitral Regurgitation
This prospective, multicenter cohort study aims to evaluate the outcomes of surgical repair for pediatric mitral regurgitation (MR) in China.
- Trial name
- NCT07284212
- Testing
- conventional mitral valve repair, standardized mitral valve repair
- Where
- China
- Volunteers
- 427 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart; Decompensation, Right Ventricle, Echocardiography
The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal…
- Conditions
- Heart; Decompensation, Right Ventricle, Echocardiography, Hypercapnia
- Trial name
- NCT02757573
- Testing
- Hypercarbia
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Tampere University Hospital
Analgesia, Robotic Surgery
Interest of Serratus Plane Block in Postoperative Analgesia for Robot-assisted Surgery
The aim of the study is to compare the analgesia provided by the serratus plane block with local infiltration of the orifices of the trocars after thoracic robot-assisted surgery.
- Trial name
- NCT03110120
- Testing
- 0.5% levobupivacaine injectable solution with 10 ml of physiological saline, 0.5% levobupivacaine injectable solution with physiological saline
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Mitral Valve Disease
Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery
The objective of this study is to collect in a prospective registry all cases of French patients undergoing an assessment for percutaneous treatment of mitral valve disease on a native valve or due to deterioration after surgical…
- Trial name
- MITRAGISTER (NCT02925819)
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- French Cardiology Society
Mitral Regurgitation
The Effect of Percutaneous Superior Venae Cava Cannulation Clamping on Cerebral Near Infrared Spectroscopy in MICS
The use of minimally invasive cardiac surgery has progressed over the last 5-10 years to allow access to the heart through a small incision in the right chest.
- Trial name
- NIRSinMICS (NCT01166841)
- Testing
- PSVC line clamped
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mitral Valve Repair Surgery
Video-Based AI-Generated Peri-operative Instructions for Mitral Valve Surgery
1. The purpose of this study is to evaluate the impact of a novel, AI-generated, interactive peri-operative video education program on total unplanned healthcare utilization 2.
- Trial name
- VIP-IMPACT (NCT07036926)
- Testing
- Artificial Intelligence Video Education Arm
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Joanna Chikwe
Tricuspid Regurgitation, Mitral Regurgitation
Concomitant Tricuspid Repair in Patients With Left Heart Surgery
Tricuspid regurgitation is common in patients with severe left heart diseases, such as degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform concomitant…
- Conditions
- Tricuspid Regurgitation, Mitral Regurgitation, Cardiopulmonary Bypass
- Trial name
- NCT05595187
- Testing
- Tricuspid repair
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Mitral Valve Insufficiency, Coronary Artery Disease
REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality.
- Trial name
- REVIVE (NCT04822675)
- Testing
- Percutaneous mitral valve repair, Surgical mitral valve repair/replacement
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Mitral Valve Insufficiency, Coronary Artery Disease
Long Term Follow Up for CTSN Mitral Valve Repair Studies
This study is a continuation of two previous studies --- the Severe Ischemic Mitral Regurgitation (SMR) Trial (NCT00807040) and the Moderate Ischemic Mitral regurgitation (MMR) Trial (NCT00806988) --- to learn more about…
- Trial name
- NCT03066050
- Testing
- MV Repair, MV Replacement, CABG
- Where
- 24 sites in United States, Canada
- Volunteers
- 368 people
- Sponsor
- Icahn School of Medicine at Mount Sinai