Clinical trials: Modification
Hypertension
Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway.
- Trial name
- NCT06303830
- Testing
- Sodium nitrate
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Exploring Adherence and Acceptability of an Intermittent Carbohydrate Restriction Regime in Free-Living Adults: A Feasibility Study
This study investigates a novel dietary approach called Intermittent Carbohydrate Restriction (ICR), which involves reducing carbohydrate intake on selected days of the week while allowing habitual eating on other days.
- Trial name
- NCT07056465
- Testing
- Intermittent Carbohydrate Restriction (ICR) Protocol
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Obesity
Changing Eating Behaviors in Young Children: Should Healthy Foods be Increased or Unhealthy Foods Decreased?
Recommendations for treatment of childhood obesity in a primary care setting have been developed. These recommendations include beginning treatment with young children, focusing treatment on the parent so the parent can assist…
- Trial name
- NCT00200265
- Testing
- diet
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Weight Reduction, Health Knowledge, Attitudes, Practice
Behavioral Economics-Based Online Lifestyle Balance Program
The objective of this project is to design a Behavioral Economics Based Online Lifestyle Balance Program that employs behavioral economics to engage and motivate adherence to an Internet-based program.
- Trial name
- NCT03534336
- Testing
- Incentive for Education, Incentive for Weight Loss
- Where
- Singapore
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Dietary Modification, Cardiovascular Risk Factor
Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)
Our group has recently identified the association between gut-flora-mediated carnitine and phosphatidylcholine metabolism, specifically trimethylamine-N-oxide (TMAO), and cardiovascular risk.
- Trial name
- GRADY (NCT02016430)
- Testing
- MeLT Dietary intervention, TLC Dietary intervention, MeLT dietary intervention with TMAO
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diet Modification, Chronic Urticaria
Dietary Treatment for Chronic Urticaria
Histamine is a biologically active component that can be found in many foods and beverages. Intake of excessive histamine from foods or beverages, can trigger symptoms including urticaria.
- Trial name
- DTCU (NCT02047136)
- Testing
- Treatment group (on low histamine diet), Well-balanced diet
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hong Kong Sanatorium & Hospital
COVID-19, SARS-COV-2 Infection
A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years
The purpose of this study is to learn about the safety, tolerability, and immunogenicity of an updated vaccine against COVID-19.
- Trial name
- NCT07069309
- Testing
- BNT162b2 (2025/2026 recommended SARS-CoV-2 strain)
- Where
- 19 sites in United States
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Aging
CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Trial name
- NCT00099099
- Testing
- Caloric Restriction (CR)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Obesity, Dietary Modification
Drinking Water to Reach or Maintain a Healthier Weight
The purpose of this study is to find out if drinking extra water helps people lose or maintain weight loss and reduce hunger and, if so, what volume of water is most effective and when is it best to drink it.
- Trial name
- NCT02331316
- Testing
- Daily extra water intake
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- ThinkWell
Otitis Media Acute
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children
A pragmatic, mixed-method trial is to show the ability of OtoSight to change management of the pediatric patient presenting with ear pain in a way that improves patient outcomes and reduces costs.
- Trial name
- OTO-MATIC (NCT06285812)
- Testing
- OtoSight Middle Ear Scope
- Where
- 7 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- PhotoniCare, Inc.
Carer Stress Syndrome, Dementia
Effects of a Modified Mindfulness-based Cognitive Therapy for Family Caregivers of People With Dementia
Caring for people with dementia (PWD) poses many challenges which may cause high levels of caregiver stress. This study aims to investigate the effects of a modified Mindfulness-based Cognitive Therapy for stress reduction in the…
- Trial name
- NCT03354819
- Testing
- Modified MBCT, SIRE on dementia
- Where
- Hong Kong
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Postpartum Weight Retention
A Personalized Telehealth Intervention for Health and Weight Loss in Postpartum Women
The purpose of this study is to help women lose the weight they gained during their pregnancy using a SmartPhone app the investigators have developed called E-Moms.
- Trial name
- E-Moms (NCT01751230)
- Testing
- WIC E-Moms
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Fever, Heart Rate, Fetal (FHR)
Acetaminophen for Fetal Tachycardia: a Randomized Pilot Trial
The most common cause of fetal tachycardia is maternal fever. Fetal tachycardia often precedes the maternal fever, and fetal tachycardia confounds the interpretation of electronic fetal monitoring (EFM), increasing the rate of…
- Trial name
- NCT00377832
- Testing
- Acetaminophen 975 mg
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Obesity
Modifying Obesogenic Homes: Impact on Weight Maintenance
The obesity epidemic observed in recent years can be largely attributed to an obesogenic environment that encourages overeating and sedentary lifestyles.
- Trial name
- NCT00200330
- Testing
- Behavioral weight loss treatment, Behavioral and home environment weight loss treatment
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Molar Incisor Hypomineralization
Evaluation of Three Different Minimally Invasive Techniques for Management of Enamel Opacities in Patients With Molar Incisor Hypomineralization "Randomized Controlled Clinical Trial"
The controlled clinical trial will be done to evaluate Resin infiltration, Resin modified glass ionomer varnish and Light cured giomer varnish as minimally invasive techniques for management of enamel opacities of patients with…
- Trial name
- NCT06135272
- Testing
- Resin infiltration, Resin modified glass ionomer varnish, Light cured giomer varnish
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Myeloid Leukemia
Dynamic Changes in the Levels of sCD62L and SPARC in Chronic Myeloid Leukemia Patients During Imatinib Treatment
This study aims to monitor the levels of soluble L-selectin (sCD62L) and secreted protein acidic rich in cysteine (SPARC) in chronic phase chronic myeloid leukemia (CP-CML) patients at baseline and after three and six months of…
- Trial name
- NCT05387330
- Testing
- ELISA kit
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Tanta University
Malnutrition, Dietary Modification
Basic Care Revisited: Early Nutrition Intervention for Outpatients
Early nursing nutrition intervention for outpatients in need of surgery Objective - To investigate the feasibility and effectiveness of screening and an early nursing intervention on malnutrition in outpatients in need for…
- Trial name
- BCR_N (NCT02440165)
- Testing
- Nursing nutrition intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Achilles Tendinopathy
Does Resistance Training Protocol Change Micromorphology in Achilles Tendinopathy?
This work is designed as a prospective cohort study, in which the effects of a protocol of 12-week resistance training loading the Achilles tendon in patients with Achilles tendinopathy (AT) will be monitored.
- Trial name
- NCT06009536
- Testing
- Achilles Tendon Loading Exercise Protocol According to Silbernagel
- Where
- Czechia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Motol
Ovary Disease
The Relationship With Mad Honey Containing Grayanotoxin and Ovary Tissue
For our working group, eighteen healthy Sprague-Dawley female rats were recruited and separated into three groups in an experimental animal laboratory.
- Trial name
- NCT05643599
- Testing
- Mad Honey, Normal Honey, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Low Back Pain
MyBack - A Behavior Change Informed Exercise Program to Prevent Low Back Pain Recurrences
Low Back Pain is a common heath condition with high rates of recurrence and huge associated costs. Research has focused its efforts on analysing the effects of interventions while knowledge about effective secondary prevention…
- Trial name
- MyBack (NCT05841732)
- Testing
- Usual Care, MyBack Program
- Where
- Portugal
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Instituto Politécnico de Setúbal
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