Clinical trials: Modification
Pregnancy
Study of Changes in the Feet With Pregnancy
This research is being conducted to determine whether use of an arch-supporting insole during pregnancy prevents alterations in foot structure and lower limb rotational movements.
- Trial name
- NCT01868074
- Testing
- Insole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cataract
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
The EpiGlare Tester will identify visual disability resulting from the glare experienced by subjects with cataracts in the glare-induced change in best spectacle corrected visual acuity (BSCVA).
- Trial name
- NCT04739397
- Testing
- Glare Testing
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Epico, LLC
Cardiac Output, Low
Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia
The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery.
- Trial name
- EPhON (NCT03421860)
- Testing
- cardiac output changes with "ephedrine", cardiac output changes with "phenylephrine", cardiac output changes with "ondansetron"
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
PHYSIOLOGICAL PHENOMENA, Homeostasis
Truway Whole-Body Digital Twin and Physiologic Resilience Study (TRU-OMNIBODY)
TRU-OMNIBODY is a prospective observational study designed to develop and independently validate a research-only whole-body digital twin.
- Conditions
- PHYSIOLOGICAL PHENOMENA, Homeostasis, Physical Functional Performance, Cardiorespiratory Fitness
- Trial name
- TRU-OMNIBODY (NCT07805044)
- Testing
- Standardized Physiologic Resilience Challenge, Multimodal Whole-Body Physiologic Monitoring, Research-Only Whole-Body Digital Twin Analysis
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Obesity & Overweight
Ultra-processed Food Consumption and Health Pilot Study
The objective of this study is to explore the effects of two dietary conditions (UPF-diet and typical American diet) on a number of clinical and metabolic outcomes in order to derive sample size estimates for a larger trial and…
- Trial name
- ULTRA PIlot (NCT07318064)
- Testing
- Purple Diet, Ultra-processed diet
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Breast Cancer
The Effect of Mindfulness-based Yoga and Meditation on Some Parameters in Breast Cancer Patients
The purpose of this study was to evaluate the effect of mindfulness-based meditation and yoga on stress, self-esteem, body image and sexual adjustment in breast cancer patients.
- Trial name
- NCT06110832
- Testing
- Mindfulness-based Meditation and Yoga program
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Class II Division 1 Malocclusion
Effect of Modified Twin Block in Skeletal Class II Growing Females With Mandibular Deficiency
The aim of this study is to evaluate the treatment effects of conventional twin block appliance versus modified twin block appliance in the treatment of patients in growing stage having skeletal class II division 1 with…
- Trial name
- NCT03635463
- Testing
- twin block appliance, modified twin block appliance
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulmonary Arterial Hypertension
Repeatability and Sensitivity to Change of Non-invasive Endpoints in PAH
Pulmonary arterial hypertension (PAH) is progressive life limiting disease with a median survival of less than 3 years without treatment.
- Trial name
- RESPIRE (NCT03841344)
- Testing
- MRI
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Exosomes, Connective Tissue
Exercise-induced Changes in Exosomes
The proposed study aims to shed light on the function/importance/relevance of exercise-induced changes in exosomes to connective tissues. Exosomes are known to increase robustly in response to exercise.
- Conditions
- Exosomes, Connective Tissue, Exercise
- Trial name
- NCT05616234
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Primary Open Angle Glaucoma
Electroretinogram and Retinal Vascular Changes After Cataract Surgery
To compare electrophysiological and Optical coherence tomography angiography of optic disc and macula changes after uneventful phacoemulsification between normal and cataractus patients with primary open angle glaucoma.
- Trial name
- NCT05871034
- Testing
- phacoemulsification
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cognitive Change, Health Behavior
A Multidomain Approach to Preventing Dementia in African Americans: Cognitive Prescriptions
The goal of this R21 study is to explore the feasibility and preliminary efficacy of individualized cognitive prescriptions (CogRxs) in improving engagement in healthy behaviors and other outcomes in middle-aged AAs and to gain…
- Conditions
- Cognitive Change, Health Behavior, Health Literacy
- Trial name
- NCT03864536
- Testing
- Cognitive Prescriptions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Smoking Behaviors
Effect of Oral pH Changes on Smoking Desire
Nicotine is a psychoactive substance and its effect is demonstrated by neuronal nicotinic-acetylcholine receptors excreted in the brain and periphery.
- Trial name
- NCT04032236
- Testing
- caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Physical Activity, Diet Modification
Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function
Prolonged sitting has been shown to impair metabolism and vascular function. The overall purpose of this study is to determine if breaking up prolonged (9 hours) of sitting with brief (~20 second) stair climbing exercise "snacks"…
- Trial name
- NCT03374436
- Testing
- High-Carbohydrate Sedentary, High-Carbohydrate Active, Low-carbohydrate Sedentary
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alcohol Abuse, Drug Use
The Weaving Healthy Families Program
Alcohol and other drug (AOD) abuse and violence in families are co-occurring risk factors that drive health disparities and mortality among Native Americans (NA), making the long-term goal of this research is to promote health…
- Conditions
- Alcohol Abuse, Drug Use, Violence, Domestic, Child Abuse
- Trial name
- NCT03924167
- Testing
- Weaving Healthy Families Program
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tulane University
Eating, Time Restricted, Cognitive Change
The Efficacy of Proper Breakfast Times on Cognitive Function
The goal of this cluster randomized controlled trial is to learn if a proper breakfast time may increase cognitive function. It will also learn about the effectiveness of proper breakfast time on health outcomes.
- Conditions
- Eating, Time Restricted, Cognitive Change, Blood Pressure, Nutrition, Healthy
- Trial name
- NCT06541392
- Testing
- breakfast 6.30 am, breakfast 7.31 am
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Muhammadiyah Aceh
Tooth Sensitivity
Evaluation of Sensitivity and Color Change of Different Protocols of In-office Dental Bleaching
Clinical randomized single-blind trial, used to measure the level of tooth sensitivity (TS) after in-office dental bleaching sessions, on volunteers using a modified visual analog scale (VAS).
- Trial name
- NCT07597044
- Testing
- Standard in-office tooth bleaching, Alternative in-office tooth bleaching
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Changes in Knee Measurements Between Egyptian and Western Population
Knee Posterior Femoral Condylar Offset and Tibial Slope of the Egyptian Population
this study is to compare the posterior condylar offset , posterior condylar offset ratio and tibial slope of Egyptian population with Asian and Western results.These results may be important to examine if contemporary total knee…
- Trial name
- knee (NCT03622034)
- Testing
- posterior condylar offset measurement
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Prediabetes, Weight Loss
Diabetes Prevention Through Genetics, Familial History and Behavior Change
The goal of this clinical trial is to learn if adding a family engagement component to the standard Diabetes Prevention Program (DPP) improves outcomes for adults with prediabetes.
- Trial name
- NCT07815236
- Testing
- LEGACY DPP, DPP
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
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