Clinical trials: Modification
Coronary Artery Disease
Effect of Intraoperative Arterial Oxygen Targets on Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin
This single-center randomized trial compared two intraoperative arterial oxygen tension (PaO2) target strategies in adults undergoing elective isolated coronary artery bypass graft surgery.
- Trial name
- NCT04627220
- Testing
- Intraoperative Oxygenation Strategy: PaO2 200 mmHg or Greater, Intraoperative Oxygenation Strategy: PaO2 80 to Less Than 200 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Hypothermia
Study of a New Clinical Device for Reducing Body Core Temperature
This is a descriptive, nonrandomized, noninvasive, single-group, single-center pilot study of a Core Cooling System (CCS) device for reducing core body temperature in ICU patients at University Medical Center Brackenridge (UMCB)…
- Trial name
- NCT01996982
- Testing
- CCS Device
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Seton Healthcare Family
Retinopathy of Prematurity, Myopia
Prematurity and Ophthalmological Changes
Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
- Trial name
- NCT06452524
- Testing
- axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Hypertension
Management of Uncontrolled Hypertension (HTN)
In this study, investigators will compare chronotherapy to ABPM. Data collected will include hypertension drug therapy regimen prior to and during the study, timing of medication administration, and dose, along with the patient's…
- Trial name
- NCT02922023
- Testing
- Ambulatory blood pressure monitor (ABPM), Chronotherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Hospitalization
Adapted Physical Activity, Health-related Quality of Life and Satisfaction With Care in Hospitalized Children
The aim of this study is to assess the efficacy of adapted physical activity intervention on health-related quality of life and satisfaction with care in hospitalized children and adolescents.
- Trial name
- ACTIVHOP (NCT00828217)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 312 people
- Sponsor
- Central Hospital, Nancy, France
Adverse Effects
A Prospective Study to Assess Metabolic Changes in Children and Adolescents Treated With Atypical Antipsychotics
The purpose of this study is to observe patients aged 6-18 with various psychiatric diagnosis being treated with drugs called atypical antipsychotics to determine the effects of the drugs on growth, weight gain, and laboratory…
- Trial name
- NCT00480168
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Weight Loss
Single Arm Trial of a Multi-component Commercial Digital Weight Loss Program
The goal of the proposed research project is to evaluate the acceptability and efficacy of an online multicomponent commercial weight loss program and to understand the relationship between program engagement and weight loss and…
- Trial name
- NCT04302389
- Testing
- myWW App, Virtual Workshops, and Private Facebook Group
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
STEMI, Quality Indicators
CP4ACS - Delphi Study to Determine Appropriateness of STEMI Quality Indicators in Belgium
RAND/UCLA modified Delphi study on quality indicators for STEMI to determine the appropriateness of quality indicators retrieved from literature and guideline review.
- Trial name
- NCT02030210
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- European Pathway Association
Health Behavior
Hans Kai: Impact of a Peer Lead Community Health Program on Behavior Change, Mental Health, Health Efficacy and Social Support Comparative Control Study
To study the difference between participants interested in a lifestyle change when enrolled in Hans Kai or not when comparing behaviour change, social support, self health efficacy and mental health.
- Trial name
- NCT03450382
- Testing
- Hans Kai Education
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- NorWest Co-op Community Health
Bimaxillary Protrusion
Effect of an AI Prediction Model of Facial Changes After Orthodontic Treatment of Patients With Bimaxillary Protrusion
After developing an Artificial Intelligence model to predict the facial changes of patients with bimaxillary protrusion following orthodontic extraction of premolars and tooth retraction, participants will view a prediction in…
- Trial name
- Ai (NCT07066423)
- Testing
- Ai prediction photo of the patients, Fixed orthodontic brackets with premolars extraction
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Ischemic Heart Disease Chronic, Diabetes Mellitus, Type 2
Lifestyle Intervention in Chronic Ischemic Heart Disease and Diabetes
Chronic ischemic heart disease and diabetes mellitus type II have one of the highest morbidity and mortality rates. Especially in the presence of both diseases, these risks increase exponentially.
- Trial name
- LeIKD (NCT03835923)
- Testing
- lifestyle intervention, usual care
- Where
- 10 sites in Germany
- Volunteers
- 502 people
- Sponsor
- Techniker Krankenkasse
Weight Loss
Orbera365 Intragastric Balloon System (Abbreviated as'Orbera365')
To demonstrate the safety and efficacy of Orbera365 in obese populations to support the registration of Orbera365.
- Trial name
- NCT07195708
- Testing
- Treatment group
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Boston Scientific Corporation
Obstructive Sleep Apnea-hypopnea Syndrome (OSAHS)
Study of the Effect of an Elastic Compression Medical Device, on Water Balance Change in Healthy Subjects
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by the occurrence of abnormally frequent episodes of interrupted ventilation (apnea) or significant reduction of ventilation (hypopnea) during sleep.
- Trial name
- NCT04911725
- Testing
- Elastic Compression Prototype
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Laboratoires Innothera
Non-Alcoholic Fatty Liver Disease, Obesity, Morbid
Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
The study is aimed To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease
- Trial name
- NCT03875625
- Testing
- Bariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Coronary Disease, Weight Loss
Time Restricted Feeding for Weight Loss and Cardio-protection
Time restricted feeding (TRF) is a novel form of intermittent fasting that involves confining the period of food intake to 8 h/d (e.g. 10 am to 6 pm) without calorie counting.
- Trial name
- NCT02948517
- Testing
- Time restricted feeding
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV Infections
Evaluating Inflammatory and Immunological Changes of HIV-positive Patients Switching to DTG Dual Regimen Compared to Those Switching to a Triple Drugs Regimen (B/F/TAF)
Long-term side effects of antiretrovirals (ART) have led to the introduction in clinical practice of NRTI-sparing regimens as double- or mono- therapy and their use is now recommended in specific populations by International…
- Trial name
- NCT04054089
- Testing
- Bictegravir 50 MG / Emtricitabine 200 MG / Tenofovir Alafenamide 25 MG [Biktarvy], dolutegravir 50 mg / lamivudine 300 mg
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Cristina Mussini
Insulin Sensitivity
Gene - Diet Interactions
Interactions between genes and environment, i.e. our inherited responses to environmental changes, may be crucial in the development of the common diseases.
- Trial name
- Genediet (NCT01274091)
- Testing
- PUFA-diet, SAFA-diet
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Condition or Focus of Study: Pregnancy
Effects of Climate Change Education on Pregnant Women
Aim: This study aimed to evaluate the effect of climate change education provided to pregnant women on climate change awareness, climate change anxiety, and psychosocial health.
- Trial name
- NCT07903818
- Testing
- Climate Change Education
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dicle University
Nephrosis, Lipoid
Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study
Study objective: To investigate the potential therapeutic efficacy of enteric-coated mycophenolate sodium combined with low-dose corticosteroid as first-line treatment for minimal change nephrotic syndrome (MCNS).
- Trial name
- NCT01185197
- Testing
- Myfortic plus low-dose steroid, Prednisolone
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Analgesic Efficacy of M-TAPA Block Accomplished Prior to Surgery in Patients Undergoing Laparoscopic Gynecological Surgeries
Modified Thoracoabdominal Nerves Block Through Perichondrial Approach: a New Strategy With a Wide Range of Utilization in Laparoscopic Gynecological Surgeries.
The current study was to assess the analgesic effects of the modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) block in patients undergoing gynecological laparoscopic surgeries.The primary goal was to…
- Trial name
- NCT06039423
- Testing
- The M-TAPA block, Ketorolac
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
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