Clinical trials: Modification
Dietary Intakes, Physical Activity
Implementing Modified Practices to Leverage Evidence for Movement, Engagement, and Nutrition Topics in Early Childcare and Education
The goal of this cluster-randomized, controlled trial is to learn if a professional development program for childcare educators, called the Boston Healthy Child Care Initiative, can help improve the nutritional quality of…
- Conditions
- Dietary Intakes, Physical Activity, Child Care, Early Education
- Trial name
- IMPLEMENT (NCT07874295)
- Testing
- Boston Healthy Child Care Initiative
- Where
- United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Chronic Kidney Diseases, Cardiovascular Diseases
Assessment of Protein Modification in Chronic Kidney Disease - Selected Clinical and Biochemical Aspects
The studies included the effect of chronic kidney disease advancement on the accumulation of oxidative stress markers in plasma. In patients with end-stage renal disease, the effect of replacement therapy was also assessed.
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Dialysis; Complications
- Trial name
- NCT04939870
- Testing
- Biochemical parameters evaluation
- Where
- Poland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Tuberculosis
A Phase I Study of the Safety and Immunogenicity of a Recombinant MVA Vaccine Encoding a Secreted Antigen From M. Tuberculosis, Antigen 85A, Delivered Intradermally by a Needle Injection in Healthy Volunteers.
This study is to assesss the safety and immunogenicity of vaccine based on Modified Vaccinia Ankara (MVA) expressing the 85A antigen (from Mycobacterium. tuberculosis).
- Trial name
- NCT00423566
- Testing
- MVA85A (Tuberculosis vaccine)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Implant Site Reaction
the Peri-implant Tissue Changes Around Implants in the Esthetic Zone Using Demineralized Dentin Graft vs Xenograft
Dentin grafts are categorized into mineralized dentin, partially demineralized dentin matrix (PDDM), and demineralized dentin matrix (DDM).
- Trial name
- NCT06164353
- Testing
- Partially demineralized dentin graft covered with a collagen membrane
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Immune System Processes, Inflammatory Activation and Modulation
The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- NCT01643369
- Testing
- Cognitive-Based Compassion Training, Adult Health Education Curriculum, Mindful Attention Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Weight Reduction, Obesity
Effects of Protein-Enriched Meal on Liver, Kidney or Bone: a Randomized Controlled Trial
This study will examine whether a higher protein meal replacement diet (consisting of 1 gram of protein per pound lean body mass) is more effective in causing weight loss compared to a standard meal replacement protein diet…
- Conditions
- Weight Reduction, Obesity, Weight Management
- Trial name
- NCT01030354
- Testing
- Herbalife Meal Replacements
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Exercise
Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation
The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.
- Trial name
- NCT07297823
- Testing
- Cold temperature, Room Temperature
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Pain, Acute, Pain, Chronic
Changes in Affective Pain Processing in Human Volunteers
The experience of pain is more than the conscious perception of nociceptive signals. Emotional and motivational aspects accompany pain, leading to its aversiveness and motivation for avoidance.
- Conditions
- Pain, Acute, Pain, Chronic, Low Back Pain
- Trial name
- NCT04280796
- Testing
- psychophysical tasks, cognitive task
- Where
- Switzerland
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- susanne becker
Alzheimer's Disease
A Study to Evaluate the Use of an Indwelling Catheter to Obtain Cerebrospinal Fluid (CSF) by Low-rate Continuous Sampling (MK-0000-211)
This is a study to evaluate the feasibility and tolerability of low-rate continuous Cerebrospinal Fluid (CSF) sampling and to estimate the number of participants who exhibit severe baseline instability of CSF amyloid beta isoform…
- Trial name
- NCT01325662
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Body Image Disturbance, Overweight and Obesity
Targeting Weight and Shape Concern Among Women with High Body Weight
This study is a randomized controlled trial to evaluate the effect of an adapted version of the Body Project program among adult women of higher body weight who want to lose weight.
- Conditions
- Body Image Disturbance, Overweight and Obesity, Weight Loss
- Trial name
- NCT05845866
- Testing
- Modified Body Project, Facts about obesity, myths about weight loss, Lifestyle intervention for weight loss
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Healthy, Febrile
Comparison of a Novel Non-Invasive, Non-Touch Infrared Thermometer With Routine Thermometry in Routine Clinical Practice
Quantify the reliability and agreement of estimated core body temperature using the InstaTemp MD™ and other widely marketed reference Thermometers
- Trial name
- NCT02805322
- Testing
- ARC InstaTemp MD, Covidien Genius 2 Tympanic Thermometer, Welch Allen SureTemp Plus Sublingual Thermometer
- Where
- Ireland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- ARC Devices
Healthy
A Study to Learn How the Study Medicine PF-07899895 Are Tolerated and Act in the Body of Healthy Adults
The purposes of the study are as follows: To understand how safe and tolerable are different amounts of study medicine (PF-07899895). To measure the amount of PF-07899895 in blood after the medicine is taken by mouth.
- Trial name
- NCT06137729
- Testing
- PF-07899895
- Where
- Belgium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pfizer
Low Grade Metabolic Acidosis
Changes in Acid Base Status During High Salt Intake
The study aimed to examine the effects of an alkalinisation of a NaCl (sodium chloride, salt)-rich diet on acid base status, bone metabolism, protein turnover and other influenced physiological systems.
- Trial name
- SL8 (NCT01655953)
- Testing
- High NaCl + KHCO3, Control: high NaCl
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Alzheimer's Disease
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
The purpose of this study is to find a modified release oral tablet formulation for this drug, which will be safe and well tolerated.
- Trial name
- NCT02710188
- Testing
- HTL0009936 modified release, HTL0009936 immediate release
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Postoperative Pain, Gas Bloat Syndrome
The Effect of Kinesio Taping and Breathing Exercises on Pain Management
A randomised clinical trial in a single centre.The aim of this study is to evaluate the effect of kinesio taping and breathing exercises on pain management applied after benign gynecological abdominal operations.
- Conditions
- Postoperative Pain, Gas Bloat Syndrome, Defecation Disorders
- Trial name
- NCT04412122
- Testing
- Kinesio Taping, Breathing Exercise, Kinesio Taping+Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Saliva Altered, Plaque
Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients
This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both…
- Trial name
- NCT03877705
- Testing
- Listerine ready tabs
- Where
- Egypt
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University
The Serum Native Thiol (NT), Total Thiol (TT)
Effect of Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin Levels on IVF Results in Male Factor Infertility
Thiol-disulfide Homeostasis (TDH) is essential for physiological functions in the human reproductive system, including antioxidant defense, detoxification, signal transduction, enzymatic regulation, apoptosis, and cellular…
- Conditions
- The Serum Native Thiol (NT), Total Thiol (TT), Serum Disulfide/TT Ratio, NT/TT Ratio
- Trial name
- IVF (NCT07033429)
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Duzce University
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Overweight or Obesity
Effect of a Modified 5:2 Intermittent Fasting Diet on Population With Overweight or Obesity in China
This study aimed to investigate the effects of the modified 5:2 IF dietary intervention on the Chinese population with overweight or obesity based on a self-controlled clinical trial.
- Trial name
- NCT06552403
- Testing
- A modified 5:2 intermittent fasting diet
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Tongde Hospital
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