Clinical trials: Modification
Diabetic Foot Ulcer, Venous Leg Ulcer
A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to determine how well multiple CAMPs (Cellular, Acellular and Matrix-Like Products) and Standard of Care work when compared to Standard of Care alone in achieving complete closure of hard-to-heal…
- Trial name
- NCT06453187
- Testing
- Urinary Bladder Matrix (UBM) sheet device for Venous Leg Ulcers, Urinary Bladder Matrix (UBM) sheet device for Diabetic Foot Ulcers, AmnioExcel Plus for Venous Leg Ulcers
- Where
- 13 sites in United States
- Volunteers
- 350 people
- Sponsor
- Integra LifeSciences Corporation
Obesity, Overweight
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)
The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction in participants who previously completed treatment with injectable tirzepatide (Zepbound) or injectable…
- Trial name
- NCT06584916
- Testing
- Orforglipron
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 376 people
- Sponsor
- Eli Lilly and Company
ST-elevation MI, Hypothermia
Evaluation of Ultrafast Hypothermia Before Reperfusion in STEMI Patients
This study will look at the safety of treating patients with heart attack with mild hypothermia induced using a system of automated peritoneal lavage.
- Trial name
- VELOCITY (NCT01655433)
- Testing
- Velomedix APLS device, No Hypothermia Treatment
- Where
- 7 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Velomedix, Inc.
Gastroesophageal Reflux
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
The purpose of this study is to determine whether Dexlansoprazole once daily (QD) is effective in treating patients with night heartburn.
- Trial name
- NCT00627016
- Testing
- Dexlansoprazole
- Where
- 43 sites in United States
- Volunteers
- 305 people
- Sponsor
- Takeda
Ulcerative Colitis
An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon.
- Trial name
- NCT05791526
- Where
- 114 sites in Japan
- Volunteers
- 308 people
- Sponsor
- AbbVie
Women's Health, Annual Visit
Precision Nudging Drives Wellness Visit Attendance at Scale
The purpose of the present randomized controlled trial is to explore the effectiveness of a 12-month well woman digital health intervention leveraging Precision Nudging - the application of behavioral science and reinforcement…
- Conditions
- Women's Health, Annual Visit, Well Visit, Health Behavior
- Trial name
- NCT05509049
- Testing
- Precision nudging, Standard of care
- Where
- United States
- Volunteers
- 30,068 people, healthy volunteers welcome
- Sponsor
- Lirio
Multiple Sclerosis, Relapsing-Remitting
Healthy Volunteer Study Using 3 Different Formulations of Firategrast
This study will investigate how 3 types of drug formulations are absorbed by the body. This study is termed 'open-label', which means volunteers will be aware of which treatment they are receiving.
- Trial name
- NCT01416363
- Testing
- Firategrast immediate release tablet, Firategrast modified release tablet, Firategrast gastro-retentive solution
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non-Proliferative Diabetic Retinopathy
To Evaluate the Efficacy and Safety of Combination Therapy With B55R1 and B55R2 Compared to B55R1 Monotherapy in Patients With NPDR
This study is planned to evaluate the efficacy and safety of combination therapy with B55R1 and B55R2 compared to B55R1 monotherapy in patients with non-proliferative diabetic retinopathy (NPDR).
- Trial name
- NCT07230184
- Testing
- B55R1 and B55R2
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- AJU Pharm Co., Ltd.
Patients Undergoing Contrast Enhanced Multidetector Computed Tomography of the Chest, Abdomen, Liver or Aorta for Any Diagnostic Cause
Multidetector Computed Tomography (MDCT) Tailored Protocol
Collection of data from different sites regardless of whether they use standard or tailored protocols for the application of high concentration iodinated contrast agents to assess if the individually patient-adapted protocols…
- Trial name
- NCT01737333
- Where
- 2 sites in United States, Italy
- Volunteers
- 1,493 people
- Sponsor
- Bracco Diagnostics, Inc
Ulcerative Colitis
Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will assess how effective upadacitinib is in treating UC.
- Trial name
- EUROPE (NCT05496348)
- Where
- 94 sites in Austria, Germany and 1 more
- Volunteers
- 400 people
- Sponsor
- AbbVie
Healthy Male Volunteers
A Study to Evaluate the Drug Levels, Physical and Chemical Changes, and Removal of BMS-986196 in Healthy Male Participants
The purpose of this study is to evaluate the excretion pathway of orally administered [14C]-BMS-986196 and to assess the safety and tolerability of orally administered BMS-986196.
- Trial name
- NCT05981963
- Testing
- [14C]-BMS-986196
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity
Japanese Dose-Response Study of Rimonabant in Obese Patients
The primary objective is to verify the dose-response relationship of rimonabant on body weight change. The secondary objectives are to compare the effect of 3 doses of SR141716 to placebo, on body weight loss and on secondary…
- Trial name
- NCT00459004
- Testing
- rimonabant (SR141716)
- Where
- Japan
- Volunteers
- 527 people
- Sponsor
- Sanofi
Irritable Bowel Syndrome, Relief of Irritable Bowel Syndrome Symptoms
Effects of Cultura Yoghurt in Irritable Bowel Syndrome (IBS) Patients on Intestinal and Immunological Changes
To determine the effect of cultura probiotic yoghurt on number of responders to treatment during 8 weeks of treatment in comparison to placebo.
- Conditions
- Irritable Bowel Syndrome, Relief of Irritable Bowel Syndrome Symptoms, Quality of Life
- Trial name
- NCT01127828
- Testing
- Arla Yoghurt with no probiotic, Probiotic yoghurt (Cultura)
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Good Food Practice, Sweden
Cognitive Change
Testing the Cognitive Facilitation Effect by Dietary Supplementation of MelaGene+ Drink
To assess the efficacy of MelaGene+ on cognitive performance
- Trial name
- NCT05988593
- Testing
- MelaGene+
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Obesity
The Allurion Digital Behaviour Change Intervention
The proposed study is a prospective, non-randomized, pilot study to test the impact of the Allurion Digital Behaviour Change Intervention (DBCI) in participants who have been treated with the Allurion™ Gastric Balloon System.
- Trial name
- NCT05884606
- Testing
- Allurion Digital Behaviour Change Intervention
- Where
- 4 sites in Netherlands, United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Allurion Technologies
Healthy
Acute Response Capsaicin Flare Study
Prior to administering PF-04427429 to patients we wish to increase the understanding of functional effects associated with calcitonin gene related peptide (CGRP) pathways.
- Trial name
- NCT01147432
- Testing
- PF-04427429, Capsaicin challenge, EMLA positive control
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Acute Myeloid Leukemia
Study to Assess Adverse Events and Change in Disease Activity of Oral Venetoclax in Combination With Subcutaneous (SC) or Intravenous (IV) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Standard Induction Therapy in India
Acute myeloid leukemia (AML) is one of the most aggressive blood cancers, with a very low survival rate and few options for participants who are unable to undergo standard induction therapy, the current standard of care.
- Trial name
- NCT07044687
- Testing
- Venetoclax, Azacitidine
- Where
- 14 sites in India
- Volunteers
- 100 people
- Sponsor
- AbbVie
Growth and Development
fMRI Study to Investigate Hemodynamic Changes in Brain Resulting From Supplementation of Bacopa Monnieri Extract and Multiple Micronutrient Supplementation.
The study will aim to compare the effects of a beverage powder fortified with multiple micronutrients and Bacopa monnieri extract (test product) to a non-fortified isocaloric beverage powder (control product) on cognitive…
- Trial name
- NCT02345187
- Testing
- Beverage powder fortified with Bacopa Monnieri Extract and Multiple Micronutrient supplementation, Non-fortified isocaloric beverage powder
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
A Study to Examine the Long Term Effect of Pramlintide on Body Weight and Its Safety and Tolerability in Obese Subjects
This is a long term extension to study 137OB-201 which is designed to examine the effect of pramlintide on body weight and its safety and tolerability in obese subjects.
- Trial name
- NCT00189514
- Testing
- pramlintide acetate
- Where
- 21 sites in United States
- Volunteers
- 210 people
- Sponsor
- AstraZeneca
Smokers, Never Smokers
Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure
This study intends to evaluate the nasal mucociliary clearance (NMC) by determining the value obtained for saccharin transit time (STT) test over the course of 12 hours following a single cigarette use in adult smokers, to…
- Trial name
- NCT03086707
- Testing
- Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
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