Clinical trials: Modification
Coronary Artery Disease
Hemodynamic Changes in Off-pump Coronary Artery Bypass Grafting
The purpose of this study is to study the positioning and stabilization of different cardiac walls performed during off-pump coronary artery bypass grafting (CABG) may have dissimilar impact on hemodynamics.
- Trial name
- NCT00967278
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
Comparison of Plasma Concentration Changes Between Two Types of Tablets of FK949E Administration to Patients With Major Depressive Disorder
This study is to compare the pharmacokinetics of FK949E low dose tablets and FK949E high dose tablets in non-elderly patients with major depressive disorder. The safety of FK949E in the population was also evaluated.
- Trial name
- NCT01919008
- Testing
- FK949E
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Astellas Pharma Inc
Gestational Weight Gain
Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women
The purpose of this study is to investigate the reference ranges and rates of gestational weight gain among Chinese pregnant women, and to analyze the correlation between gestational weight gain and adverse outcomes.
- Trial name
- GWGCPW (NCT03154268)
- Volunteers
- 10,422 people
- Sponsor
- West China Hospital
Central Serous Chorioretinopathy
Central Serous Chorioretinopathy Treated by Modified Photodynamic Therapy
The purpose of this study is to evaluate the effectiveness as well as the detrimental influence of half-dose and half-fluence modification of verteporfin photodynamic therapy (PDT) for the treatment of prolonged unresolved…
- Trial name
- NCT01019668
- Testing
- Verteporfin PDT, half-dose, verteporfin PDT, half-fluence
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Movement Disorders, Heathly Subjects
Changes in the Posterior Parietal Cortex - Primary Motor Cortex Pathway Induced by Motor Training
Objective When learning to tap to a rhythm the brain has to coordinate information from different senses (eyes, ears, touch). This information has to be integrated into a movement plan to allow a smooth, continuous performance.
- Trial name
- NCT00904332
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Covid19, SARS-CoV-2
Changes in Cellular Immune Profile During COVID-19 Infection
Clinical specimens are collected from individuals either recovered from or with active SARS-CoV-2 infection to support process and analytical development for a potential cell-based immunotherapy in preclinical research…
- Trial name
- NCT04470999
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Serhat Gumrukcu, MD PhD
Myofascial Pain
Ultrasonographic Assessment of Muscle Echogenicity in Myofascial Pain
Myofascial pain is one of the most important symptoms in patients with temporomandibular disorders (TMD). Although the etiological factors leading to TMD have not been definitively established, parafunctional habits such as…
- Trial name
- UAMEMP (NCT07676799)
- Testing
- occlusal splint, Lidocaine Hydrochloride 2% Injection Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Cognitive Change
Effect of Obstructive Sleep Apnea on Glucose Control and Cognitive Function
Obstructive sleep apnea (OSA) may contribute to altered cognitive function in patients suffering from severe OSA. And lifestyle modification program may improve the cognitive function after 6 months of therapy.
- Trial name
- NCT05108363
- Testing
- Lifestyle modification program
- Where
- China
- Sponsor
- Chinese University of Hong Kong
Arteriosclerosis, Osteoporosis
An Open Clinical Trial to Assess the Influence of Newly Prescribed Aminobiphosphonates on Arterial Stiffness
The study tries to reveal if aminobisphosphonates influence aside the bone density also the vascular status in the typical elderly patient population
- Trial name
- NCT00180232
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Sleep Deprivation, Military Activity
Can Ammonium Inhalants Maintain Performance in Sleep Deprived Soldiers?
This study aims to examine the effectiveness of ammonia inhalants in countering the effects of total sleep deprivation on cognitive and physical performance tests relevant to military personnel.
- Conditions
- Sleep Deprivation, Military Activity, Sleep, Cognitive Change
- Trial name
- NCT05868798
- Testing
- Ammonia Inhalant
- Where
- Czechia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jan Malecek
Cachexia; Cancer, Muscle Wasting
Muscle Wasting in Children and Adolescents With Cancer
The series of the 3-year study aims to explore parents' experience of caring for a child's weight change among parents of children and adolescents with cancer, examine the associations and trends among muscle wasting and…
- Conditions
- Cachexia; Cancer, Muscle Wasting, Child Development, Adolescent Development
- Trial name
- NCT04353063
- Testing
- Multidisciplinary care with a personalized care
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- National Taiwan University Hospital
Tobacco Use, Smoking Cessation
The Effect of Motivational Interviewing on Smoking Behavior Among Nursing Students
Smoking is one of the leading preventable public health problems worldwide, particularly among young adults who are at increased risk of nicotine dependence.
- Trial name
- NCT07758998
- Testing
- Transtheoretical Model-Based Motivational Interviewing
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Meral Feratoğlu Research
Upper Limb Exclusion Syndrom
Changes in Tactile Perception in People With Segmental Exclusion Syndrome
Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system.
- Trial name
- NCT05650398
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Nephrotic Syndrome, Focal Segmental Glomerulosclerosis
Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)
The purpose of this study is evaluate if abatacept is effective and safe in decreasing the level of protein loss in the urine in patients with excessive loss of protein in the urine (nephrotic syndrome) due to either focal…
- Conditions
- Nephrotic Syndrome, Focal Segmental Glomerulosclerosis, Minimal Change Disease
- Trial name
- NCT02592798
- Testing
- Abatacept, Normal Saline, D5W
- Where
- 27 sites in United States
- Volunteers
- 36 people
- Sponsor
- Bristol-Myers Squibb
Hypothermia
Does Environmental Factors Affect Accuracy in Pre-hospital Non-invasive Temperature Measurement?
The aim of this study is to assess the impact of different environmental factors on the ability for a thermistor-based epitympanic thermometer to accurately read the temperature of a normothermic individual and thereby estimate…
- Trial name
- NCT02274597
- Testing
- metraux epitympanic thermometer
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Malignant Glioma
Study of Capecitabine to Treat Recurrent High Grade Gliomas
The purpose of this study is to determine if capecitabine is effective in the treatment of high grade gliomas that have returned after completing treatment.
- Trial name
- NCT00717197
- Testing
- Capecitabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Colorectal Neoplasms, Neoplasm Metastasis
Study of Aflibercept And Modified FOLFOX6 As First-Line Treatment In Patients With Metastatic Colorectal Cancer
The primary objective of the study is to estimate the progression-free survival rate at 12 months for the two arms of the study.
- Trial name
- AFFIRM (NCT00851084)
- Testing
- aflibercept, oxaliplatin, 5-FU
- Where
- 37 sites in Australia, Germany and 5 more
- Volunteers
- 268 people
- Sponsor
- Sanofi
Infections, Streptococcal
Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment
The aim of the current study is to determine whether ibuprofen, given as immediate or delayed prophylactic antipyretic treatment in a standardized manner, significantly impacts the immune response in children receiving primary…
- Trial name
- NCT01235949
- Testing
- GSK1024850A (SynflorixTM), Infanrix hexa, Infanrix-IPV/Hib
- Where
- 23 sites in Romania
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Overactive Bladder
A Study to Evaluate Once Daily Low Dose and High Dose Solabegron or Placebo Given for 12 Weeks to Treat Women With Symptoms of Overactive Bladder: Sudden Urge to Urinate, Frequent Urination Associated With Wetting Episodes (VEL-2001)
This is a Phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group study designed to evaluate the efficacy, safety, and tolerability of solabegron modified release low dose or high dose tablets…
- Trial name
- VEL-2001 (NCT03594058)
- Testing
- Solabegron modified release tablets, low dose, Solabegron modified release tablets, high dose
- Where
- 77 sites in United States
- Volunteers
- 1,413 people
- Sponsor
- Velicept Therapeutics, Inc.
Nephrotic Syndrome in Children, Focal Segmental Glomerulosclerosis
NEPTUNE Match Study
NEPTUNE Match is an additional opportunity offered to NEPTUNE study participants to prospectively recruit and communicate patient-specific clinical trial matching with kidney patients and their physician investigators.
- Conditions
- Nephrotic Syndrome in Children, Focal Segmental Glomerulosclerosis, Minimal Change Disease, Minimal Change Nephrotic Syndrome
- Trial name
- NEPTUNE Match (NCT04571658)
- Testing
- Communication
- Where
- 16 sites in United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan
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