Clinical trials: Modification
Corneal Deformity, Macular Degeneration Advanced
Comparison of Ocular Changes by Surgical Menopause Using Optical Coherence Tomography (OCT)
The aim of this study is to investigate the early changes in macular thickness, corneal thickness and intraocular pressure in young women undergoing surgical menopause.
- Conditions
- Corneal Deformity, Macular Degeneration Advanced, Surgical Menopause
- Trial name
- NCT05920655
- Testing
- Optic coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Batman Training and Research Hospital
Healthy
Changes in Sensory Perception During Hypnotic Relaxation
Changes in sensory thresholds and pain thresholds will be measured with quantitative sensory testing (QST) before and during hypnotic relaxation in healthy volunteers. Hypnotic susceptibility will be assessed before QST.
- Trial name
- NCT02261155
- Testing
- Hypnosis
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Stability of Clavicular Fractures Within the First 3 Weeks
Clavicular Shortening Post-fracture - Does it Change? - a Prospective Study of 70 Patients
In an attempt to answer if clavicular length changes after a fracture e.g. that any shortening becomes worse or better, 70 patients will be followed 3 times over 21 days using a novel ultrasound method.
- Trial name
- NCT02089282
- Testing
- Ultrasound
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Dietary Modification
Assessment of Different Forms of Creatine
The purpose of this study is to examine the pharmacokinetics of creatine nitrate supplementation.
- Trial name
- NB3 (NCT03000582)
- Testing
- Creatine monohydrate, Creatine nitrate-1, Creatine nitrate-2
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Plantar Foot Pressure
Pedobarographic Changes After Forefoot Reconstruction
Static pedobarography is routinely used for pre- and postoperative questions regarding plantar foot pressure. This Investigation does insufficiently detect dynamic Forces.
- Trial name
- PEDfore (NCT02643485)
- Testing
- Forefoot surgery
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Hypothermia
Study of Heat and Intravenous Fluids for Exogenous Rewarming
The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with…
- Trial name
- SHIVER (NCT02339103)
- Testing
- Warmed IV fluids, Warmed perfusion pads
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University
Intestinal Diseases
Microbiome Changes in Travelers to Tropical Destinations
The human gut contain a wide range of microorganisms creating the gut microbiome. The microbiome has great impact on metabolic and immunologic processes and responses.
- Trial name
- NCT02295254
- Testing
- feces sample
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Healthy Participants
The Change in Cutaneous Temperature When Using Acupuncture at TB-3 and BL-65 Acupoints in Healthy Participants
For more than 2,500 years, traditional medicine, especially acupuncture, has been widely used in health care and recognized by the World Health Organization (WHO) to manage various diseases.
- Trial name
- NCT06200337
- Testing
- Fine needle acupuncture
- Where
- Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loc Cong Dai Tran, MD
Fever, Sore Throat
Thermographic Characteristics of Sore Throat by Thermographic Camera
Thermographic cameras are used to determine temperature and temperature differences. Attempts have been made to use the thermographic camera as a diagnostic tool in clinical practice.
- Trial name
- thermography (NCT01782183)
- Testing
- Thermal camera by Flir -HM series.
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Doron Carmi
Sjogren's Syndrome, Dry Eye
Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease
This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye.
- Trial name
- JADE (NCT00809003)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Cognitive Change, Mood Change
Cognitive Effects of Sage in Healthy Humans
Extracts of sage and polyphenols have separately been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has combined these interventions.
- Trial name
- NCT03695003
- Testing
- Cognivia
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Chronic Pain, Musculoskeletal Pain Disorder
Cognitive Bias Modification for Interpretation Individuals With Chronic Musculoskeletal Pain
Cognitive Bias Modification for Interpretation (CBM-I) trains participants to interpret ambiguous information as neutral or benign, rather than interpret it as being related to pain.
- Trial name
- NCT06368362
- Testing
- Benign cognitive bias modification for interpretation, Pain-related cognitive bias modification for interpretation
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Obesity, Weight Loss
Protein Supplementation Intervention on Body Weight
This study is a randomized clinical trail with a parallel design, involving 120 overweight/obese (body-mass index, BMI ≥ 24 kg/m²) participants and 20 normal-weight participants.
- Conditions
- Obesity, Weight Loss, Protein Supplementation
- Trial name
- NCT06989203
- Testing
- General lifestyle and nutritional education, Calorie-restricted balanced diet, semaglutide
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Healthy
To Assess the Effect of the Special Condition on the Pharmacokinetics and Tolerability of the Esflurbiprofen Topical System (EFTS) in Healthy Volunteers.
This study is a single-center, open-label, single-dose trial performed in a randomized, four-way, change-over design in healthy volunteers.
- Trial name
- NCT06870422
- Testing
- Esflurbiprofen Topical System
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Cicatrix, Wound Healing
Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects
The purpose of this study is to further determine the safety and toleration of intradermal avotermin (Juvista), confirm accelerated healing and investigate genomic expression profiles
- Trial name
- NCT00977951
- Testing
- Intradermal avotermin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Renovo
Peri-Implant Papilla Deficiency
Modified Labial Pedicle Papilla Flap (mLPPF) With or Without De-epithelialized Gingival Graft (dGG) for Peri-implant Papilla Reconstruction
This randomized controlled clinical trial aims to evaluate the effectiveness of two surgical techniques for peri-implant papilla reconstruction in single-tooth implants in the maxillary anterior and premolar regions.
- Trial name
- mLPPF-dGG (NCT07204353)
- Testing
- Papilla-preserving incision (Control), Modified Labial Pedicle Papilla Flap (mLPPF), Modified Labial Pedicle Papilla Flap with De-epithelialized Gingival Graft (mLPPF+dGG)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cuneyt Asim Aral
Double-blind Design, Sham-controlled
Neurostimulation in Chronic and Episodic Migraine
Currently, successful prevention of migraine is not sufficiently achieved by (prophylactic) drug therapy. In contrast, neurophysiologically guided treatments might provide an alternative avenue, since these can normalize brain…
- Conditions
- Double-blind Design, Sham-controlled, Randomized
- Trial name
- NCT03237754
- Testing
- tDCS device from neuroConn
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Genetic Screening, Adolescent
Engaging Adolescents in Decisions About Return of Genomic Research Results
Recent recommendations to return children's results for adult-onset conditions to parents anytime whole exome or genome sequencing is performed, as well as growing expectations to return research results to participants on a…
- Conditions
- Genetic Screening, Adolescent, Genetic Change, Shared Decision Making
- Trial name
- NCT04481061
- Testing
- Electronic Decision Tool
- Where
- 2 sites in United States
- Volunteers
- 787 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diet Modification
Women's Responses to Adjusted Product Placement and Its Effects on Diet - 1 (WRAPPED1)
This research project aims to help address a gap in understanding about the micro-environmental determinants of diet by exploring whether improving the placement of fresh and frozen fruit and vegetables and removing temptations…
- Trial name
- WRAPPED1 (NCT03518151)
- Testing
- Product placement intervention
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
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