Clinical trials: Modification
Exercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear.
- Trial name
- NCT06715748
- Testing
- Ketone Monoester (KE)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Obesity
Evaluation of the Shape Up Rhode Island Campaign Study 5
Obesity is a major health problem that has reached epidemic levels. Efforts are needed to develop cost-effective public health approaches for weight loss and maintenance.
- Trial name
- NCT00948415
- Testing
- Evaluation of the Shape Up RI Campaign
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Tobacco Use, Smoking
CSD231005 Nicotine Pouch Biomarkers of Exposure
This will be a multi center open label, randomized, controlled, switching parallel-group study designed to assess changes in select biomarkers of exposure (BoE) in generally healthy smokers following a 5 day in-clinic switch to…
- Trial name
- NCT06303115
- Testing
- Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine
- Where
- 5 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Orthognathic Surgery
Prediction Accuracy of Dolphin 3D in Bimax Surgery for Class III
Patients with class III dentofacial deformity who are in need of surgical correction are now able to see the potential changes to their faces before the actual operation.
- Trial name
- NCT04353635
- Testing
- dolphin 3d
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Body Weight, Body Image
WFPB Lifestyle and Muscle Mass Preservation
Body fat (BF) and muscle mass showed opposing association with mortality. Whole-food, plant-based (WFPB) lifestyle programs has been on the rise lately especially due to impressive health benefits.
- Conditions
- Body Weight, Body Image, Body Weight Changes, Muscle Loss
- Trial name
- WFPBmuscle (NCT04849689)
- Testing
- Whole-food, plant-based lifestyle
- Where
- Slovenia
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Drug-induced Surface ECG Changes
Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects
This study seeks to compare 4 known QT prolonging drugs versus placebo to determine their effects on electrophysiological and other clinical parameters.
- Trial name
- NCT01873950
- Testing
- Ranolazine, Dofetilide, Verapamil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Parental Language Behaviors
Thirty Million Words Project: A Feasibility Trial
The purpose of the proposed research is to evaluate the Thirty Million Words (TMW) Intervention through a randomized, controlled pilot study.
- Trial name
- TMW (NCT01754077)
- Testing
- LENA Linguistic Feedback Reports, Home Visiting Educational Session, Childhood Nutrition Education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain, Genetic Change
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in…
- Conditions
- Pain, Genetic Change, Children, Only
- Trial name
- NCT06777875
- Where
- Lebanon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Obesity, Overweight
A Maintenance Program for the Be Fit Employee Wellness Program
This research study is being done: 1) to determine if the MGH Be Fit program helps employees to change their nutrition and exercise habits and lower their risk for chronic diseases, such as heart disease and diabetes and 2) to…
- Trial name
- NCT00707577
- Testing
- Internet-based maintenance program
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Healthy
Study to Compare How the Body Changes the Blood Level of Darifenacin Tablet Form vs. the Modified Release Liquid Form in Healthy Subjects
This purpose of this study is to compare the how the body changes the blood level of a single dose of darifenacin when given as 7.5 mg modified release tablet and the modified release liquid suspension (1.5 mg/ml) under fasted…
- Trial name
- NCT00413426
- Testing
- Darifenacin (DAR328)
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Novartis
Osteopenia
A Comparison of Changes in Bone Density With the Same Bone-health Plan, But With Different Bone-health Supplements
A comparison of changes in bone density following the same bone-health plan, but with a different bone-health supplement.
- Trial name
- NCT01114685
- Testing
- AlgaeCal-1, AlgaeCal-2
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
HIV Infections, Menopause
Metabolic and Psychological Changes Associated With Menopause Among Women With HIV
This study will investigate the prevalence and extent of both metabolic and psychosocial changes associated with the menopause transition over 1 year among women with HIV compared to women without HIV of similar age, weight…
- Trial name
- NCT01142817
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Low Risk Pregnant Women, Climate Change Awareness
Climate Change Educational Program
Climate changes are the term used to describe the gradual rise in global temperatures, mostly accelerated by human activities. Climate changes are severe health emergency and considered the biggest threat to global health in the…
- Trial name
- NCT07743840
- Testing
- climate change educational program
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Assiut University
Glaucoma, Open-Angle, Glaucoma Secondary
Assessment of Effectiveness Ex-Press Surgery Modification
The purpose of the study is to compare the effectiveness and safety profile of ExPress implantation versus partial deep sclerectomy combined with ExPress implantation with simultaneously phacoemulsification.
- Conditions
- Glaucoma, Open-Angle, Glaucoma Secondary, Glaucoma, Primary Open Angle
- Trial name
- NCT03800589
- Testing
- phacoemulsification with implantation of the Ex-Press, deep sclerectomy, phacoemulsification, ExPress implantation
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Military Institute od Medicine National Research Institute
Hip Fractures
Treatment of Sub-capital Fractures of Hip Joint by Using TriboFit™ Acetabular Buffer
The purpose of this study is to determine the performance and efficacy during 6 and 12 month post operation. 1. determine changes in patient pain level 2. determine changes in patient functionality 3.
- Trial name
- NCT00663468
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Phoenix Kinetics
Atopic Dermatitis
In-home Use Test of the New Modified Diprobase Formulation to Assess the Safety and Tolerability in Infants and Children Under Physician's Control
To investigate the safety and tolerability of the modified Diprobase formulation over 14 days in infants and children with a history of Atopic Dermatitis (AD).
- Trial name
- NCT03441568
- Testing
- Modified Diprobase formulation (BAY987534)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bayer
Obesity Prevention, Obesity and Overweight
Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project
The goal of the HealthyW8 study (an intervention study) is: To assess the usefulness and effects of a digital-based healthy lifestyle recommender system (HRLS) on the prevention of obesity in the following propulations…
- Conditions
- Obesity Prevention, Obesity and Overweight, Obesity and Obesity-related Medical Conditions, Digital Health
- Trial name
- HealthyW8 (NCT07011368)
- Testing
- Intervention Group
- Where
- 13 sites in Bulgaria, Denmark and 6 more
- Volunteers
- 2,720 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Maternal Obesity, Gestational Weight Gain
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Obesity is a serious and increasing health problem in the Western World with about one third of all pregnant women in Denmark being overweight. Among these are more than 11% severe obese.
- Conditions
- Maternal Obesity, Gestational Weight Gain, Obstetric Complications
- Trial name
- LiP (NCT00530439)
- Testing
- Lifestyle intervention, Control, Physical activity, dietetic counselling
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Spinal Cord Injury
Longitudinal Morphometric Changes Following SCI
In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their…
- Trial name
- NCT02149511
- Where
- Switzerland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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