Clinical trials: Modification
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Dental Caries
Bioactive Composite Versus Resin-Modified Glass Ionomer Liners: 2-Year Clinical Trial
compare 2-year clinical performance of recent bioactive ionic resin composite to resin-modified glass ionomer liner in indirect dental pulp treatment.
- Trial name
- BIRCRMGILYCT (NCT05470959)
- Testing
- ACTIVA bioactive, Riva LC
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
High Blood Pressure, MTHFR C677T Genotype
Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype
Hypertension, which results from a combination of multiple lifestyle and genetic factors, is a global public health problem affecting 1 billion people worldwide.
- Trial name
- RiboBP (NCT03151096)
- Testing
- Riboflavin
- Where
- The Gambia
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Weight Gain
Promoting Healthy Weight Gain During Pregnancy
Study goal is to determine whether behavioral lifestyle intervention during pregnancy can reduce the number of women who exceed the Institute of Medicine recommendations for weight gain during pregnancy.
- Trial name
- NCT01117961
- Testing
- Lifestyle
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Maternity, Pregnancy
Passive Leg Raising in Term Pregnancy on Hemodynamic Monitoring - Validating With Transthoracic ECHO (LG-ECHO)
This prospective observational validation study aims to evaluate the agreement and diagnostic accuracy of ClearSight™ compared with transthoracic echocardiography (TTE) during PLR in term pregnant women.
- Conditions
- Maternity, Pregnancy, Labor and Delivery, Hemodynamic Changes
- Trial name
- (LG-ECHO) (NCT07253818)
- Testing
- ClearSight™ System, Transthoracic Echocardiography, Passive Leg Raising (PLR) Maneuver
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ayse Zeynep Turan Civraz
Temperature Change, Body
Skin Temperature Changes When Using a Cryocompression Device
Cryotherapy after surgery is widely utilised and has numerous practical applications for post-operative rehabilitation. Previous research has suggested that during cold therapy, the skin temperature of the knee should be reduced…
- Trial name
- NCT05136482
- Testing
- Cryocompression
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Smoking
Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement Setting
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 consecutive days by adult Japanese healthy smokers affects the levels of biomarkers of exposure for selected…
- Trial name
- NCT01970982
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Japan
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Immediate Implant
Immediate Implant Placement With Sticky Tooth Versus Autogenous Tooth Graft In Cases With Labial Plate Dehiscence
Evaluation of Soft and Hard Tissue Changes After Immediate Implant Placement With Sticky Tooth Versus Autogenous Tooth Graft for management of Cases With Labial Plate Dehiscence
- Trial name
- NCT05891990
- Testing
- immediate implant augmented with sticky tooth, immediate implant augmented with autogenous tooth graft
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Halla Gamal Mohammed Esmail
Alzheimer Disease
A Study on the Effectiveness of Multidomain Intervention Program for Reducing Risks of Dementia
Investigators aimed to examine the feasibility and effectiveness of a multidomain intervention strategy involving intensive and maintenance programs aimed at reducing the risk of Alzheimer's disease (AD) in at-risk older adults.
- Trial name
- NCT03786510
- Testing
- Active control, Intensive + Maintenance program, Intensive program only
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sedentary Behavior
Behavior Change Techniques (BCTs) to Improve Low Intensity Physical Activity in Older Adults
The purpose of this pilot study is to determine the feasibility of using personalized trial methods in a virtual research study with Northwell employees aged 45-75 years old to increase low-intensity walking by 2,000 steps per…
- Trial name
- NCT04967313
- Testing
- Behavioral Change Techniques
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Dietary Modification
Meat and Whey Protein Supplementation in Athletes
The aim of this project is to investigate the potential benefits of combining a new protein meat hydrolysates extract with a regular resistance training programme on (a) body composition (b) performance (c) muscle structure (d)…
- Trial name
- NCT02425020
- Testing
- Meat Protein, Whey protein, Carbohydrate
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Sleep Duration, Athletic Performance
Delayed Morning Training, Sleep, and Change-of-Direction Performance in Badminton Athletes
This randomized controlled trial will investigate whether delaying the start of morning training from 7:00 AM to 9:00 AM improves nocturnal sleep and change-of-direction performance in elite badminton athletes.
- Trial name
- NCT07873203
- Testing
- Usual Morning Training Schedule, Delayed Morning Training Schedule
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Capital University of Physical Education and Sports, China
PreDiabetes, Obesity
WorkWell: Work-based Activity and Metabolic Health
This study will test whether a range of pre-clinical cardiometabolic biomarkers can be improved via regular intervals of standing and light-intensity physical activity in real-world office environments.
- Trial name
- NCT04269070
- Testing
- Standing condition, Light physical activity (LPA) condition, Usual behavior condition
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Myopia, High, With Cataract and Anterior Capsule Polished
The Influences Of Anterior Capsule Polishing On Anterior Capsular Changes and Intraocular Lenses Stability of Super High Myopic Eyes
A prospective study included 20 patients with super high myopia who underwent bilateral uneventful cataract. 360°anterior capsule polishing was performed with double-ended capsule polisher randomly in one eye, and the opposite…
- Trial name
- NCT03142269
- Testing
- 360°anterior capsule polishing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- yin ying zhao
Isolated Anterior Cruciate Ligament Rupture
Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction
The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT01537588
- Testing
- Autograft STG harvest from ACL-deficient leg, Autograft harvest contralateral to ACL-deficient leg
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Panam Clinic
Domestic Violence, Domestic Abuse
Communication Skills vs. Mindfulness for IPV
This tests the immediate impact of two brief interventions on couples reporting intimate partner violence using the proximal change experimental design.
- Conditions
- Domestic Violence, Domestic Abuse, Family Conflict, Aggression
- Trial name
- NCT03672942
- Testing
- Communication Skills Training, Mindfulness
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Houston
Papillomavirus Infections, Papillomavirus Vaccines
Intervention for Human Papillomavirus Vaccine Acceptance in Mexican Mothers
Randomized clinical trial with two groups, with a test-retest model, with single-blind approach, using a probabilistic sampling and the population was mothers of girls aged 9 to 12 years from a public elementary school in the…
- Trial name
- NCT06854354
- Testing
- HPV Prevention Vaccine
- Where
- Mexico
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital Univeristario Benemerita Universidad Autonoma de Puebla
Well-Being, Psychological, Digital Skills
Older People, New Needs, and Possible Solutions. A Pilot Study on Peer-to-peer Digital Education
"Older people, new needs, and possible solutions: A pilot study on peer-to-peer digital education" aims to create a digital literacy protocol targeted specifically to older people, providing them with the digital skills needed to…
- Trial name
- NCT06510959
- Testing
- Digital course
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
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