Clinical trials: Modification
Allergic Rhinitis, Allergic Inflammation
Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study
IgE-associated allergy is a hypersensitivity disease affecting more than 25% of the population in industrialised countries. The recognition of allergen by immunoglobulin E (IgE) plays a central role in the cause of allergic…
- Trial name
- NCT03644680
- Testing
- Nasal Provocation with Birch Extract, Nasal Provocation with NaCl 0.9%
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Infant Nutrition
Formula With Modified Content of Protein and Improved Fatty Acids and Their Impact on Infant Growth and Health
In this study, the suitability of an infant formula with a modified content of protein and fatty acid pattern (LC-PUFA) for healthy term infants will be investigated.
- Trial name
- BEMIM (NCT01094080)
- Testing
- standard infant formula, modified infant formula, breast milk
- Where
- 2 sites in Germany, Serbia
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Sleep Deprivation, Hippocampal Atrophy
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects.
- Conditions
- Sleep Deprivation, Hippocampal Atrophy, Cortical Irregularity
- Trial name
- NCT06260280
- Testing
- Cerebral Nuclear Magnetic Resonance
- Where
- Mexico
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Cholecystolithiasis
The Effect of High Frequency Jet Ventilation (HFJV)During Laparoscopic Operations
Investigators conducted a randomised perspective study to determine whether the use of HFJV instead of conventional mechanical ventilation will reduce the adverse cardiovascular effects of pneumoperitoneum during laparoscopic…
- Trial name
- HFJV (NCT01289379)
- Testing
- High Frequency Jet Ventilation, HFJV
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cardiovascular Diseases, Retina; Change
Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease
This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.
- Trial name
- NCT05082402
- Testing
- Swept Source Optical Coherence Tomography Angiography
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Socket Shield
Comparison of Peri-implant Tissues Using Socket Shield Technique Versus Xenograft
The aim of this study is to clinically and radiographically evaluate the dimensional changes of soft and hard peri-implant tissues around single immediate post-extraction implants in the esthetic zone.
- Trial name
- NCT03684356
- Testing
- socket shield technique, xenograft
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Aging, Protein Metabolism
Metabolite Changes Following Consumption Of Different Protein Drinks In Singapore Older Adults
The study aims to investigate the acute effects of different protein sources (i.e., casein, whey, soy) on metabolomic profiles (e.g., amino acids in the blood), along with other outcomes such as cognitive function, mood, and…
- Trial name
- NCT06956131
- Testing
- Casein Protein Isolate Drink, Whey Protein Isolate Drink, Soy Protein Isolate Drink
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Electroencephalogram, Stress
Does Stress Change EEG Measures in Students: A Feasibility Study
Psychological stress is a frequent human affection and has a considerable impact on modern society, and tertiary-level students often report increased stress levels as the semester progresses.
- Trial name
- EEG_stress (NCT06636253)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Scotland College of Chiropractic
Diabetes Insipidus
Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls
This study is to evaluate oxytocin levels in response to MDMA administration as compared to placebo in patients with diabetes insipidus and healthy volunteers.
- Trial name
- OxyMA (NCT04648137)
- Testing
- study intervention: 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Retrospective Chart Review of the 5 & 2 & 2 and 4 & 2 & 1 Plans
The purpose of this study is to retrospectively and systematically review records of overweight and obese Medifast Weight Control Center (MWCC) members who have been assigned to the 5 \& 2 \& 2 Plan or the 4 \& 2 \& 1 Plan for…
- Trial name
- NCT02150837
- Testing
- 5 & 2 & 2 Plan, 4 & 2 & 1 Plan
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Medifast, Inc.
Body Weight Changes
Infant Peer Interaction Study by Examining the Effect of a 6-week Music Enhancement Program
The overall purpose of this study is to better understand food reinforcement in infants. The results of this study should help to further our understanding of how individuals relate to food and how an enriched environment can…
- Trial name
- NCT04289168
- Testing
- Music
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Diarrhea
Dose Escalating Study of a Prototype CS6 Subunit Vaccine With a Modified Heat-labile Enterotoxin From Enterotoxigenic Escherichia Coli (ETEC)
This study will evaluate the safety of a prototype Coli surface antigen 6 (CS6) subunit vaccine (CssBA) alone or in combination with Escherichia coli double mutant heat labile toxin (dmLT) given by intramuscular (IM) injection.
- Trial name
- NCT03404674
- Testing
- CssBA, dmLT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PATH
Lifestyle Risk Reduction, Type2 Diabetes
Lifestyle Changes Reducing Type 2 Diabetes Risk Among Arab Canadian Muslim Women.
Aim: The purpose was to investigate whether modifiable risk factors for type 2 diabetes can be reduced by an intensive healthy lifestyle intervention designed for Arab Muslim women.
- Trial name
- NCT04708574
- Testing
- Lifestyle intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Congenital Disorder, Heart Diseases
Supported Exercise Programme for Adults With Congenital Heart Disease
This study will evaluate if the introduction of a supported exercise programme can improve physical and psychological well-being for adults with congenital heart disease.
- Trial name
- SEACHange (NCT03262168)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Spinal Muscular Atrophy, Neuromuscular Disorders
Study of Feasibility to Reliably Measure Functional Abilities' Changes in Nonambulant Neuromuscular Patients Without Trial Site Visiting
Clinical trials organization in several neuromuscular disorders (NMD) has some specific issues. Nonambulant status and difficulties with transportation are among them.
- Trial name
- NCT02235090
- Testing
- Direct current stimulation of cervical spinal cord
- Where
- Ukraine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charitable Foundation Children with Spinal Muscular Atrophy
Undernutrition
Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children
Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need…
- Trial name
- NCT07451951
- Testing
- Medium-quantity lipid-based nutrient supplement (MQ-LNS), Small-quantity lipid-based nutrient supplement (SQ-LNS)
- Where
- 2 sites in Pakistan
- Volunteers
- 1,568 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Stress Disorders, Post-Traumatic
Gene Expression Correlates of Post-Traumatic Stress Disorder (PTSD) Symptom Change After EFT (Emotional Freedom Techniques)
The purpose of the study is to measure the change in psychological symptoms and gene expression in war veterans after a series of 10 EFT coaching sessions.
- Trial name
- NCT01250431
- Testing
- EFT (Emotional Freedom Techniques)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Diabetes
Acute Whole Body Vibration Change the Glycemic and Lactate Levels
The type II diabetes is characterized by high levels of blood glucose followed by excessive insulin release so that the target cells become less sensitive and develop insulin resistance, maintaining hyperglycemic levels.
- Trial name
- NCT03542929
- Testing
- whole body vibration
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maíra F Pessoa
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