Clinical trials: Modification
Child Obesity
Efficacy of Nuts in Obese Children.
Obesity is a problem of ever-growing importance, especially in industrialized countries, both in adults and in the pediatric population.
- Trial name
- NCT03870984
- Testing
- wNUTS, low-caloric diet plus nuts, w/oNUTS, low-caloric diet without nuts
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Other Skin
Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer
This phase I/II trial studies the side effects of gene-modified immune cells (FH-MCVA2TCR) and to see how well they work in treating patients with Merkel cell cancer that has spread to other parts of the body (metastatic) or that…
- Trial name
- NCT03747484
- Testing
- Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR, Avelumab, Pembrolizumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Fred Hutchinson Cancer Center
Modified Fixed Bridge
3D Printed vs CAD/CAM Rehabilitation of Primary Anterior Teeth Loss
compare 3D Printed versus CAD/CAM fabricated modified fixed appliance for rehabilitation of premature loss of anterior teeth in preschool children
- Trial name
- NCT07752147
- Testing
- 3D Printed modified fixed bridge, CAD/CAM fabricated modified fixed bridge
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Children Under General Anesthesia
Study on Changes of Pulse Oximeter Plethysmographic Amplitude Induced by Respiration in Pediatric Patients
The purpose of this study is to evaluate the variations of respiratory changes in pulse oximeter plethysmographic amplitude (delta POP) according to different contact forces between finger and sensor of pulse oximeter.
- Trial name
- NCT02940938
- Testing
- Applying pulse oximeter sensor
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Weight Loss
Body Contouring Surgery After Massive Weight Loss
Body contouring (BC) surgery after major weight loss (MWL) requires extensive and multiple procedures. Yet, there are inconsistent data regarding the outcome after BC procedures.
- Trial name
- NCT02174458
- Testing
- Body Contouring Surgery
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Cachexia, Anorexia
Pharmacokinetics of Megace F and Megace OS Under Fasting and Fed Conditions in Healthy Male Volunteers
Phase I study of Megace F will be conducted to investigate pharmacokinetics and safety compared to Megace OS. Phase I study divided into 3 parts written as belows.
- Trial name
- MGF (NCT01397214)
- Testing
- Megace F, Megace OS
- Where
- South Korea
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Type 1 Diabetes
Exercise and the Menstrual Cycle in Type 1 Diabetes
Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during…
- Trial name
- NCT05188014
- Testing
- Luteal Phase Aerobic Exercise, Follicular Phase Aerobic Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Optic Neuritis
Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
This study examines the effect of vitamin D on Retinal changes in patient with optic Neuritis.
- Trial name
- NCT01465893
- Testing
- Vitamin D, Vitamin D withheld
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
HIV Infection
Enhancement of Connect to Protect® (C2P)
The proposed study seeks to continue Connect to Protect® (C2P) community mobilization efforts that have developed coalitions that plan for and bring about structural changes for purposes of reducing HIV incidence and prevalence…
- Trial name
- NCT01492816
- Testing
- Community Mobilization
- Where
- 9 sites in United States
- Volunteers
- 927 people
- Sponsor
- University of North Carolina, Chapel Hill
Alopecia Areata
Modified SALT Score for Alopecia Areata
Patchy Alopecia areata was treated by intralesional steroids for 3 months and was evaluated by percentage of involvement, mSALT score and dermoscopy.
- Trial name
- NCT04412148
- Testing
- Triamcinolone Acetonide, saline
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
Obesity, Weight Loss
Effects of Adding L-BAIBA to Exercising Adult Overweight and Obese Men and Women
Beta-amino isobutyric acid (BAIBA) is a myokine produced in skeletal muscle and has been shown to impact how our body metabolizes fuel.
- Conditions
- Obesity, Weight Loss, Weight, Body, Cardiometabolic Syndrome
- Trial name
- LBC (NCT05775016)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Cardiovascular Disease
Omacor and Placebo in Carotid Plaque Stability
The purpose of this study is to investigate the effect of intake of Omacor (Omega-3-acid ethyl ester 90) 2g/day on specified parameters related to the stability of carotid plaque in patients awaiting endarterectomy.
- Trial name
- NCT00294216
- Testing
- Omega-3-acid ethyl ester 90 (n-3 PUFA)
- Where
- United Kingdom
- Volunteers
- 121 people
- Sponsor
- Pronova BioPharma
Meibomian Gland Dysfunction
Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunction
In this study, investigator aim to evaluate the changes of tear-film lipid layer thickness and ocular aberration after treatment of meibomian gland dysfunction.
- Trial name
- NCT02618304
- Testing
- Treatment of Meibomian gland dysfunction
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Yonsei University
Cervicogenic Headache
Specific Neck Rehabilitation for Unilateral Headache and Neck Pain, and Structural and Functional Changes in the Brain
In part 1 of the project clinical effect of specific neck rehabilitation for unilateral headache and neck pain (also termed cervicogenic headache) will be compared with standard primary health care.
- Trial name
- NCT02908984
- Testing
- Specific neck rehabilitation, Standard primary health care
- Where
- Norway
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Cardiac Arrest
Refractory Out-Of-Hospital Cardiac Arrest Treated With Mechanical CPR, Hypothermia, ECMO and Early Reperfusion
Sudden out-of-hospital cardiac arrest (OHCA) is a leading cause of death in Australia. The most common cause of OHCA is a heart attack.
- Trial name
- CHEER (NCT01186614)
- Testing
- Automated CPR, ECMO, Coronary angiography
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Bayside Health
Bronchiolitis
Vitamin D Supplementation for Acute Bronchiolitis
This study was conducted to evaluate the effect of oral vitamin D supplementation on the clinical course of acute bronchiolitis, and to investigate whether vitamin D deficiency among infants who required hospital-based care for…
- Trial name
- NCT03799406
- Testing
- Cholecalciferol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol).
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product…
- Trial name
- NCT01967706
- Testing
- mTHS, mCC, NRT
- Where
- Japan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Aseptic; Osteonecrosis, Hip Osteoarthritis
Radiographic Changes and Clinical Implications of Implantation of Shortened Uncemented Femoral Stems in THA
The hip prosthesis market is constantly growing with the number of prostheses reaching 949,000 in 2019. Along with this, there is also an increase in interest in short stems also called shortened stems.
- Trial name
- THA (NCT05666284)
- Where
- France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Strasbourg, France
Varicocele, Male Infertility
Intratesticular Artery Resistive Index Changes After Varicocelectomy
This study aims to evaluate how blood flow inside the testicles changes after surgery to correct a varicocele, and whether these changes correlate with improvements in semen quality and testosterone levels.
- Conditions
- Varicocele, Male Infertility, Secondary Hypogonadism
- Trial name
- NCT07517952
- Testing
- Microscopic Sub-inguinal Varicocelectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
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